Issue 50, 2018
From the journal:

Chemical Communications

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications†

Paige J. LeValley,‡a   Elisa M. Ovadia,‡a   Christopher A. Bresette,a   Lisa A. Sawicki,a   Emanual Maverakis,b   Shi Baic  and  April M. Kloxin ORCID logo *ad  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE 19716, USA
E-mail: akloxin@udel.edu

b Department of Dermatology, School of Medicine, University of California Davis, Davis, CA 95616, USA

c Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA

d Department of Material Science and Engineering, University of Delaware, Newark, DE 19716, USA

Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol–ene and strain promoted azide–alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Graphical abstract: Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CC03218A
Article type
Communication
Submitted
27 apr 2018
Accepted
24 maj 2018
First published
29 maj 2018

Chem. Commun., 2018,54, 6923-6926

Permissions

Request permissions

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

P. J. LeValley, E. M. Ovadia, C. A. Bresette, L. A. Sawicki, E. Maverakis, S. Bai and A. M. Kloxin, Chem. Commun., 2018, 54, 6923 DOI: 10.1039/C8CC03218A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements