Extraction, purification, structural characterization, and biological activity of polysaccharides from Schisandra chinensis: A review

Rong Ji, Zhibin Wang and Haixue Kuang

International Journal of Biological Macromolecules, 2024, 271, 132590
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Extraction, Structural Characteristics, and Antioxidant Activity of a Glucose-Dominated Polysaccharide, NJPW, Purified from Nardostachys jatamansi (D.Don) DC. 

Xinyi Yang, Ying Liang, Pu Liu, Lulu Song and Jiayu Gao

ACS Omega, 2025, 10, 30100
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Integrated ultra‐high‐performance liquid chromatography coupled with quadrupole‐orbitrap mass spectrometry‐based components analysis and network pharmacology strategy of Gancao Xiexin Decoction in treating gastric ulcer

Rongjin Wang, Shoufang Tang, Limei Huang, Ziyi Chen, Yuwen Li, Shu Liu, Fengrui Song, Lihui Men and Zhongying Liu

J of Separation Science, 2024, 47
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Elucidating the molecular basis of Salvia miltiorrhiza Salvianolic acids and Tanshinones in treating ischemic stroke: A multidimensional strategy of in vivo Chemomics, targeted network pharmacology, and metabolomics

Rongjin Wang, Jiayue Wang, Yuwen Li, Yu Li, Shoufang Tang, Junpeng Xing, Zhiqiang Liu, Shu Liu and Zhongying Liu

Journal of Chromatography B, 2026, 1275, 124993
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The extraction, purification, structural features, bioactivities, and applications of Schisandra chinensis polysaccharides: A review

Fei Luan, Junbo Zou, Xiaofei Zhang, Jiuseng Zeng, Xi Peng, Ruiyu Li, Yajun Shi and Nan Zeng

International Journal of Biological Macromolecules, 2024, 262, 130030
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Experimental Research Progress and Transformation Strategy Analysis of Dunhuang Medical Prescriptions

Xiaofei DONG, Xiaoyi YANG and Yingcun LI

Chinese Medicine and Culture, 2025, 8, 450
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Along the microbiota–gut–brain axis: Use of plant polysaccharides to improve mental disorders

Jiayu Gao, Ying Liang and Pu Liu

International Journal of Biological Macromolecules, 2024, 265, 130903
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Screening of anti-inflammatory components in composite Houttuynia mixture using comprehensive two-dimensional ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry and network pharmacology

Xinyue Lin, Luxi Zhou, Lingfang Chen, Qiyue Chen, Zhuming Jin, Peixi Zhu and Ni Yang

Microchemical Journal, 2025, 213, 113660
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Different ratios of Schisandra chinensis and Evodia rutaecarpa combination for treating Alzheimer’s disease

Qingyu Cao, Jiaqi Liu, Peiliang Dong and Hua Han

Exp Biol Med (Maywood), 2023, 248, 1877
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Advances in polysaccharides from traditional Chinese medicine for the treatment of central nervous system disorders: A comprehensive review

Fan Song, Zhigang Mei and Wenli Zhang

International Journal of Biological Macromolecules, 2026, 337, 149416
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Schisandrin A alleviates non-alcoholic fatty liver disease by improving liver metabolic disorders and suppressing the GSK3β signaling pathway

Li Zong, Rui Xu, Yunxia Sun, Junjie Qiu, Huihui Tao, Chengyu Shentu, Hongxia Niu, Tengfei Xu and Yuan Zhou

Food Bioscience, 2024, 62, 105245
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Linoleic acid alleviates mood disorders in mice by modulating microglia differentiation and arachidonic acid metabolism

Meishan Lu, Yanjun Liu, Mengxue He, Jiachen Shi, Yanan Wang, Xue Li and Yuanfa Liu

Food Science and Human Wellness, 2026, 15, 9250540
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The comprehensive mechanism underlying Schisandra polysaccharide in AD-like symptoms of Aβ25-35-induced rats based on hippocampal metabolomics and serum lipidomics techniques

Shuo Zhao, Jinpeng Zhang, Yufeng Chen, Xinyuan Cui, Haiqing Liu, Ying Yan, Yuexiang Sun, Yongxiu Qi and Yuanyuan Liu

