A new atom-economical method for chlorinative dearomatization of arenols and heteroarenols has been developed. The production of 27 dearomatized compounds in yields ranging from 38 to 98% is reported.
This review summarizes recent advances (last 5 years) in C–H halogenation via directing groups like amides, carboxylic acids, 8-aminoquinoline, N-oxides, and heterocycles, emphasizing regioselective aryl halide synthesis in modern organic chemistry.
The functionalization of the C(sp3)–H bond through an oxidative cross-dehydrogenative coupling strategy represents a challenging transformation in the field of organic chemistry.
In this review, 8-aminoquinoline, 8-hydroxyquinoline, and 1-naphthylamine scaffolds are classified, and the constructions of their selective C–H activation systems are reviewed in terms of photocatalytic and electrocatalytic synthesis.
Halosulfoamidation of [1.1.1]propellane with sodium hypohalites and sulfonamides provides a sustainable way to synthesize C3-halo substituted bicyclo[1.1.1]pentylamine.