A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in Metabolic Syndrome: Mechanisms and Opportunities

Xiaoxuan Jing, Jingxuan Zhou, Nanhai Zhang, Liang Zhao, Shiran Wang, Liebing Zhang and Feng Zhou

Foods, 2022, 11, 3941
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Evaluation of storage stability and safety of hypoglycemic Pueraria-Ophiopogon tea

Xin Li, Shuxuan Wang, Mei Chen, Yi Xi, Yuanyuan Shan and Xin Lü

Journal of Stored Products Research, 2023, 102, 102124
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Puerarin alleviates acrolein‐induced atherosclerosis by activating the MYH9‐mediated SIRT1/Nrf2 cascade to inhibit the activation of inflammasome

XiaoNing Li, YeTing Li, HuiHui Jiao, AiTing Wang, Man Zheng, ChunYan Xiang and FengLei Zhang

Biotech and App Biochem, 2024, 71, 1129
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Pueraria Radix and Its Major Constituents Against Metabolic Diseases: Pharmacological Mechanisms and Potential Applications

Yicheng Lei, Ruiyuan Zhang, Yan Li, Huiwen Pang, Qiang Fu, Chen Chen and Fang Liu

Phytotherapy Research, 2025
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Component changes of mulberry leaf tea processed with honey and its application to in vitro and in vivo models of diabetes

Huixin Bai, Wei Jiang, Xufang Wang, Na Hu, Linna Liu, Xi Li, Yanhua Xie and Siwang Wang

Food Additives & Contaminants: Part A, 2021, 38, 1840
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Puerarin Attenuates Podocyte Damage in Mice With Diabetic Kidney Disease by Modulating the AMPK/Nrf2 Pathway

Song Xue, Wei Fan, Qingping Li, Hong Huang, Yibo Tang, Min Wu and Kei Nakajima

International Journal of Endocrinology, 2025, 2025
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Corn peptides ameliorate nonalcoholic fatty liver disease by suppressing endoplasmic reticulum stress via the AMPKα/Sirt1 pathway in vivo and in vitro

Zhicui Yao, Shiming Song, Xiaoling Li, Wentao Wang, Peng Ren, Haiyue Wang, Ying Xie and Zengning Li

Journal of Functional Foods, 2022, 93, 105063
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Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression

Xiaoling Zeng, Baohui Chen, Luping Wang, Yingxiao Sun, Zhao Jin, Xuanyong Liu, Liping Ouyang and Yun Liao

Bioactive Materials, 2023, 19, 653
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Puerarin protects against acetaminophen‐induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway

Wanhai Zhou, Heng He, Qin Wei, Litao Che, Xin Zhao, Wenwen Liu, Yue Yan, Lianqing Hu, Yonghua Du, Zhongqiong Yin, Yongkang Shuai, Li Yang and Ruizhang Feng

Food Science & Nutrition, 2023, 11, 6604
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The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Xu-Ting Hao, Rui Peng, Miao Guan, Huan-Jie Zhang, Yuhan Guo, Nashwa M. Shalapy, Xu-Qiang Liu and Chang-Yang Ma

Food & Medicine Homology, 2024, 1, 9420003
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Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes

Si-hui Li, Yan-fei Li, Di Wu, Yu Xu, Hui-jia Yan and Jiang-Ning Hu

Drug Deliv. and Transl. Res., 2024, 14, 757
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Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Yaobin Pang, Shi Wu, Yingjie He, Qing Nian, Jing Lei, Yejing Yao, Jing Guo and Jinhao Zeng

Front. Pharmacol., 2021, 12
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Jinlida Granules Reduce Obesity in db/db Mice by Activating Beige Adipocytes

Hong-ru Zhou, Tong-xing Wang, Yuan-yuan Hao, Yun-long Hou, Cong Wei, Bing Yao, Xuan Wu, Dan Huang, Hui Zhang, Yi-ling Wu and Chunpeng Wan

BioMed Research International, 2022, 2022
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Traditional Chinese Medicine and Ferroptosis in Intracerebral Hemorrhage: A Potential Therapeutic Approach

