Issue 21, 2023

Ginsenoside Rg1 modulates vesicular dopamine storage and release during exocytosis revealed with single-vesicle electrochemistry

Abstract

Ginsenoside Rg1, a tetracyclic triterpenoid derivative extracted from the roots of Panax ginseng C. A. Meyer, can enhance learning and memory and improve cognitive impairment. However, whether or how it affects vesicular dopamine storage and its release during exocytosis remains unknown. By using single-vesicle electrochemistry, we for the first time find out that Rg1 not only upregulates vesicular dopamine content but also increases exocytosis frequency and modulates dopamine release during exocytosis in PC12 cells, which may relate to the activation of protein kinases, causing a series of biological cascades. This finding offers the possible link between Rg1 and vesicular chemical storage and exocytotic release, which is of significance for understanding the nootropic role of Rg1 from the perspective of neurotransmission.

Graphical abstract: Ginsenoside Rg1 modulates vesicular dopamine storage and release during exocytosis revealed with single-vesicle electrochemistry

Supplementary files

Article information

Article type
Communication
Submitted
21 dec 2022
Accepted
14 feb 2023
First published
14 feb 2023

Chem. Commun., 2023,59, 3087-3090

Ginsenoside Rg1 modulates vesicular dopamine storage and release during exocytosis revealed with single-vesicle electrochemistry

J. Zhou, J. Zhang, L. Cao, Y. Liu, L. Liu, C. Liu and X. Li, Chem. Commun., 2023, 59, 3087 DOI: 10.1039/D2CC06950D

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