Themed collection 2022 Organic Chemistry Frontiers Review-type Articles

Behaviors of typical organogermanium(IV) compounds in photo-induced reactions are reviewed.

This review summarizes the recent advances in the synthetic application of iodonium ylides covering 2017 to 2022.

This review summarizes the recent advances in the bioinspired synthesis of cytochalasans, pentacyclic cytochalasans and merocytochalasans covering from 2016 to 2021.

This review updates the field of enantioselective nickel-catalyzed conjugate additions since 2016.

Transition metal-catalyzed carbonylation has emerged as a powerful and versatile strategy for the efficient construction of complicated carbonyl-containing molecules from simple chemical feedstocks in the past decades.

This review systematically summarizes the recent developments for constructing sulfur compounds from sulfur electrophiles, and the mechanism mainly involved thirranium ions, sulfur ylides, C–S cross coupling and electrophilic substitution.

In this review article, we summarize novel or non-standard strategies and methods for the five-membered carbocycle construction in recent Daphniphyllum alkaloid synthesis.

Synthetic approaches for 2,4,6-trisubstituted-1,3,5-triazine systems are analyzed, and their properties attractive to practical applications in fluorescent materials are reviewed.

Recent advances with calix[4]pyrrole-based supramolecular functional entities in the fields of molecular recognition (receptors, sensors, and metal ion caged systems), self-assembly (polymers), photo/pH-responsive molecular switches and catalysis are reviewed.

This review aims to highlight the recent advances in the area of radical type silylation reactions mediated by photo- and electrocatalysis.

This review summarizes the development status of chiral TADF-active materials with CPEL, covering chiral perturbed TADF molecules, intrinsically chiral TADF molecules, and TADFsensitized fluorescent enantiomers.

Since 2004, chiral phosphoric acids (CPAs) have emerged as highyl efficient organocatalysts, providing excellent results in a wide reaction scope. In this review, the applications of CPA for enantioselective additions to CO and CN bonds are covered.

Hydrazines are versatile building blocks in organic synthesis.

This review summarized the applications of sulfinyl radicals in organic chemistry and thoroughly examined the challenges and future development trends of sulfinyl radicals in modern organic chemistry, as well as their structures and properties.

This review provides a journey of the catalyst usage for the enantioselective conjugate addition of nitroalkanes to electron-poor olefins from the early attempts to the latest achievements. Selected applications are also reported.

This review focuses on the thermodynamics of the elementary step of 421 organic hydrides and unsaturated compounds releasing or accepting hydride or hydrogen determined in acetonitrile as well as their potential applications.

Recent progress in the synthesis of zig-zag-fused BODIPY, structure–property relationships, as well as their applications are summarized.

This review summaries a view of the advances in the cascade reactions of enynols/diynols for the construction of carbo- and heterocycles.

C(sp³)–H functionalization is attracting constant attention. This review emphasizes C-centered radicals initiated cyclization strategies by directed C(sp³)–H oxidative functionalization since 2012.

Dioxiranes are extremely useful multitasking agents for a broad spectrum of chemical transformations. This review collates the history of dioxiranes over the last fifty years in the realm of organic and materials chemistry.

We give an overview of the reported synthetic strategies towards partially methylated glycosides and discuss how better protocols could stem from catalytic site-selective transformations of carbohydrates and cleaner methylation reagents.

The synthetic utility of rearrangement reactions in total synthesis for the rapid construction of core skeletons, the precise control of stereochemistry, and the identification of suitable synthons has been discussed.

This critical review aims to provide an overview of oxidative phenol and naphthalenol transformations in nature and synthetic chemistry.

In this review, the advances made over the last 6 years in [4 + 1]-annulation reactions involving sulfonium, sulfoxonium and ammonium ylides, as well as diazo compounds and carbenes are summarized.

The review highlights the transition metal-free methodologies developed for synthesising various heterocyclic compounds by utilising α,β-unsaturated ketones as valuable synthons during the period of 2009 to 2020.

This review highlights the encouraging advances in hydride transfer-involved dearomatization reaction during the past decade, the content of which is categorized according to the hydride acceptors, namely vinylogous imines and quinone methides.

Recent advances in the metal-catalyzed asymmetric synthesis of chiral allenes are summarized. This review is categorized based on the starting material, including alkynes, racemic allenes, and conjugated dienes.