Hanying Xu, Jing Lu, Xiaolei Tang, Pengfei Li, Lei Wu, Jian Wang, Ying Zhang and Dongmei Zhang

DDDT, 2025, Volume 19, 4789
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Protective effects of puerarin on metabolic diseases: Emphasis on the therapeutical effects and the underlying molecular mechanisms

Qiang Wan, Sang Luo, Qiwen Lu, Chengyan Guan, Hao Zhang and Zhiyan Deng

Biomedicine & Pharmacotherapy, 2024, 179, 117319
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Chinese herbal medicine and active ingredients for diabetic cardiomyopathy: molecular mechanisms regulating endoplasmic reticulum stress

Lianjun Ao, Zhengtao Chen, Jiacheng Yin, Yulin Leng, Yue Luo, Xiaoxu Fu, Hanyu Liu, Xiaoke Liu, Hong Gao and Chunguang Xie

Front. Pharmacol., 2023, 14
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Flavonoids in natural products for the therapy of liver diseases: progress and future opportunities

Yanmei Liao, Fei Lv, Tianwen Quan, Chuan Wang and Jike Li

Front. Pharmacol., 2024, 15
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PHYSICOCHEMICAL CHARACTERISTICS, ANTIOXIDANT PROPERTIES AND THE EFFECT OF THE NEWLY SYNTHESIZED PEPTIDE ON LIPID DEPOSITION IN CELLS

Sergey L. Tikhonov and Natalya V. Tikhonova

IKBFU's Vestnik. Series: Natural and Medical Sciences, 2025, 71
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Natural Compounds Exert Anti‐Obesity Effects by Regulating Cytokines

Yu Zhang, Guize Feng, Weidong Zhang and Xia Liu

Phytotherapy Research, 2025, 39, 2824
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Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations

Lokeshvar Ravikumar, Ramaiyan Velmurugan, J Sam Helinto, S Yokesh, B Divya, Harshitha GS, Harish Kanna S and Mahalakshmi Devaraji

Pharmacological Research - Modern Chinese Medicine, 2025, 14, 100594
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Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high‐fat diet‐induced mice to alleviate obesity

Baoming Tian, Yizhu Pan, Xue Zhou, Yuezhi Jiang, Xiangchun Zhang, Xudong Luo and Kai Yang

J Sci Food Agric, 2024, 104, 5882
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Ligature induced periodontitis in rats causes gut dysbiosis leading to hepatic injury through SCD1/AMPK signalling pathway

Tian Xing, Yajing Liu, Huixin Cheng, Miaomiao Bai, Jingning Chen, Huafeng Ji, Maozhang He and Keyang Chen

Life Sciences, 2022, 288, 120162
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Targeting PI3K/AKT signaling pathway in obesity

Martina S. Savova, Liliya V. Mihaylova, Daniel Tews, Martin Wabitsch and Milen I. Georgiev

Biomedicine & Pharmacotherapy, 2023, 159, 114244
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Effects of puerarin on chronic inflammation: Focus on the heart, brain, and arteries

Li Zhang, Lisheng Liu and Mingyi Wang

Aging Medicine, 2021, 4, 317
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Puerarin alleviates atherosclerosis via the inhibition ofPrevotella copriand its trimethylamine production

Gut, 2024, 73, 1934
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Exploring the mechanisms of Chaige Kangyi Recipe in treating recurrent pregnancy loss with insulin resistance

Jianlan Wu, Yunyan Pan, Yingyu Lu, Jing Qian, Jiaying Zhang, Yuanyuan Xue, Chenxi Xiao, Yuhan Qiu, Mengxin Xie and Shuping Li

Sci Rep, 2025, 15
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Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling

Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao and Luan Shu

Nutritional Neuroscience, 2023, 26, 997
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Effect of natural polyphenols in Chinese herbal medicine on obesity and diabetes: Interactions among gut microbiota, metabolism, and immunity

Keyu Chen, Zezheng Gao, Qiyou Ding, Cheng Tang, Haiyu Zhang, Tiangang Zhai, Weinan Xie, Zishan Jin, Linhua Zhao and Wenke Liu

Front. Nutr., 2022, 9
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Lipid-Lowering Effects of a Novel Polysaccharide Obtained from Fuzhuan Brick Tea In Vitro

Wenjuan Yang, Shirui Cheng, Meng Liu, Nan Li, Jing Wang, Wenbo Yao, Fuxin Chen, Jianwu Xie and Pin Gong

Foods, 2023, 12, 3428
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Puerarin ameliorates nonalcoholic fatty liver in rats by regulating hepatic lipid accumulation, oxidative stress, and inflammation

Jingxuan Zhou, Nanhai Zhang, Adil Aldhahrani, Mohamed Mohamed Soliman, Liebing Zhang and Feng Zhou

Front. Immunol., 2022, 13
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Kudzu isoflavone C‐glycosides: Analysis, biological activities, and metabolism

Jeevan K. Prasain, Stephen Barnes and J. Michael Wyss

Food Frontiers, 2021, 2, 383
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Reduction of obesity and hepatic adiposity in high-fat diet-induced rats by besunyen slimming tea

Chingwen Yu, Xiaoning Wan, Dan Li and Xiaomei Guo

Heliyon, 2023, 9, e17383
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Mechanistic studies on the alleviation of lipid accumulation and oxidative stress by Majia pomelo seed oil

Yidan Zhang, Zuzhen Dai, Shaomin Pu, Taotao Dai, Xixiang Shuai, Yihui Wang, Lizhen Deng, Risi Wang, Ruihong Liang, Ti Li and Jun Chen

Food Bioscience, 2024, 62, 105322
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Antioxidant, Hypoglycemic, and Hypolipidemic Effects of Puerarin In Vivo

Hong Ruan, Wanqing Li, Huien Chang, Manlin Wen, Shouchun Luo, Fangshuai Song, Li Ye, Jie Mei, Xiqiang Zhu, Xiaopeng Liu and Ning Jiang

Food Science & Nutrition, 2025, 13
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Pueraria lobata radix (Ge Gen)-containing traditional Chinese medicine prescriptions for the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis

Haoyu Wang, Huilin Liu, Xiangmin Deng, Ping Luo, Yaqi Tian, Rui Zhang, Gaochuan Zhang, Xunxun Yuan and Xu Zhou

European Journal of Integrative Medicine, 2024, 71, 102405
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Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Ying Hu, Xingjuan Chen, Mu Hu, Dongwei Zhang, Shuo Yuan, Ping Li and Ling Feng

Chin Med, 2022, 17
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Chrysin improves diabetic nephropathy by regulating the AMPK ‐mediated lipid metabolism in HFD / STZ ‐induced DN mice

Yingjun Zhou, Heng Tao, Nuo Xu, Shichun Zhou, Yuke Peng, Jianxiang Zhu, Shaowei Liu and Yaning Chang

Journal of Food Biochemistry, 2022, 46
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Metabolomic analysis of the Puerarin hypoglycemic activity via AMPK-mTOR and PPARγ-NF-κB signaling pathways

Pin Gong, Jiating Wang, Shuang Wang, Wenjuan Yang, Wenbo Yao, Nan Li, Jing Wang, Yanni Zhao, Fuxin Chen, Jianwu Xie, Ting Zhou and Yuxi Guo

Phytomedicine, 2024, 130, 155546
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Exploring the mechanism of Pueraria lobata (Willd.) Ohwi in the regulation of obesity

Jingxin Mao, Maolin Li, Xiaodong Wang, Binbin Wang, Peng Luo, Guoze Wang and Xiulan Guo

Journal of Ethnopharmacology, 2024, 335, 118703
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Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells

Haoran Chen, Xiaofen Qi, Kaifang Guan, Rongchun Wang, Qiming Li and Ying Ma

Journal of Dairy Science, 2023, 106, 2271
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Puerarin: a hepatoprotective drug from bench to bedside

Yi-Xiang He, Meng-Nan Liu, Hao Wu, Qi Lan, Hao Liu, Maryam Mazhar, Jin-Yi Xue, Xin Zhou, Hui Chen and Zhi Li

