From the journal:

Chemical Communications

Enantioselective gold(i)-catalysed alkyne hydroarylations for inherently chiral calix[4]arenes

Mehri Goudarzi,a   Anuruddha Alagiyawanna,b   Andrea Serafino,b   Silvia Rizzato, ORCID logo c   Francesco Bertocchi,b   Francesca Terenziani, ORCID logo b   Stefano Santoro, ORCID logo d   Wenling Qin, ORCID logo e   Gianpiero Cera ORCID logo *b  and  Valentina Pirovano ORCID logo *a  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano, Via G. Venezian 21, Milano, Italy
E-mail: valentina.pirovano@unimi.it

b Dipartimento di Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, Parco Area delle Scienze 17/A, I-43124 Parma, Italy
E-mail: gianpiero.cera@unipr.it

c Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, Milano, Italy

d Dipartimento di Chimica, Biologia e Biotecnologie, Via Elce di Sotto, 8, 06123 Perugia, Italy

e Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing, P. R. China

Abstract

We report enantioselective gold(I)-catalysed hydroarylation of alkynes to access inherently chiral calix[4]arenes. This method delivered a family of macrocycles, embedded with phenanthrene motifs, with good yields and enantioselectivities. Investigations of the photophysical and chiroptical properties revealed interesting fluorescence features, suggesting potential applications in materials science and devices.

Graphical abstract: Enantioselective gold(i)-catalysed alkyne hydroarylations for inherently chiral calix[4]arenes

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Article information

DOI
https://doi.org/10.1039/D5CC04405G
Article type
Communication
Submitted
01 Aug 2025
Accepted
14 Sep 2025
First published
15 Sep 2025
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2025, Advance Article

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Enantioselective gold(I)-catalysed alkyne hydroarylations for inherently chiral calix[4]arenes

M. Goudarzi, A. Alagiyawanna, A. Serafino, S. Rizzato, F. Bertocchi, F. Terenziani, S. Santoro, W. Qin, G. Cera and V. Pirovano, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC04405G

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