Issue 61, 2017

Dual modal imaging agents based on chromophore-bearing DTPA analogues

Abstract

Two new DTPA analogues, centrally (L1) and terminally (L2) functionalised with a 1,8-naphthalimide chromophore, have been successfully prepared and fully characterized. Their Gd(III) complexes have also been prepared and evaluated for their ability to act as dual modal contrast agents (MRI/OI). The highly reproducible R1 relaxivity of L1 (8.10 ± 0.21 mM−1 s−1, 25 °C and 30 MHz) is markedly higher than other DTPA based contrast agents. The Gd(III) complexes of both L1 and L2 have been evaluated as luminescence probes; the ligand based fluorescence is not quenched upon complexation.

Graphical abstract: Dual modal imaging agents based on chromophore-bearing DTPA analogues

Supplementary files

Article information

Article type
Paper
Submitted
21 jun 2017
Accepted
28 jul 2017
First published
04 avg 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 38463-38470

Dual modal imaging agents based on chromophore-bearing DTPA analogues

C. Sathiyajith, A. J. Hallett, A. J. Amoroso and P. G. Edwards, RSC Adv., 2017, 7, 38463 DOI: 10.1039/C7RA06946D

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