Recent advances in small-molecule fluorescent probes for simultaneous dual detection of HClO/ClO− and analytes/microenvironment

Yongqing Zhou, Mei Yan, Hosoowi Lee and Juyoung Yoon

Chem. Sci., 2026, 17, 6324
DOI: 10.1039/D5SC08843G

Recent progress towards the development of fluorescent probes for the detection of disease-related enzymes

Lopamudra Mishra and Monalisa Mishra

J. Mater. Chem. B, 2025, 13, 763
DOI: 10.1039/D4TB01960A

A dual-enzyme activated fluorescent probe for precise identification of tumor senescence

Xianzhu Luo, Erzhuo Hu, Fei Deng, Cuiling Zhang and Yuezhong Xian

Chem. Sci., 2025, 16, 6507
DOI: 10.1039/D5SC00103J

A ratiometric fluorescence sensor for special detection of β-galactosidase and screening of its inhibitor in complex mixtures

Jiangyue Ning, Shuangshuang Liu, Yujuan Zhan, Binyu Xiao, Hanbing Yao, Zimo Chen, Jiayi Yan, Yifu Li and Chang Shu

Talanta, 2026, 302, 129425
DOI: 10.1016/j.talanta.2026.129425

Bioorthogonally Activatable Photosensitizer for NIR Fluorescence Imaging-Guided Highly Selective Elimination of Senescent Tumor Cells and Chemotherapy Enhancement

Yun Feng, Zifan Zhu, Shirui Zhao, Xingyu Jiang, Wen Zhang and Zhiai Xu

Bioconjugate Chem., 2025, 36, 1066
DOI: 10.1021/acs.bioconjchem.5c00109

Engineering healthy aging: A review of biomedical platforms for mechanistic intervention in geriatric decline

Yuye Liao, Yuliang Dai, Zijin Tang, Hong Ma, Zhiming Tu, Tao Yuan, Yawei Li and Bing Wang

Materials & Design, 2025, 260, 115142
DOI: 10.1016/j.matdes.2025.115142

Extraction optimization of Phellinus baumii residue polysaccharides and investigation of their anti-aging effects via regulation of Keap1/Nrf2/HO-1 signaling pathway

Huanjun Shi, Yanfei Cui, Xiaoman Wang, Bingyi Li, Le Jia and Jianjun Zhang

Preparative Biochemistry & Biotechnology, 2026, 1
DOI: 10.1080/10826068.2026.2630167

Recent Developments in Small-Molecule Fluorescent Probes for Cellular Senescence

Junyoung Park, Youngjun Lee and Jongmin Park

Chemosensors, 2024, 12, 141
DOI: 10.3390/chemosensors12070141

An NIR Fluorescent Probe for Real-Time Polarity Sensing and Targeted Lipid Droplet Imaging in Aging, Cancer, and Fluorescence-Guided Cancer Surgery

Longjie Du, Xingyue Li, Bingxue Li, Ru Ding, Qisheng Zhang, Yuxin Guo, Quan Zhang, Ying Wang, Juan Chen, Xucong Zhou, Zhaosheng Qian and Jin Zhou

Anal. Chem., 2025, 97, 16896
DOI: 10.1021/acs.analchem.5c02124

Engineering HClO Ratiometric Fluorescent Probe by Inducing Molecular Aggregation to Suppress TICT Formation for Monitoring Drug-Induced Liver Injury

Jia Hao Xie, Hai Yan Xing, Li Meng, Yong Zhao, Qiang Zeng, Qi Xiao, Nian Bing Li, Peng Xue and Hong Qun Luo

Anal. Chem., 2025, 97, 220
DOI: 10.1021/acs.analchem.4c03839

HClO‐Activated Near‐Infrared Chemiluminescent Probes with a Malononitrile Group for In‐Vivo Imaging

Yalei Cao, Juqing Gu, Zhijian Chen, Jucai Gao, Jie Yang, Wenbo Wu, Manman Fang, Qianqian Li, Bin Liu and Zhen Li

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202408941

A Turn-ON Near-Infrared Fluorescent Probe for the Detection of Dipeptidyl Peptidase IV Activity in Liver Cancers

Fei Zhang, Yu Mei, Xuefeng Ding, Zaifeng Li, Peng Zhang and Caifeng Ding

Chinese Journal of Organic Chemistry, 2024, 44, 3417
DOI: 10.6023/cjoc202404028

Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics

Tiejun Feng, Fuda Xie, Leo M.Y. Lee, Zhiqiang Lin, Yifan Tu, Yang Lyu, Peiyao Yu, Jialin Wu, Bonan Chen, Ge Zhang, Gary M.K. Tse, Ka Fai To and Wei Kang

Mol Cancer, 2025, 24
DOI: 10.1186/s12943-025-02419-2

An Activatable Fluorescence/Photoacoustic Bimodal Probe for the Detection of Drug-Induced Liver Senescence

Ying-Hong Yan, Jun-Liang Zhou, Li-Li Ren, Ping-Zhao Liang, Wen Zhang, Tian-Bing Ren, Lin Yuan, Xia Yin and Xiao-Bing Zhang

Chemosensors, 2025, 13, 74
DOI: 10.3390/chemosensors13020074

A β‐galactosidase activated near‐infrared fluorescent probe for tracking cellular senescence in vitro and in vivo

Tian Su, Ruijun Shen, Dengchu Tu, Xiaoyue Han, Xianzhu Luo and Fabiao Yu

Smart Molecules, 2025, 3
DOI: 10.1002/smo.20240062

A dual sensitive fluorescence probe for the simultaneous visualization of hypochlorite and viscosity in living cells and zebrafish