Journal of Pharmaceutical and Biomedical Analysis, 2023, 236, 115717
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Integrated metabolomics and proteomics revealed mangiferin alleviating oxidative stress and mitochondrial dysfunction of HT22 cells via regulating the abnormal metabolic pathways

Yan Wang, Jinxuan Chai, Sifan Guo, Zhibo Wang, Shiwei Wang, Xiaodan Yu, Xiaowen He, Aihua Zhang and Shi Qiu

Food Bioscience, 2025, 66, 106138
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Mechanisms and structure-activity relationships of polysaccharides in the intervention of Alzheimer's disease: A review

Jun Tang, Muhammad Yousaf, Ya-Ping Wu, Qin-qin Li, Yi-Qian Xu and Dong-Mei Liu

International Journal of Biological Macromolecules, 2024, 254, 127553
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Identification of active ingredients in Naomaitai capsules using high‐resolution mass spectrometry unite molecular network analysis and prediction of their action mechanisms

Shuang Li, Zhiyan Liu, Haiping Zeng, Jinyu Fu, Mo Sun, Chun Bao and Chenning Zhang

Rapid Comm Mass Spectrometry, 2024, 38
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In-depth investigation of the mechanisms of Schisandra chinensis polysaccharide mitigating Alzheimer's disease rat via gut microbiota and feces metabolomics

Jun Fu, Jixun Li, Yuzhen Sun, Shu Liu, Fengrui Song and Zhongying Liu

International Journal of Biological Macromolecules, 2023, 232, 123488
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Review on dietary supplements as an effective improvement of Alzheimer’s disease: focus on structures and mechanisms

Sheng Li, Yinling Wei, Zhenzhen Liang, Lingli Guo, Xiaojiang Hao and Yu Zhang

Food Science and Human Wellness, 2024, 13, 1787
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Crocin Ameliorates Cognitive Impairment and Pathological Changes in Alzheimer's Disease Model Mice by Regulating Gut Microbiota

Zhiyan Zou, Dan Lei, Xilian Wang, Yuan Yin, Hong Li, Xin Di and Xiaoan Li

Food Science & Nutrition, 2025, 13
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Deciphering the Therapeutic Efficacy and Underlying Mechanisms of Dendrobium officinale Polysaccharides in the Intervention of Alzheimer’s Disease Mice: Insights from Metabolomics and Microbiome

Jun Fu, Zhaohan Liang, Zihao Chen, Yiyang Zhou, Fen Xiong, Qian Liang and Hongchang Gao

J. Agric. Food Chem., 2025, 73, 5635
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Combining Retip Retention Time Prediction with High-Resolution Mass Spectrometry: A Systematic Analysis of Schisandra chinensis-Evodia Conducted for the First Time

Jiaqi Xu, Lincheng Bai, Tiantian Wang, Zeyu Yi, Hua Han and Peiliang Dong

Anal. Chem., 2025, 97, 27988
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Mechanism of Dendrobium officinale polysaccharide in alleviating Alzheimer's disease: Insights from metabolomics, lipidomics, and proteomics analysis

Jun Fu, Zhaohan Liang, Zihao Chen, Weiyuan Chen, Yiyang Zhou, Fen Xiong, Lingfei Meng, Qian Liang and Hongchang Gao

International Journal of Biological Macromolecules, 2025, 319, 145531
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Synergistic mechanism of stir-baked curcumae radix with vinegar in dysmenorrhea rats based on UPLC-Q-TOF/MS metabolomics

Jie Wu, Mayijie Cao, Zhuolin Jia, Xiaoli Zhu, Ye Zhou, Yidian Dong, Lingying Yu, Changjiang Hu, Yu Huang and Zhimin Chen

Journal of Pharmaceutical and Biomedical Analysis, 2024, 240, 115944
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Kefiran, a polysaccharide from kefir grain, modulates gut microbiota and hepatic metabolism to mitigate metabolic dysfunction-associated steatotic liver disease

Yuanyuan Cui, Jiajia Zhu, Jun Xi, Changhe Ding and Jun Meng

International Journal of Biological Macromolecules, 2026, 341, 150147
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Preparation of low molecular weight polysaccharides from Tremella fuciformis by ultrasonic-assisted H2O2-Vc method: Structural characteristics, in vivo antioxidant activity and stress resistance

