Antibiotic exposure at environmental concentrations under high-fat diet: Impacts on gut microbiota and metabolism

Liang Zhao, Jian Xu, Xiaowei Li, Saiwa Liu, Jingjing Du, Xi Jia, Zhinan Wang, Lirui Ge, Kexin Cui, Yu Ga, Jianzhong Shen and Xi Xia

Environment International, 2025, 202, 109679
DOI: 10.1016/j.envint.2025.109679

Treatment of Insomnia With Traditional Chinese Medicine Presents a Promising Prospect

Boyi Zhang, Qianqian Wang, Yuhang Zhang, Hanyu Wang, Jingyu Kang, Yandi Zhu, Baiyan Wang and Shuying Feng

Phytotherapy Research, 2025, 39, 2724
DOI: 10.1002/ptr.8495

Tumor Microenvironment Targeted by Polysaccharides in Cancer Prevention: Expanding Roles of Gut Microbiota and Metabolites

Shuai Han, Yi Luo, Zuomin Hu, Xinhua Li, Yaping Zhou and Feijun Luo

Molecular Nutrition Food Res, 2025, 69
DOI: 10.1002/mnfr.202400750

Health benefits of medicinal plant natural products via microbiota-mediated different gut axes

Xiang Li, Yufan Liu, Ning Liu, Hanning Wu, Kexin Cong, Linnan Duan, Tianli Chen and Jie Zhang

Pharmacological Research, 2025, 215, 107730
DOI: 10.1016/j.phrs.2025.107730

Antioxidant activity and metabolic profile changes in Poria cocos fermented by breast-milk-derived Limosilactobacillus reuteri HM-R28

Xiaojing Li, Xianping Li, Lu Liu, Junying Zhao, Yue Zhang and Lijun Chen

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1625875

Poria acid inhibit the growth and metastasis of renal cell carcinoma by inhibiting the PI3K/akt/NF-κb signaling pathway

Haotian Yang, Yue Zhao, Bingnan Ren, Yin Wu, Zhihong Qiu, Yan Cheng and Bo Qiu

Heliyon, 2024, 10, e31106
DOI: 10.1016/j.heliyon.2024.e31106

Antioxidant activity of low molecular weight polysaccharides from Tremella fuciformis in Caenorhabditis elegans based on metabolomics analysis

Quancen Lee, Zhixiang Xue, Mingfeng Zheng, Bin Liu and Feng Zeng

Journal of Future Foods, 2025
DOI: 10.1016/j.jfutfo.2025.04.012

Supplementation with stigma maydis polysaccharide attenuates autism‐like behaviors and improves gut function in valproic acid‐induced autism model male rats

Xiaolei Yang, Hongjie Li, Chao Yang and Jie Ge

Intl J of Devlp Neuroscience, 2024, 84, 567
DOI: 10.1002/jdn.10354

Material basis and sleep-improving mechanisms of Lily- Ziziphi Spinosae Semen decoction: systematic evidence from LC-MS, network pharmacology and animal experiments

Fan Jia, Hui Zheng, Yao Xu, Jiani Jiang, Yuhang Wu, Jianxin Liu, Kai He and Yong Yang

Food Science and Human Wellness, 2025, 14, 9250493
DOI: 10.26599/FSHW.2025.9250493

Gut microbiota and serum metabolome reveal the mechanism by which TCM polysaccharides alleviate salpingitis in laying hens challenged by bacteria

Jiali Liu, Pupu Yan, Yana Li, Jie Yu, Yongxi Huang, Ruonan Bai, Man Liu, Ning Wang, Lian Liu, Jun Zhu, Junhao Xiao, Liwei Guo, Guoping Liu, Fuxian Zhang, Xiaolin Yang, Bin He, Jianguo Zeng and Xiaoqin Zeng

Poultry Science, 2024, 103, 103288
DOI: 10.1016/j.psj.2023.103288

Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia

Jingjing Qian, Fengjie Yu, Lin Zheng, Donghui Luo and Mouming Zhao

J. Agric. Food Chem., 2024, 72, 11515
DOI: 10.1021/acs.jafc.4c01074

Natural products: Harnessing the power of gut microbiota for neurological health

Hao Cheng, Juan Liu, Dandan Zhang, Jing Wu, Jinlu Wu, Yaochuan Zhou, Yuzhu Tan, Wuwen Feng and Cheng Peng

Phytomedicine, 2024, 135, 156019
DOI: 10.1016/j.phymed.2024.156019

Chemical structures, extraction and analysis technologies, and bioactivities of edible fungal polysaccharides from Poria cocos: An updated review

