Three-component synthesis of arylsulfonyl-substituted indolo[2,1-a]isoquinolinones and benzimidazo-[2,1-a]isoquinolin-6(5H)-ones by SO2insertion and radical cascade cyclization

Jie Zhang, Zixian Yang, Jin-Tao Yu and Changduo Pan

Org. Biomol. Chem., 2022, 20, 3067
DOI: 10.1039/D2OB00409G

Visible-light-promoted organic-dye-catalyzed sulfonylation/cyclization to access indolo[2,1-a]isoquinoline derivatives

Yucai Tang, Jinglin Duan, Biyu Yang, Yupeng He, Changyuan Du and Xiangyang Zhang

Org. Biomol. Chem., 2023, 21, 8152
DOI: 10.1039/D3OB01289A

Metal-free synthesis of carbamoylated dihydroquinolinones via cascade radical annulation of cinnamamides with oxamic acids

Pallav Suman, Kirti Tomar, Chandra Shekhar Nishad and Biplab Banerjee

Org. Biomol. Chem., 2024, 22, 1821
DOI: 10.1039/D3OB01856C

Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry

Archana Vijayakumar, M. Manod, R. Bharath Krishna, Abra Mathew and Chithra Mohan

RSC Med. Chem., 2023, 14, 2509
DOI: 10.1039/D3MD00248A

Metal- and additive-free radical-triggered nitration/cyclization to construct indolo[2,1-α]isoquinoline and benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives usingt-BuONO as nitro reagents

Yucai Tang, Yiting Yang, Qian Zhou, Jinglin Duan, Biyu Yang, Changyuan Du and Yupeng He

Org. Biomol. Chem., 2023, 21, 5254
DOI: 10.1039/D3OB00630A

Visible-light-induced radical cascade sulfonylation/cyclization towards indole-fused pyridine derivatives

Qin Du, Ruohan Pan, Yu Chen and Yucai Tang

RSC Adv., 2025, 15, 216
DOI: 10.1039/D4RA08000A

Synthesis of ester-functionalized indolo[2,1-a]isoquinolinesviairon-catalyzed radical cascade cyclization of 2-aryl-N-acryloyl indoles with carbazates

Yucai Tang, Kaiming Dai, Xingxian Xiang, Yiting Yang and Min Li

Org. Biomol. Chem., 2022, 20, 5704
DOI: 10.1039/D2OB00934J

Pd-catalyzed domino Heck cyclization/cross-coupling of indoles with β-chlorovinyl ketones: synthesis of furan-bearing indolo[2,1-α]isoquinolines with antifungal activity

Yongqi Bai, Xingrui Qi, Hanjing Li, Yihui Ban, Rong Zhao, Yian Wang, Jingli Zhang, Taolei Sun and Guanbin Gao

Org. Biomol. Chem., 2025, 23, 3307
DOI: 10.1039/D5OB00165J

Advances in Synthetic Strategies for Indolo[2,1‐a]isoquinoline Derivatives

Qinghan Li, Lirong Han, Hui Zhou, Jinsong Hou and Xiaohao Shi

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202500035

A Metal-Free TBHP-Triggered Cascade Cyclization of 2-Arylindoles with Alcohols: Synthesis of Hydroxyalkylated Indolo[2,1-a]isoquinoline Derivatives

Min Li, Yucai Tang, Xingxian Xiang, Yiting Yang, Qian Zhou, Kaiming Dai and Feifei Wang

Synlett, 2022, 33, 2038
DOI: 10.1055/a-1952-0009

Recent Advances in the Decarboxylative Acylation/Cyclization of α-Keto Acids

Wu Yechun and Yu Jintao

Chinese Journal of Organic Chemistry, 2022, 42, 3606
DOI: 10.6023/cjoc202205025

Visible-Light-Induced Cascade Azidation/Cyclization of Activated Alkenes to Synthesize Azidated Indolo[2,1-a]isoquinolines

Yucai Tang, Yupeng He, Biyu Yang, Jinglin Duan, Changyuan Du, Jie Jiang, Jiali Li, Ruohan Pan, Yu Chen and Xuewen Liu

