Issue 8, 2013
From the journal:

Journal of Materials Chemistry B

Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs†

Wei Li Lee,‡a   Peixin Wee,‡a   Chandra Nugrahaa  and  Say Chye Joachim Loo*a  

* Corresponding authors

a School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore
E-mail: joachimloo@ntu.edu.sg
Fax: +65 6790-9081
Tel: +65 6790-4603

Abstract

Floating polymeric microcapsules that simultaneously entrap multiple drugs were prepared using a solid/water/oil/water emulsion solvent evaporation method, based on harnessing interfacial phenomena and manipulation of the solvent removal process. The fabricated microcapsules exhibited excellent buoyancy in simulated gastric fluid and provided controlled and sustained release of multiple drugs for up to 24 h, thus revealing their potential as a rate-controlled oral drug delivery system.

Graphical abstract: Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

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Article information

DOI
https://doi.org/10.1039/C2TB00495J
Article type
Communication
Submitted
06 dec 2012
Accepted
03 jan 2013
First published
08 jan 2013
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2013,1, 1090-1095

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Gastric-floating microcapsules provide controlled and sustained release of multiple cardiovascular drugs

W. L. Lee, P. Wee, C. Nugraha and S. C. J. Loo, J. Mater. Chem. B, 2013, 1, 1090 DOI: 10.1039/C2TB00495J

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