The highly enantioselective hydrogenation of allylic sulfones catalyzed by Rh-(R,R)-f-spiroPhos for synthesis of chiral β-ester sulfones has been developed for the first time achieving high yields and excellent enantioselectivities (92–99.9% ee).
This review summarizes the recent advances (2016–2023) in the stereoselective metal-catalyzed hydrogenation of cyclic α,β-unsaturated ketones, lactams and lactones since considerable developments were made. Where possible the application of these methodologies in synthesis is outlined.
This review highlights the progress achieved in transition-metal (ruthenium, rhodium, iridium, and nickel) catalyzed asymmetric hydrogenation of unsaturated sulfones including substrate scopes, catalytic mechanisms, and applications.
A highly chemo- and enantioselective hydrogenation of arylidene chromanones/cyclohexanones catalyzed by the Rh-f-spiroPhos complex has been developed, providing chiral chromanones with up to 98% ee and achieving high turnover numbers (TON = 2000).
A new hexadentate 1,4,7-triazacyclononane-based ligand bearing methylene-(2,2,2-trifluoroethyl)phosphinate pendant arms was synthesized and its complexes with selected metal ions were studied.