Issue 31, 2024

High-load nanoparticles with a chemotherapeutic SN-38/FdUMP drug cocktail

Abstract

[Gd(OH)]2+[(SN-38)0.5(FdUMP)0.5]2− inorganic–organic hybrid nanoparticles (IOH-NPs) with a chemotherapeutic cocktail of ethyl-10-hydroxycamptothecin (SN-38, active form of irinotecan) and 5-fluoro-2′-deoxyuridine-5′-phosphate (FdUMP, active form of 5′-fluoruracil), 40 nm in size, are prepared in water. The IOH-NPs contain a total drug load of 63 wt% with 33 wt% of SN-38 and 30 wt% of FdUMP. Cell-based assays show efficient cellular uptake and promising anti-tumour activity on two pancreatic cancer cell lines of murine origin (KPC, Panc02). Beside the high-load drug cocktail, especially the option to use SN-38, which – although 100- to 1000-times more potent than irinotecan – is usually unsuitable for systemic administration due to poor solubility, low stability, and high toxicity upon non-selective delivery. The [Gd(OH)]2+[(SN-38)0.5(FdUMP)0.5]2− IOH-NPs are a new concept to deliver a drug cocktail with SN-38 and FdUMP directly to the tumour, shielded in a nanoparticle, to reduce side effects.

Graphical abstract: High-load nanoparticles with a chemotherapeutic SN-38/FdUMP drug cocktail

Supplementary files

Article information

Article type
Paper
Submitted
30 mar 2024
Accepted
16 jul 2024
First published
16 jul 2024
This article is Open Access
Creative Commons BY license

Nanoscale, 2024,16, 14853-14860

High-load nanoparticles with a chemotherapeutic SN-38/FdUMP drug cocktail

K. Sabljo, M. Ischyropoulou, J. Napp, F. Alves and C. Feldmann, Nanoscale, 2024, 16, 14853 DOI: 10.1039/D4NR01403K

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