Issue 10, 2022

A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells

Abstract

Precise control of luminescence and singlet oxygen generation is important for selective photo-theranostic applications. In this work, bioorthogonal assembly based on d10⋯d10 metallophilic interactions was first proposed for selective cancer cell imaging and photodynamic therapy (PDT) treatment as a proof of concept. [Au(NHC)2]+ (NHC = N-heterocyclic carbene) cations loaded on hyaluronic acid were selectively taken up by cancer cells. The subsequent incubation with [MX2] (M = Au or Cu and X = halide or arylacetylide) anions led to the bioorthogonal assembly of C3 + A5/A10 in cancer cells with luminescence turn-on and singlet oxygen generation upon irradiation. This work not only demonstrates that d10⋯d10 metallophilic interactions can be readily harnessed for developing bioorthogonal assembly to realize precise cancer cell imaging and PDT, but also can stimulate the development of supramolecular interaction based bioorthogonal chemistry.

Graphical abstract: A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells

Supplementary files

Article information

Article type
Research Article
Submitted
18 jan 2022
Accepted
25 mar 2022
First published
25 mar 2022

Inorg. Chem. Front., 2022,9, 2290-2297

A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells

X. Da, F. Yu, C. Zhang, Z. Wang, Y. Jian, Y. Hou, Y. Chen, X. Wang and Q. Zhou, Inorg. Chem. Front., 2022, 9, 2290 DOI: 10.1039/D2QI00147K

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