Chin Med, 2024, 19
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Puerarin as a multi-targeted modulator of lipid metabolism: molecular mechanisms, therapeutic potential and prospects for nutritional translation

Shu Ou, Qingzhi Liang, Yulin Leng, Ting Luo, Xin Xu, Hongyan Xie, Hong Gao, Jun Li and Chunguang Xie

Front. Nutr., 2025, 12
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The mechanisms of hydroxy-α-sanshool from Zanthoxyum bungeanum maxim activates AMPK-HIF1-PKM2 pathway to fix the obesity

Tingyuan Ren, Yuping Zhu, Fangyan Xu, Mintao Lu, Likang Qin and Degang Zhao

Journal of Functional Foods, 2023, 107, 105599
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Dietary Puerarin Enhances Growth, Immune Function, Antioxidant Capacity, and Disease Resistance in Farmed Largemouth Bass, Micropterus salmoides

Yi Huang, Wenjing Ma, Disen Zhang, Xi Chen, Zhiqiu Huang and Yuhang Hong

Fishes, 2025, 10, 197
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Prophylactic role of Premna herbacea, a dietary leafy vegetable in managing hepatic steatosis via regulating AMPK/SREBP1/ACC/HMGCR signaling pathway

Simanta Bharadwaj, Shalini Gurumayum Devi, Pranamika Sarma, Barsha Deka, Sagar Ramrao Barge, Bhaswati Kashyap, Yunus Sheikh, Prasenjit Manna, Jagat C. Borah and Narayan Chandra Talukdar

Food Bioscience, 2022, 48, 101720
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Flavonoids and Other Polyphenols: Bioactive Molecules from Traditional Medicine Recipes/Medicinal Plants and Their Potential for Phytopharmaceutical and Medical Application

Aekkhaluck Intharuksa, Sompop Kuljarusnont, Yohei Sasaki and Duangjai Tungmunnithum

Molecules, 2024, 29, 5760
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Protective effects and mechanism of puerarin targeting PI3K/Akt signal pathway on neurological diseases

Qian Wang, Zi-Nuo Shen, Shu-Jing Zhang, Yan Sun, Feng-Jie Zheng and Yu-Hang Li

Front. Pharmacol., 2022, 13
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Danlou Recipe promotes cholesterol efflux in macrophages RAW264.7 and reverses cholesterol transport in mice with hyperlipidemia induced by P407

Wenrun Han, Dandan Zhang, Peng Zhang, Qianqian Tao, Xiaoli Du, Chunquan Yu, Pengzhi Dong and Yan Zhu

BMC Complement Med Ther, 2023, 23
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Gut microbiota modulation by Traditional Chinese Medicine: a translational strategy for metabolic dysfunction-associated steatotic liver disease

Ting Zhou, Ziwen Jin, Rilei Jiang and Weiwei Li

Front. Pharmacol., 2025, 16
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Qiyu Granules ameliorate insulin resistance via modulating PI3K/AKT/FoxO1 pathway and AMPK/PPARγ pathway in diabetic KKAy mice

Xiaoxu FAN, Jiaqi LIU, Jian HUA, Zhen WANG, Yiwei SHEN, Danyue SHAO, Zhenhui JIN and Jingxia WANG

Chinese Journal of Analytical Chemistry, 2025, 53, 100489
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Natural compounds as obesity pharmacotherapies

Xin‐Yuan Zhao, Ji‐Qiu Wang, G. Gregory Neely, Yan‐Chuan Shi and Qiao‐Ping Wang

Phytotherapy Research, 2024, 38, 797
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Effects of puerarin on growth, liver immunity and antioxidant capacity of yellowfin seabream (Acanthopagrus latus) under oxidized fish oil stress

Lumin Kong, Jianrong Ma, Sishun Zhou, Zhangfan Huang, Xiujuan Wang, Fuqiang Quan, Xi Zhao, Zhenyu Yi, Hao Lin, Longhui Liu, Wanting Luo, Yunting Zhao and Zhongbao Li

Aquaculture Reports, 2024, 37, 102212
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