Quancen Lee, Xianjing Han, Mingfeng Zheng, Feng Lv, Bin Liu and Feng Zeng

Ultrasonics Sonochemistry, 2023, 99, 106555
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Untargeted metabolomics and mendelian randomization analysis identify alpha-linolenic acid and linoleic acid as novel biomarkers of perioperative neurocognitive dysfunction

Xinxin Yang, Li Huang, Yanyan Zhang, Kaixin Wang, Shiya Liu, Xiaojin Li, Yuanyuan Ding, Daling Deng, Tianhao Zhang, Wenjing Zhao, Lulin Ma, Yafeng Wang, Shaofang Shu and Xiangdong Chen

Clinical Nutrition, 2024, 43, 2198
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Arachidonic acid in aging: New roles for old players

Chen Qian, Qing Wang, Yusen Qiao, Ze Xu, Linlin Zhang, Haixiang Xiao, Zhixiang Lin, Mingzhou Wu, Wenyu Xia, Huilin Yang, Jiaxiang Bai and Dechun Geng

Journal of Advanced Research, 2025, 70, 79
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Gut microbiota and its metabolites: A potential approach for traditional Chinese medicine-derived non-starch polysaccharides to delay aging and prevent age-related diseases–A review

Qiling Zhang, Yuling Liu, Ruying Tang, Shasha Kong, Dan Lv, Hui Li, Hongjun Yang and Longfei Lin

Carbohydrate Polymer Technologies and Applications, 2024, 8, 100567
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An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Mengzhen Jia, Li Zhou, Yuanyuan Lou, Xiaoqing Yang, Hangyu Zhao, Xinshou Ouyang and Yanjie Huang

Front. Nutr., 2023, 10
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Radix Hedysari Polysaccharides modulate the gut-brain axis and improve cognitive impairment in SAMP8 mice

Sixia Yang, Linshuang Wang, Xiaotong Liang, Tingting Pei, Yi Zeng, Bicen Xie, Yuhua Wang, Min Yang, Dongfeng Wei and Weidong Cheng

International Journal of Biological Macromolecules, 2025, 306, 141715
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Rosa roxburghii Tratt juice ameliorates metabolic disorder in arsenicosis patients based on the analysis of untargeted plasma metabolomics

Luming Yang, Kai Zhu, Wenjuan Wang, Baofei Sun, Peng Luo and Aihua Zhang

Front. Pharmacol., 2025, 16
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Identification of In Vivo Components in Shiduqing Capsule Using High‐Resolution Mass Spectrometry and Network Pharmacology‐Based Analysis of Its Therapeutic Mechanisms Against Eczema

Shuang Li, Zhiyan Liu, Ping Sun, Ayiguzhali Yusun, Mo Sun, Chun Bao and Chenning Zhang

Rapid Comm Mass Spectrometry, 2025, 39
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Urine Metabolites and Bioactive Compounds from Functional Food: Applications of Liquid Chromatography Mass Spectrometry

Eng Shi Ong

Critical Reviews in Analytical Chemistry, 2024, 54, 3196
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Serum and urine metabolomics based on UPLC–QTOF/MS reveal the effect and potential mechanism of “schisandra–evodia” herb pair in the treatment of Alzheimer's disease

Chengguo Pang, Ruijiao Wang, Kemeng Liu, Xu Yuan, Jiating Ni, Qingyu Cao, Yuanjin Chen, Pei Liang Dong and Hua Han

Biomedical Chromatography, 2024, 38
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Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review

Dagmara Wróbel-Biedrawa and Irma Podolak

Molecules, 2024, 29, 866
DOI: 10.3390/molecules29040866

Extraction, purification, structural characterization, and bioactivities of the genus Schisandra polysaccharides: A review

Shujun Chen, Fang Qin, Ying Yang, Yu Zhao, Shuyun Xiao, Wei Li, Toshihiro Akihisa, Pensak Jantrawut, Jingyu Ji and Jie Zhang

International Journal of Biological Macromolecules, 2024, 262, 130257
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