The nickel-catalyzed hydroarylation reaction opens up new routes to access complex organic compounds in a highly regio and stereoselective fashion from easily available precursors, such as olefin, alkyne, arene, aryl halide, and aryl boronic acid.

This article takes an in depth look at the early relay combination of NHC and other catalysts, and the latest progress in dual catalysis, analyzing the breakthroughs and limitations.

This review covering the recent advances of asymmetric 1,3-rearrangement reactions is divided into four different fields, including transition metal catalysis, nucleophilic catalysis, Brønsted acid catalysis and Lewis acid catalysis.

Usually, multiple [n]helicene molecules have a characteristic aromatic core, such as benzene, naphthalene, pyrene, perylene, hexabenzocoronene, corannulene, or azacorannulene.

Radical strategies for preparation of seven- or eight-membered rings.

In this minireview, we evaluate and summarize the construction of axially chiral biaryls, and briefly state our personal perspectives on the future advancement of this direction.

This review summarizes the recent development of remote C(sp³)–H bond or aldehydic C(sp²)–H functionalizations enabled by intermolecular radical addition to CC bond/(1,n)-HAT tandem sequences.

Transformations among Stemona alkaloids with different ring systems have improved the synthetic efficiency toward diverse alkaloids. Recent advances in the transformations of different types of Stemona alkaloids were reviewed for the first time.

In this review, we summarize the state-of-the-art advances in difluoromethylation of heterocycles via a radical process over the past few years (2018 to early 2022).

MCRs as privileged and practical synthetic route, have been deployed for preparation of COFs. Subsequently, proficient COFs as robust catalysts have been employed for the sustainable MCRs.

This review summarizes recent advances in the use of isocyanide as “C1N1” synthons in cyclization.

This review introduces seven types of cyclization reactions via C–H activation using a transient directing strategy.

Iodonitrene is a new type of reactive electrophilic aminating reagent that opens up opportunities for new discoveries.

Recent advances in partial reductions of inert carboxylic acids and their derivatives to active aldehydes are reviewed.

Anti-inflammatory bioactivity of diversely substituted indole derivatives, mainly N-1 and C-3 substituted indoles.

The combination of visible light photoredox catalysis with direct difluoromethylation has allowed the synthesis of a large choice of CF₂H-containing value-added molecules under very mild reaction conditions.

Recent developments of diphenyl phosphorazidate (DPPA, (C6H5O)2P(O)N3) has been reviewed.

The review presents rare-earth metal-catalyzed C(sp²/sp³)–H functionalization accessing C–C/C–heteroatom bonds and olefin (co)polymerization, highlighting substrate scope, mechanistic realization, and origin of site-, enantio-/diastereo-selectivity.

This review summarizes the growing landscape in the reactions of silacyclobutanes (SCBs) by highlighting fascinating progress, deconstructing mechanistic underpinnings, and drawing insight from related ring-opening and expanding reactions of SCBs.

The most important advance in photocatalysis in the last decade has been the synthesis and application of organic compounds to promote this process.

We highlighted the recent advances in the field of central-to-axial chirality transfer for the synthesis of axially chiral molecules.

In this review article, we summarized recent advances in the transition metal-catalyzed heteroannulative difunctionalization of alkenes via direct C–H activation to access heterocyclic frameworks.

We highlighted the recent advances in the field of multiple-fold C–F bond functionalization for the synthesis of (hetero)cyclic compounds.

A comprehensive review overviewing the advances in Rh-catalyzed cross-dehydrogenative-coupling in the period of 2016–2021 is presented.

β-Nucleosides are fundamental building blocks of biological systems and are used as therapeutic agents for the treatment of cancer and viral infections. This review summarizes the stereoselective synthesis of β-nucleosides and their analogues.

This review focuses on the advances in transition-metal catalyzed reactions with fluorinated building blocks via directed C–H bond activation for the construction of diverse organic molecules with an insight into the probable mechanistic pathway.

Recent advances in transition-metal-catalyzed enantioselective desymmetric C–H functionalization are summarized.

Visible light and photoredox catalysis have emerged as a powerful and long-lasting tool for organic synthesis, demonstrating the importance of a variety of chemical bond formation methods.

Transition-metal-free trifluoromethylations have attracted significant research interest driven by the increasing importance of CF₃-containing compounds.

The recent advances in total synthesis of indole natural products focusing on the application of C–H bond functionalization are summarized.