Catalytic Photooxygenation Demonstrates Therapeutic Efficacy in Transthyretin Amyloidosis

Mina Yamane, Hiroki Umeda, Moe Toyobe, Atsushi Iwai, Kuraudo Ishihara, Genki Kudo, Harunobu Mitsunuma, Yukiko Hori, Taisuke Tomita, Mineyuki Mizuguchi, Masamitsu Okada, Mitsuharu Ueda, Yukio Ando, Shigehiro A. Kawashima, Youhei Sohma, Hironori Kaji, Takatsugu Hirokawa, Kunitoshi Yamanaka and Motomu Kanai

J. Am. Chem. Soc., 2025, 147, 28860
DOI: 10.1021/jacs.5c06205

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma and Motomu Kanai

ChemistryEurope, 2026, 4
DOI: 10.1002/ceur.202500192

Dexter Energy Transfer Photocatalytic Microdissection of Amyloid Plaques in Alzheimer’s Disease

Rui Sun, Jintai Deng, Di Shen, Jing Yan, Yanan Huang, Huan Feng, Man Li, Yusong Ge, Xin Zhang and Yu Liu

JACS Au, 2026, 6, 1129
DOI: 10.1021/jacsau.5c01509

Photo‐oxygenation of histidine residue inhibits α‐synuclein aggregation

Reito Nakamura, Ikumi Tomizawa, Atsushi Iwai, Tetsuo Ikeda, Kota Hirayama, Yung Wen Chiu, Takanobu Suzuki, Airi Tarutani, Tatsuo Mano, Atsushi Iwata, Tatsushi Toda, Youhei Sohma, Motomu Kanai, Yukiko Hori and Taisuke Tomita

The FASEB Journal, 2023, 37
DOI: 10.1096/fj.202301533R

Histidine Photooxygenation Chemistry: Mechanistic Evidence and Elucidation

Ryota Matsukawa, Mina Yamane and Motomu Kanai

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300198

Proteolytic therapeutic modalities for amyloidoses: Insights into immunotherapy, PROTAC, and photo-oxygenation

Mai Kuriyama, Chu Fan Wang, Tatsuya Nagase, Youhei Sohma, Motomu Kanai, Yukiko Hori and Taisuke Tomita

Neurotherapeutics, 2025, 22, e00548
DOI: 10.1016/j.neurot.2025.e00548