Pingping Shen, Xuewa Jiang, Yi Kuang, Weiwei Wang, Richa Raj, Wei Wang, Yuyuan Zhu, Xiaochun Zhang, Boyang Yu and Jian Zhang
RSC Chem. Biol., 2024,5, 751-762
Abstract
Using the unique triterpenoid probe, we found that the binding interface of HMGB1 was responsible for the recognition of TLR4 located on the “L” shaped B-box with K114 as a crucial hot-spot residue.
Tong Yang, Dandan Liu, Yulei Li, Ying Zhang, Yinhua Zhu, Junzhe Zhang, Chen Wang, Shujie Zhang, Yin Kwan Wong, Piao Luo, Qiuyan Guo, Fei Xia, Tianyu Zhong, Huan Tang and Jigang Wang
Chem. Commun., 2023,59, 8981-8984
Abstract
The global target profiling of Sofalcone identified HMGB1 as the key covalent target for the anti-inflammation activity in intestinal epithelial cells.
Issan Zhang, Dusica Maysinger, Maja Beus, Antonija Mravak, Ziqi Yu, Martina Perić Bakulić, Patrick A. Dion, Guy A. Rouleau, Vlasta Bonačić-Koutecký, Rodolphe Antoine and Željka Sanader Maršić
Nanoscale, 2025,17, 1092-1104
From themed collection:
Celebrating International Women’s day 2025: Women in Nanoscience
Abstract
The gold nanocluster Au25AcCys18 modulates human microglia and neuronal cells at the level of oxidative stress and protein–protein interactions (HMGB1 and TFEB). Complementary computational and biological methods reveal these interactions.
Kateryna Horbatok, Iryna Semchuk, Oleksandr Horbach, Natalia Khranovska, Viktoriia Kosach, Petro Borysko, Serhii Koniev, Anne S. Ulrich, Sergii Afonin and Igor V. Komarov
RSC Med. Chem., 2025,16, 3456-3468
From themed collection:
Highlights from Industry
Abstract
The key markers of immunogenic cell death were detected in mammalian cell cultures upon co-incubation with gramicidin S and its photoswitchable analogues at the sub-membranolytic concentrations, suggesting an immunotherapeutic potential for peptides.
Haizhou Qiu, Kunlin Chen, Yiwen Qiu, Yi Yang, Tao Wang, Li Jiang and Wentao Wang
J. Mater. Chem. B, 2025,13, 15322-15340
Abstract
DOX@MPDA-TPP@HA couples HA–CD44–mediated uptake with TPP-mediated mitochondrial targeting and pH/NIR-triggered release, enabling chemo-photothermal therapy, inducing ICD, and activating antitumor immunity in HCC.