A direct asymmetric synthesis of α-(3-pyrrolyl)methanamines has been developed for the first time with good yields and excellent enantioselectivity under mild conditions by avoiding protection–deprotection chemistry.
A two-pot process is developed to access pyrrolo[2,3-d]pyridazin-7-one's and pyrrolo[2,3-d]pyrizidines through the pyrrole-2,3-dione as an intermediate compound.
Quantitative pyrrole protection was achieved through a self-driven pathway by the combinational assistance of solvent water and dissociative weak H+.
Synthetic strategies towards pyrroles within chiral frameworks are summarised, focussing on reports published 2010–2023.
Improved syntheses, detailed characterizations and reactions of a series of acene-2,3-dicarbaldehydes including tetracene-2,3-dicarbaldehyde are described.