Xin Zhang, Xiaoying He, Yanmei Si, Xuqing Nie, Shenghui Lun, Changqin Wang, Li Lin and Yehao Yan

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 325, 125149
DOI: 10.1016/j.saa.2024.125149

Novel Visual Perspective for Tracking of Larval Development, Aging and Antiaging Drugs Screening by Fluorescent Sensing MsrA

Jiayu Zeng, Ting Yang, Yuan Gao, Yunjia Shen, Songjiao Li, Hongshuai Zhang, Jia Zhou, Dan Cheng and Longwei He

Anal. Chem., 2025, 97, 12060
DOI: 10.1021/acs.analchem.4c07050

Revolutionizing Senescence Detection: Advancements from Traditional Methods to Cutting-Edge Techniques

Ruopeng Xiao, Sinan Hu, Xiaohui Du, Yiwen Wang, Ke Fang, Yibin Zhu, Nanbin Lou, Chunhui Yuan and Jing Yang

Aging and disease, 2024, 0
DOI: 10.14336/AD.202.0565

Molecular crossbreeding-engineered self-calibrating probe with large emission shift for dual near-infrared imaging of therapy-induced senescence

Jin Zhou, Bin Feng, Chengmin Li, Feiyi Chu, Yan Mo, Min Lin, Yingqi Zhao, Jingmei Zhou, Xin Deng, Qiangchao Meng, Jiani Huang, Hong Zhang, Xueping Feng and Wenbin Zeng

Biosensors and Bioelectronics, 2025, 289, 117862
DOI: 10.1016/j.bios.2025.117862

Cancer therapy-related cardiovascular aging: mechanisms, monitoring, and intervention strategies

Xinyue Lin, Zhebin Wu, Yanfang Liu and Xiang Liao

Front. Cardiovasc. Med., 2026, 12
DOI: 10.3389/fcvm.2025.1668623

Advances in small-molecule fluorescent probes for cellular senescence diagnosis and therapy: A review

Xiao Wang, Ziwei Huang, Chunhong Sui, Mengran Xu and Xin Sun

Dyes and Pigments, 2025, 235, 112599
DOI: 10.1016/j.dyepig.2024.112599

A self-immobilizing fluorescent probe for single-cell resolution imaging of senescence-associated β-galactosidase

Jing Zhang, Xu Qu, Xiaojie Li, Jibin Ma, Yuan Guo and Jianjian Zhang

Dyes and Pigments, 2026, 251, 113734
DOI: 10.1016/j.dyepig.2026.113734

Peroxynitrite activated near-infrared fluorescent probe for fluorescence and afterglow imaging of Alzheimer's disease brain

Xuefeng Ding, Yiwei Shi, Zixuan Liu, Chengmei Liu, Qian Zhang, Peng Zhang and Caifeng Ding

Dyes and Pigments, 2026, 245, 113155
DOI: 10.1016/j.dyepig.2025.113155

Reactive Oxygen Species (ROS)–Tyrosinase Cascade-Activated Near-Infrared Fluorescent Probe for the Precise Imaging of Melanoma

Ruidian Lv, Sitong Hang, Yuran Zhao, Weijie Gao, Peng Zhang, Ke Zheng, Qian Zhang and Caifeng Ding

Anal. Chem., 2025, 97, 4241
DOI: 10.1021/acs.analchem.5c00018

Activatable Multiplexed 19F NMR Probes for Dynamic Monitoring of Biomarkers Associated with Cellular Senescence

Jian Wang, Donghui Hong, Jili Li, Linlin Wang, Yuqi Xie, Jun Da and Yanlan Liu

ACS Meas. Sci. Au, 2024, 4, 577
DOI: 10.1021/acsmeasuresciau.4c00045

Engineering a durable BDDE cross-linked collagen filler for skin rejuvenation

Qi Wang, Huiyu Yan, Jingting Zhang, Xinyu Tian and Jianxi Xiao

Biomed. Mater., 2024, 19, 055021
DOI: 10.1088/1748-605X/ad6548

The role and potential therapeutic intervention of cellular senescence in intervertebral disc degeneration

Yunbo Guan, Xuedong Bai, Chao Li, Ziqiang Zhang, Qing He, Lin Chen, Yangli Xie and Zuqiang Wang

Genes & Diseases, 2026, 13, 101871
DOI: 10.1016/j.gendis.2025.101871

A Novel Ratiometric Fluorescent Probe Based on Ortho-Position Oxime Functionalized Perylene Diimide for Supersensitive HClO/ClO– Recognition and Bioimaging in Cells and Zebrafish

Ruida Shi, Chengcheng Sun, Tieshan Zhang, Shiyin Li, Yujing Zuo, Haitao Yu and Yanyu Qi

Anal. Chem., 2025, 97, 16079
DOI: 10.1021/acs.analchem.5c03768

Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review)

Yatsu Lam, Jiaming Gu and Peihao Yin

Oncol Lett, 2025, 30, 1
DOI: 10.3892/ol.2025.15338

Aggregation‐based dual‐target probe for dual‐colour super‐resolution monitoring mitophagy and evaluating drugs regulating mitochondria

Xiu‐Zhi Yang, Hongbao Fang, Shumeng Li, Chengyan Chu, Yunhua Zhang, Ying Yang, Weijiang He, Yuncong Chen and Zijian Guo

Aggregate, 2025, 6
DOI: 10.1002/agt2.641

Exploring the molecular and immune landscape of cellular senescence in lung adenocarcinoma

Kun Ru, Liang Cui, Cong Wu, Xin X. Tan, Wen T. An, Qiang Wu, Yu T. Ma, Yu Hao, Xiao Xiao, Jing Bai, Xiang Liu, Xue F. Xia and Miao Q. Zhao

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1347770