Issue 5, 2024

Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

Abstract

Potassium channels represent the most prevalent class of ion channels, exerting regulatory control over numerous vital biological processes, including muscle contraction, neurotransmitter release, cell proliferation, and apoptosis. The seamless integration of astonishing functions into a sophisticated structure, as seen in these protein channels, inspires the chemical community to develop artificial versions, gearing toward simplifying their structure while replicating their key functions. In particular, over the past ten years or so, a number of elegant artificial potassium transporters have emerged, demonstrating high selectivity, high transport efficiency or unprecedented transport mechanisms. In this review, we will provide a detailed exposition of these artificial potassium transporters that are derived from a single molecular backbone or self-assembled from multiple components, with their respective structural designs, channel functions, transport mechanisms and biomedical applications thoroughly reviewed.

Graphical abstract: Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

Article information

Article type
Feature Article
Submitted
10 sep 2023
Accepted
07 dec 2023
First published
08 dec 2023

Chem. Commun., 2024,60, 482-500

Artificial transmembrane potassium transporters: designs, functions, mechanisms and applications

X. Yuan, J. Shen and H. Zeng, Chem. Commun., 2024, 60, 482 DOI: 10.1039/D3CC04488B

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