Issue 9, 2018

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

Abstract

Pt(IV) prodrugs are a class of promising anticancer agents, which are activated by reduction to the active Pt(II) species. Consequently, the reduction process is a crucial parameter. Herein, a new approach using electrochemistry (EC) coupled to liquid chromatography (LC) and electrospray ionization-mass spectrometry (ESI-MS) or inductively coupled plasma (ICP)-MS was applied. This enabled getting insights into the differences in the reduction and ligand release of platinum(IV) complexes with varying equatorial core structures.

Graphical abstract: Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

Supplementary files

Article information

Article type
Communication
Submitted
09 feb 2018
Accepted
29 mar 2018
First published
09 apr 2018
This article is Open Access
Creative Commons BY license

Analyst, 2018,143, 1997-2001

Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS)

L. M. Frensemeier, J. Mayr, G. Koellensperger, B. K. Keppler, C. R. Kowol and U. Karst, Analyst, 2018, 143, 1997 DOI: 10.1039/C8AN00258D

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