Towards an understanding of the biological activity of naphthylisoquinoline alkaloids: DNA-binding properties of dioncophyllines A, B, and C

Denisa Soost, Gerhard Bringmann and Heiko Ihmels

New J. Chem., 2022, 46, 20292
DOI: 10.1039/D2NJ04081F

Neighboring group-directed asymmetric [2 + 2 + 2] cycloaddition to access C–N axially chiral indoles

Xuan Zhang, Qi Teng, Yanru Ren, Baitong Wei, Chen-Ho Tung and Zhenghu Xu

Org. Chem. Front., 2024, 11, 2857
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Asymmetric rhodium-catalyzed click cycloaddition to access C–N axially chiralN-triazolyl indoles

Li Zhou, Yankun Li, Shunian Li, Zhenwei Shi, Xue Zhang, Chen-Ho Tung and Zhenghu Xu

Chem. Sci., 2023, 14, 5182
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Isolation, biological activity, and synthesis of isoquinoline alkaloids

Xiaorong Yang, Xiaolou Miao, Lixia Dai, Xiao Guo, Janar Jenis, Jiyu Zhang and Xiaofei Shang

Nat. Prod. Rep., 2024, 41, 1652
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Organocatalytic diastereo- and atropo-selective construction of eight-membered bridged (hetero)biaryls via asymmetric intramolecular [3 + 2] cycloaddition

Yue Wang, Yue Huang, Xiaoze Bao, Xingfu Wei, Shiqiang Wei, Jingping Qu and Baomin Wang

Chem. Sci., 2024, 15, 8880
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Naphthylisoindolinone alkaloids: the first ring-contracted naphthylisoquinolines, from the tropical liana Ancistrocladus abbreviatus, with cytotoxic activity

Shaimaa Fayez, Torsten Bruhn, Doris Feineis, Laurent Aké Assi, Prem Prakash Kushwaha, Shashank Kumar and Gerhard Bringmann

RSC Adv., 2022, 12, 28916
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The ballet of nature: the interconvertible isomerisation of natural products

Ze-Jun Xu, Jing-Jing Han, Chun-Yang Zhang and Hong-Xiang Lou

Nat. Prod. Rep., 2025
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Enantioselective Synthesis of Axially Chiral Styrene‐Carboxylic Esters by Rhodium‐Catalyzed Chelation‐Controlled [2+2+2] Cycloaddition

Daisuke Yokose, Yuki Nagashima, Suzuka Kinoshita, Juntaro Nogami and Ken Tanaka

Angewandte Chemie, 2022, 134
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Catalytic Atroposelective Synthesis of Axially Chiral Heterobiaryl Oxime Ethers via the One-Step Dynamic Kinetic Condensation Reaction

Qianqian Xu, Jifan Jia, Haitong Fan, Zhifeng Ma, Yuqing Wu, Yifeng Zhang, Ping Su, Wei Gao, Yuji Wang and Dan Li

Org. Lett., 2024, 26, 2403
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Toyaburgine, a Synthetic N-Biphenyl-Dihydroisoquinoline Inspired by Related N,C-Coupled Naphthylisoquinoline Alkaloids, with High In Vivo Efficacy in Preclinical Pancreatic Cancer Models

Suresh Awale, Juthamart Maneenet, Nguyen Duy Phan, Hung Hong Nguyen, Tsutomu Fujii, Heiko Ihmels, Denisa Soost, Nasir Tajuddeen, Doris Feineis and Gerhard Bringmann

ACS Chem. Biol., 2025, 20, 917
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Enantioselective Synthesis of Axially Chiral Styrene‐Carboxylic Esters by Rhodium‐Catalyzed Chelation‐Controlled [2+2+2] Cycloaddition

Daisuke Yokose, Yuki Nagashima, Suzuka Kinoshita, Juntaro Nogami and Ken Tanaka

Angew Chem Int Ed, 2022, 61
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Phosphine-Catalyzed Stereospecific and Enantioselective Desymmetrizative [3+2] Cycloaddition of MBH Carbonates and N-(2-tert-Butylphenyl)maleimides

Jie Hou, Wei Hao, Ying Chen, Zhen Wang and Weijun Yao

J. Org. Chem., 2024, 89, 9068
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Bayesian optimization-driven parallel-screening of multiple parameters for the flow synthesis of biaryl compounds

Masaru Kondo, H. D. P. Wathsala, Mohamed S. H. Salem, Kazunori Ishikawa, Satoshi Hara, Takayuki Takaai, Takashi Washio, Hiroaki Sasai and Shinobu Takizawa

Commun Chem, 2022, 5
DOI: 10.1038/s42004-022-00764-7

Ancistrobrevinium A, the first N -methylated, cationic naphthylisoquinoline alkaloid, from the tropical liana Ancistrocladus abbreviatus (Ancistrocladaceae)

Nasir Tajuddeen, Shaimaa Fayez, Prem Prakash Kushwaha, Doris Feineis, Laurent Aké Assi, Shashank Kumar and Gerhard Bringmann

Natural Product Research, 2024, 38, 2614
DOI: 10.1080/14786419.2023.2194648

Atropisomers with Axial and Point Chirality: Synthesis and Applications

Xing-Feng Bai, Yu-Ming Cui, Jian Cao and Li-Wen Xu

Acc. Chem. Res., 2022, 55, 2545
DOI: 10.1021/acs.accounts.2c00417

Cytotoxicity of dioncophylline A and related naphthylisoquinolines in leukemia cells, mediated by NF-κB inhibition, angiogenesis suppression, G2/M cell cycle arrest, and autophagy induction

Rümeysa Yücer, Shaimaa Fayez, Doris Feineis, Sabine M. Klauck, Letian Shan, Gerhard Bringmann, Thomas Efferth and Mona Dawood

Phytomedicine, 2024, 126, 155267
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Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities

Jun Li, Nasir Tajuddeen, Doris Feineis, Virima Mudogo, Marcel Kaiser, Ean-Jeong Seo, Thomas Efferth and Gerhard Bringmann

Bioorganic & Medicinal Chemistry Letters, 2023, 86, 129258
DOI: 10.1016/j.bmcl.2023.129258

The antidiabetic properties of lignans: a comprehensive review

Murtala Bindawa Isah, Nasir Tajuddeen, Anas Yusuf, Aminu Mohammed, Mohammed Auwal Ibrahim, Matthias Melzig and Xiaoying Zhang

Phytomedicine, 2025, 141, 156717
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An updated review of isoquinoline alkaloids: Biological activity and mode of action, structural modifications, and agricultural applications

Xiaorong Yang, Tong Bu, Yuchao Ma, Xiaoyan Yu, Zile Gong, Jing Wang, Xueyan Liu, Janar Jenis, Hongwei Hu, Xiaolou Miao and Xiaofei Shang

Industrial Crops and Products, 2025, 234, 121591
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New Axially Chiral Molecular Scaffolds with Antibacterial Activities against Xanthomonas oryzae pv. oryzae for Protection of Rice

Yanlin Chen, Tingting Li, Zhichao Jin and Yonggui Robin Chi

J. Agric. Food Chem., 2022, 70, 6050
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Desymmetrization of Prochiral N-Pyrazolyl Maleimides via Organocatalyzed Asymmetric Michael Addition with Pyrazolones: Construction of Tri-N-Heterocyclic Scaffolds Bearing Both Central and Axial Chirality

Jianqi Geng, Xingfu Wei, Biru He, Yuting Hao, Jingping Qu and Baomin Wang

Molecules, 2023, 28, 4279
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Droserone and dioncoquinone B, and related naphthoquinones as potent antiausterity agents against human PANC-1 pancreatic cancer cells

Juthamart Maneenet, Nasir Tajuddeen, Hung Hong Nguyen, Rintaro Fujii, Blaise Kimbadi Lombe, Doris Feineis, Suresh Awale and Gerhard Bringmann

Results in Chemistry, 2024, 7, 101352
DOI: 10.1016/j.rechem.2024.101352

Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate

Daniela Brünnert, Raina Seupel, Pankaj Goyal, Matthias Bach, Heike Schraud, Stefanie Kirner, Eva Köster, Doris Feineis, Ralf C. Bargou, Andreas Schlosser, Gerhard Bringmann and Manik Chatterjee

Pharmaceuticals, 2023, 16, 1181
DOI: 10.3390/ph16081181

Enantioconvergent synthesis of axially chiral amides enabled by Pd-catalyzed dynamic kinetic asymmetric aminocarbonylation

Lei Su, Shen Gao and Jiawang Liu

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-51717-8

Korupensamine A, but not its atropisomer, korupensamine B, inhibits SARS-CoV-2 in vitro by targeting its main protease (Mpro)

Ahmed M. Sayed, Alyaa Hatem Ibrahim, Nasir Tajuddeen, Jürgen Seibel, Jochen Bodem, Nina Geiger, Kathrin Striffler, Gerhard Bringmann and Usama Ramadan Abdelmohsen

European Journal of Medicinal Chemistry, 2023, 251, 115226
DOI: 10.1016/j.ejmech.2023.115226

Atroposelective Amination of Indoles via Chiral Center Induced Chiral Axis Formation

Yong Wang, Jingxue Yan, Yiqing Jiang, Zexuan Wei, Zhenlin Tu, Chao Dong, Tao Lu, Yadong Chen and Jie Feng

Molecules, 2022, 27, 9008
DOI: 10.3390/molecules27249008

Naphthylisoquinoline alkaloids: novel agents against the causative pathogens of eumycetoma and actinomycetoma— en route to broad-spectrum antimycetomal drugs

Sami Ahmed Khalid, Shereen Abd Algaffar, Nasir Tajuddeen, Blaise Kimbadi Lombe, Gerhard Bringmann and Audrey Odom John

Antimicrob Agents Chemother, 2024, 68
DOI: 10.1128/aac.01612-23

Unified Photoredox-Catalyzed Aerobic Oxidative Dynamic Kinetic Asymmetric Transformation for C–N Atropoisomers Mediated by Chiral Organophosphites

Pinku Saikia, M. Aarthika, Ayantika Bhattacharjya, Susmita Maity, Priyam Bajpai, Asish Bera, Arindam Saha, Rajesh G. Gonnade, Kumar Vanka and Pradip Maity

Org. Lett., 2025, 27, 8171
DOI: 10.1021/acs.orglett.5c02273

Organocatalytic Asymmetric Synthesis of C−N Atropisomers with Pyrrole, Oxindole and Succinimide Scaffold

Subhankar Biswas, Subham Kundu and Subhas Chandra Pan

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202401132

Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands

Pilar López‐Ram‐de‐Víu, José A. Gálvez and María D. Díaz‐de‐Villegas

Chirality, 2022, 34, 1140
DOI: 10.1002/chir.23475

Enantioselective Synthesis of Atropisomers via Vinylidene ortho-Quinone Methides (VQMs)

Wenling Qin, Yidong Liu and Hailong Yan

Acc. Chem. Res., 2022, 55, 2780
DOI: 10.1021/acs.accounts.2c00486

DNA G-Quadruplexes as Targets for Natural Product Drug Discovery

Kai-Bo Wang, Yingying Wang, Jonathan Dickerhoff and Danzhou Yang

Engineering, 2024, 38, 39
DOI: 10.1016/j.eng.2024.03.015

Catalytic Generation of Remote C–N Axial Chirality through Atroposelectivede novoArene Construction

Subhajit Mondal and Santanu Mukherjee

Org. Lett., 2022, 24, 8300
DOI: 10.1021/acs.orglett.2c03272

The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids

Nasir Tajuddeen, Doris Feineis, Heiko Ihmels and Gerhard Bringmann

Acc. Chem. Res., 2022, 55, 2370
DOI: 10.1021/acs.accounts.2c00432

Dioncophyllidine E: The first configurationally semi-stable, 7,3′-coupled naphthyldihydroisoquinoline alkaloid, from Ancistrocladus abbreviatus, with antiausterity activity against PANC-1 human pancreatic cancer cells

Shaimaa Fayez, Alessia Cacciatore, Juthamart Maneenet, Hung Hong Nguyen, Nasir Tajuddeen, Doris Feineis, Laurent Aké Assi, Suresh Awale and Gerhard Bringmann

Bioorganic & Medicinal Chemistry Letters, 2023, 86, 129234
DOI: 10.1016/j.bmcl.2023.129234