Issue 10, 2018

Hydrogels based on pH-responsive reversible carbon–nitrogen double-bond linkages for biomedical applications

Abstract

Covalently-crosslinked hydrogels are formed due to the generation of new covalent crosslinking bonds in situ, leading to the formation of covalently-linked networks. However, traditional polymerization might introduce potential toxicity issues. Recently, carbonyl-condensation reactions that form imine, hydrazone or oxime bonds have become important tools for the preparation of covalently-crosslinked hydrogels for biomedical applications. The formation of imine, hydrazone or oxime linkages occurs under mild conditions with water as the only byproduct. The reactions are reversible and pH-responsive, and are dependent on the chemical structure of the substrates. In this review, we focus on the utilization of the condensation reactions between nucleophiles and carbonyl groups as crosslinking strategies to prepare hydrogels with physiochemical properties sensitive to biologically relevant stimuli. A brief account of the formation mechanisms and stabilities of these linker moieties will help to understand how reactant structure controls the gelation and degradation of hydrogels. Natural and synthetic polymers that are commonly employed as building blocks and synthetic methods that are selected for decoration of different polymers with respective functional groups will be summarized. Then, the preparation and biomedical applications of the hydrogels based on imine/hydrazone/oxime formation will be presented respectively, with special focus on the developments in the past decade. This review will provide insight into the design of novel biocompatible, stimuli-responsive hydrogels based on dynamic linkages for various biomedical applications.

Graphical abstract: Hydrogels based on pH-responsive reversible carbon–nitrogen double-bond linkages for biomedical applications

Article information

Article type
Review Article
Submitted
01 jul 2018
Accepted
28 avg 2018
First published
01 sep 2018

Mater. Chem. Front., 2018,2, 1765-1778

Hydrogels based on pH-responsive reversible carbon–nitrogen double-bond linkages for biomedical applications

Z. Zhang, C. He and X. Chen, Mater. Chem. Front., 2018, 2, 1765 DOI: 10.1039/C8QM00317C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements