Issue 32, 2024

Overview of the chemistry and biological activities of natural atisine-type diterpenoid alkaloids

Abstract

Atisine-type C20-diterpenoid alkaloids (DAs) are a very important class of diterpenoid alkaloids, which play an important role in the biosynthesis of DAs. To date, 87 atisine-type DAs and 11 bis-DAs containing an atisine unit have been reported from five genera in two families. The genus Spiraea in Rosaceae family could be regarded as the richest resource for atisine-type DAs, followed by the genera Delphinium and Aconitum in the Ranunculaceae family. Among the reported atisine-type DAs, several possess unprecedented skeletons. Natural atisine-type DAs have a wide range of biological activities, including antitumor, antiplatelet aggregation, biological control, and anti-inflammatory, analgesic, antiarrhythmic, and cholinesterase inhibitory effects, which are closely related to their structures. In particular, the antiparasitic effect of atisine-type DAs is more prominent than that of other types of DAs, which highlights their potential in antiparasite drug discovery. In summary, the high chemical and biological diversity of atisine-type DAs indicates their great potential as a vast resource for drug discovery.

Graphical abstract: Overview of the chemistry and biological activities of natural atisine-type diterpenoid alkaloids

Supplementary files

Article information

Article type
Review Article
Submitted
05 maj 2024
Accepted
15 jul 2024
First published
22 jul 2024
This article is Open Access
Creative Commons BY license

RSC Adv., 2024,14, 22882-22893

Overview of the chemistry and biological activities of natural atisine-type diterpenoid alkaloids

J. Zheng, H. Jiang, Y. Yan and T. Yin, RSC Adv., 2024, 14, 22882 DOI: 10.1039/D4RA03305A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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