Essential structural motifs for design of Lead against VEGFR-2.
The review describes anti-VEGFR-2 activity of heterocycles including quinazoles, pyrimidines, isatin and azoles considering SAR for a given set of derivatives. Compounds with potent activity were emphasized with description of structural features.
A novel series of quinazoline-based compounds were designed and synthesized as modified analogues to certain known VEGFR-2 inhibitors, as an extension of our work on the design and synthesis of new VEGFR-2 inhibitors.
Design, synthesis and in vitro and in silico studies of novel quinoxaline-based derivatives as antitumor VEGFR-2 inhibitors with apoptotic activities.
Sorafenib-inspired benzofuran hybrids were designed as VEGFR-2 inhibitors; lead 7g showed potent, selective anti-HCC activity, inducing cell cycle arrest and apoptosis, nominating it as a promising HCC-targeted lead.