Chinese Journal of Organic Chemistry, 2024, 44, 2286
DOI: 10.6023/cjoc202401034

CuCl-Catalyzed Cyanoalkylation/Cyclization to Construct Indolo[2,1-a]isoquinoline Derivatives

Yucai Tang, Qian Zhou, Yiting Yang, Biyu Yang, Jinglin Duan and Xuewen Liu

Russ J Org Chem, 2023, 59, 2176
DOI: 10.1134/S1070428023120151

The Synthesis of 5,6‐dihydrobenzo[4,5]imidazo[2,1‐a]isoquinoline Derivatives via Metal‐Free Radical Cascade Pathway

Youlu Pan, Jinghao Xu, Hongjie Zhang, Rongrong Hao, Zhengrong Shen and Wenhai Huang

Adv Synth Catal, 2022, 364, 3043
DOI: 10.1002/adsc.202200571

Radical Cascade Cyclization of Alkene‐Tethered Compounds: Versatile Approach towards Ring‐Fused Polycyclic Structures

Han Liu, Lei Wang and Jin‐Tao Yu

Asian J Org Chem, 2023, 12
DOI: 10.1002/ajoc.202300101

Photoredox-Catalyst-Free Carboxylation of Unactivated Alkenes in DMSO: Synthesis of Polycyclic Indole Derivatives and Aliphatic Acids

Suvankar Debbarma, Hiroki Hayashi, Yamato Ueno, Wataru Kanna, Kosaku Tanaka and Tsuyoshi Mita

Org. Lett., 2024, 26, 10897
DOI: 10.1021/acs.orglett.4c04051

Copper(I)-Catalyzed Acylation/Cyclization of 2-Aryl-N-acryloyl Indole toward Indolo[2,1-α]isoquinoline Derivatives

Mengna Yang, Yucai Tang, Jie Jiang, Jiali Li, Ruohan Pan, Yu Chen, Jinglin Duan and Songbai Zhang

Chinese Journal of Organic Chemistry, 2025, 45, 307
DOI: 10.6023/cjoc202405027

Photoinduced Difluoromethylation/Cyclization of 2-Aryl Indoles with HCF2SO2Na

Jie Jiang, Jiali Li, Ruohan Pan, Yu Chen, Jiale Liu and Yucai Tang

Chinese Journal of Organic Chemistry, 2025, 45, 1239
DOI: 10.6023/cjoc202409008

Synthesis of Alkylsulfonyl‐Substituted Indolo[2,1‐a]Isoquinolines via Photoredox‐Catalyzed Radical‐Cascade Addition/Sulfonylation/Cyclization with DABCO ⋅ (SO2)2 and Thianthrenium Salts

Xin Yuan, Jie Liu, Long‐Zhou Qin, Xiu Duan, Jian Wang, Meng‐Yu Wu, Jiang‐Kai Qiu and Kai Guo

Adv Synth Catal, 2023, 365, 555
DOI: 10.1002/adsc.202201294

Synthesis of arylacylated oxindoles via visible light‐promoted Smiles rearrangement

Yihuo Liu, Siyu Ding, Mingli Xu, Jinli Xu, Dongping Cheng, Hong Wang and Xiaoliang Xu

ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202202563

Free-Radical-Involved Trifluoromethylthiolation Cyclization of Alkenes To Access SCF3-Substituted Indolo[2,1-a]isoquinolines

Yang Li, Lijun Li, Qinqin Yan, Yingming Ren, Xuan Li, Zhong-Quan Liu and Zejiang Li

Synlett, 2022, 33, 1938
DOI: 10.1055/a-1937-9244

Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones under Mild Conditions

Kaixia Sui, Yuting Leng and Yangjie Wu

ACS Omega, 2023, 8, 7517
DOI: 10.1021/acsomega.2c06689

A rapid access to fused polycyclic indolo[2,1-a]isoquinolins via Pd-catalyzed sequential Heck /C-H activation/amination reaction with diaziridinone

Junhua Li, Yu Fu and Yian Shi

Chinese Chemical Letters, 2025, 111376
DOI: 10.1016/j.cclet.2025.111376