Chester Yan Jie Ng, Nicole Poh Yee Lai, Wen Min Ng, Kewin Tien Ho Siah, Ren-You Gan and Linda L.D. Zhong

International Journal of Biological Macromolecules, 2024, 261, 129555
DOI: 10.1016/j.ijbiomac.2024.129555

Sleep deprivation-induced anxiety-like behaviors are associated with alterations in the gut microbiota and metabolites

Nana Zhang, Xuefeng Gao, Donghao Li, Lijuan Xu, Guanzhou Zhou, Mengqi Xu, Lihua Peng, Gang Sun, Fei Pan, Yan Li, Rongrong Ren, Ruolan Huang, Yunsheng Yang, Zikai Wang and Zhenjiang Zech Xu

Microbiol Spectr, 2024, 12
DOI: 10.1128/spectrum.01437-23

Along the microbiota–gut–brain axis: Use of plant polysaccharides to improve mental disorders

Jiayu Gao, Ying Liang and Pu Liu

International Journal of Biological Macromolecules, 2024, 265, 130903
DOI: 10.1016/j.ijbiomac.2024.130903

Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components

Changmei Wu, Jinjin Dou, Xiaoxue Song, Fang Yang, Xuan Liu, Weipeng Song and Xiwu Zhang

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1572007

Summary of drug therapy to treat cognitive impairment-induced obstructive sleep apnea

Daqiang He, Jian Chen, Xiaoxue Du and Linhao Xu

Front. Cell. Neurosci., 2023, 17
DOI: 10.3389/fncel.2023.1222626

Fructus gardeniae ameliorates anxiety-like behaviors induced by sleep deprivation via regulating hippocampal metabolomics and gut microbiota

Dong Liu, Qianfei Wang, Ying Li, Zhenshuang Yuan, Zhiliang Liu, Junli Guo, Xin Li, Weichao Zhang, Yulei Tao and Jianqiang Mei

Front. Cell. Infect. Microbiol., 2023, 13
DOI: 10.3389/fcimb.2023.1167312

Improving precision management of anxiety disorders: a Mendelian randomization study targeting specific gut microbiota and associated metabolites

Ming-Min Xu, Wen-Hui Qiu, Qing-Yu Ma, Zhi-Yun Yu, Wen-Miao Yang, Tian-Nuo Hu, Yu Guo and Xiao-Yin Chen

Front. Microbiol., 2024, 15
DOI: 10.3389/fmicb.2024.1380912

Study on the active ingredients and mechanism of Jiaotai Pill in the treatment of primary insomnia based on network pharmacology and GEO statistics: A review

Limin Pan, Yaolei Wang, Ruiqian Guan and Qingchun Shi

Medicine, 2023, 102, e35253
DOI: 10.1097/MD.0000000000035253

Unveiling the neuroprotective mystery of Kaixinsan: identifying and validating the neuroprotective ingredients under the perspective of gut – brain axis regulation

Jia-Le Ren, Xiao-Li Zhang, Li-Juan Zhao, Gui-Ying Wen, Jia-Fan Liu, Qing-Yu Meng, Zhen Yang, Li-Li Song and Yan-Jun Zhang

Journal of Asian Natural Products Research, 2025, 1
DOI: 10.1080/10286020.2025.2468310

Gut microbiota: A magical multifunctional target regulated by medicine food homology species

Wei-Fang Zuo, Qiwen Pang, Lai-Ping Yao, Yang Zhang, Cheng Peng, Wei Huang and Bo Han

Journal of Advanced Research, 2023, 52, 151
DOI: 10.1016/j.jare.2023.05.011

Erchen decoction alleviates anxiety and depression-like behaviors in high-fat diet-induced obesity mice via the Adipose–Brain axis

Jia-Wei Chen, Mao-Hui Liu, Zhi-Da Yang, Jiu-Shuang Zhu, Jie-Xin Wang, Kun Yang, Jing-Xin Gao, Rong Gan, Ling-Miao Wen, Li Zhang, Ze-Yi Guo, You-Jun Yang, Yan-Ju Gong, Xiu-Wen Xia and Wei-Jun Ding

Journal of Ethnopharmacology, 2025, 352, 120218
DOI: 10.1016/j.jep.2025.120218

A multidimensional perspective on Poria cocos, an ancient fungal traditional Chinese medicine

Juanhong Lei, Dihong Gong, Liting Duan, Ruidan Tang, Wen Gu, Fan Zhang, Yujiao Zhao, Mei Zhang, Xingxin Yang and Jie Yu

Journal of Ethnopharmacology, 2025, 348, 119869
DOI: 10.1016/j.jep.2025.119869

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Humna Liaqat, Amna Parveen and Sun-Yeou Kim

IJMS, 2022, 23, 14968
DOI: 10.3390/ijms232314968

Jiedu Yizhi Formula Improves Cognitive Function by Regulating the Gut Dysbiosis and TLR4/NF-κB Signaling Pathway

Pengqi Zhang, Tianye Wang, Xiaoting Zhu, Lina Feng, Jiale Wang, Yunqiang Li, Xinyue Zhang, Tingting Cui and Mingquan Li

NDT, 2023, Volume 19, 49
DOI: 10.2147/NDT.S393773

The Role of Wolfiporia cocos (F. A. Wolf) Ryvarden and Gilb. Polysaccharides in Regulating the Gut Microbiota and Its Health Benefits

Yong Lai, Xin Lan, Zhicheng Chen, Guanhua Lou, Ying Li, Chang Liu, Jianan Feng, Xi Li and Yu Wang

Molecules, 2025, 30, 1193
DOI: 10.3390/molecules30061193

Three Strains of Lactobacillus Derived from Piglets Alleviated Intestinal Oxidative Stress Induced by Diquat through Extracellular Vesicles

Shengkai Feng, Yihan Liu, Jing Xu, Jinping Fan, Jingjing Li, Zhifeng Wu, Yue Sun and Wen Xiong

Nutrients, 2023, 15, 4198
DOI: 10.3390/nu15194198

Characteristics and properties of a polysaccharide isolated from Wolfiporia cocos as potential dietary supplement for IBS

Xuan Yang, Shun Lu, Yuhan Feng, Chongjiang Cao, Yanliang Zhang and Shujie Cheng

Front. Nutr., 2023, 10
DOI: 10.3389/fnut.2023.1119583

Polysaccharide extracted from Atractylodes macrocephala improves the spleen deficiency constipation in mice by regulating the gut microbiota to affect the 5‐HT synthesis

Lei Chen, Xiangbing Chang, Chuntao Wu, Guofu Luo, Peifeng Zhang and Wei Tian

Neurogastroenterology Motil, 2024, 36
DOI: 10.1111/nmo.14875

Molecular targets and mechanisms of Sijunzi decoction in the treatment of Parkinson’s disease: evidence from network pharmacology, molecular docking, molecular dynamics simulation, and experimental validation

Yang Jiang, Wanfeng Wu, Le Xie, Yue Zhou, Kailin Yang, Dahua Wu, Wenfeng Xu, Rui Fang and Jinwen Ge

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1487474

A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways

Yun-Ju Huang, Hsin-Yu Wu, Wan-Ting Chang, Kuan-Hung Lu, Yu-En Lin, Huai-Syuan Huang, Yun-Sheng Lu and Lee-Yan Sheen

Journal of Traditional and Complementary Medicine, 2025, 15, 414
DOI: 10.1016/j.jtcme.2024.05.002

Synergistic effects of plant polysaccharides and exercise on depression alleviation from the microbiota-gut-brain axis

Youmeng Chen, Xinrong Gong, Yili Chen, Changxi Chen, Songmei Luo and Xin Zhang

Food Bioscience, 2025, 64, 105967
DOI: 10.1016/j.fbio.2025.105967

Structure-activity relationships and mechanisms of natural polysaccharides in modulating neurological disorders via the microbiota-gut-brain axis

Yulin Song, Qingfang Deng, Jiawen Li, Ruhai Chen, Dan Li, Shenglin Wang, Baitong Jing and Xin Zhou

Carbohydrate Polymers, 2025, 367, 123960
DOI: 10.1016/j.carbpol.2025.123960

Progress in the metabolic kinetics and health benefits of functional polysaccharides from plants, animals and microbes: A review

Peng Liu, Liwen Fei, Di Wu, Zhong Zhang, Wanchao Chen, Wen Li and Yan Yang

Carbohydrate Polymer Technologies and Applications, 2024, 7, 100526
DOI: 10.1016/j.carpta.2024.100526

Withaferin A: A potential selective glucocorticoid receptor modulator with anti-inflammatory effect

Yuan Liang, Qiuyan Jiang, Haoyang Zou, Jingqi Zhao, Jie Zhang and Li Ren

Food and Chemical Toxicology, 2023, 179, 113949
DOI: 10.1016/j.fct.2023.113949

Poria cocos Attenuated DSS-Induced Ulcerative Colitis via NF-κB Signaling Pathway and Regulating Gut Microbiota

Xiaojun Song, Wei Wang, Li Liu, Zitong Zhao, Xuebin Shen, Lingyun Zhou, Yuanxiang Zhang, Daiyin Peng and Sihui Nian

Molecules, 2024, 29, 2154
DOI: 10.3390/molecules29092154