This review carefully summarizes the advances achieved in catalytic hydrofunctionalization of ynamides and is categorized by the bond formation type including C−C, C−X, C−O, C−N, C−S, C−P, C−Si, and C−Ge bonds.
Herein, a reagent-free regio- and stereospecific cis-hydrophenoxylation of ynamides with acidic phenols, which meets the demands of modern green chemistry well, has been achieved.
A K2CO3-promoted tandem ring-opening and ring-closing of N-alkynyl-2-oxazolidinones at r.t. has been described, affording 2-oxazolines in 42–99% yields without column chromatography purification.
An efficient copper-catalyzed formal [4 + 1] annulation of N-propargyl ynamides with diketones has been developed, allowing practical and atom-economic synthesis of valuable pyrrole-substituted dioxoles in generally moderate to excellent yields.
A novel synthetic strategy for the construction of AviCys analogues via a highly efficient regio- and stereoselective hydrosulfuration of ynamides was reported.