Issue 38, 2014

Cs2CO3 promoted direct C–H bond sulfenylation of imidazo[1,2-a]pyridines and related heteroarenes in ionic liquid

Abstract

An efficient and novel method was developed for the synthesis of 3-sulfenyl imidazo[1,2-a]pyridines in good to excellent yields via a Cs2CO3 promoted direct sulfenylation of imidazo[1,2-a]pyridines. The reaction proceeds smoothly with a wide range of structurally diverse heteroarenes and disulfides. This protocol is environmentally friendly because it is free of transition-metal catalysts and utilizes aryl-substituted imidazolium-based ionic liquid rather than volatile organic solvents.

Graphical abstract: Cs2CO3 promoted direct C–H bond sulfenylation of imidazo[1,2-a]pyridines and related heteroarenes in ionic liquid

Supplementary files

Article information

Article type
Paper
Submitted
12 feb 2014
Accepted
17 apr 2014
First published
25 apr 2014

RSC Adv., 2014,4, 19891-19895

Cs2CO3 promoted direct C–H bond sulfenylation of imidazo[1,2-a]pyridines and related heteroarenes in ionic liquid

Z. Gao, X. Zhu and R. Zhang, RSC Adv., 2014, 4, 19891 DOI: 10.1039/C4RA01240B

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