Themed collection New Talent

In the current review, we have compiled the reports on the use of sulfoxonium ylides in metal-catalyzed C–H activation either as a coupling partner or as a directing group. These are further subdivided based on the metal-catalyst employed.

This review highlights the recent advances in the use of MFA (molecular field analysis) for data-driven catalyst design, enabling to improve selectivity in asymmetric catalysis.

Transition metal catalysed C–S bond formation from unreactive C–H bonds is a remarkable tool in the late-stage functionalization of complex molecules. This review highlights significant advances and mechanistic analyses from the last two decades.

This review article contains various synthetic strategies for the generation of pyridines, quinolines, and isoquinolines from the propargylic alcohols during the period between 2005–2021. This is the first focused review that has appeared on this topic.

The review discusses recent advances in electrocatalytic radical coupling reactions involving carbon-centered radical species.

This review discusses the application of genetically-encodable biosensors toward enzyme directed evolution.

Herein we disclose the chemically unique features of the pyridazinedione scaffold and how these have been applied in various bioconjugation methodologies.

A route to functionalized benzo[e]indolones has been reported via (3 + 2) cycloaddition of in situ generated azaoxyallyl cations with alkoxynaphthalene followed by aryl C–O bond cleavage. The intermediate adduct has been isolated and characterized.

In this report, we demonstrate that visible light photoactivation of 6-bromo-2-naphthol facilitates the photoacid-catalyzed acetalization of carbonyls with alcohols.

A slight rate enhancement for substitution reactions on P results from electrostatic interactions with an ortho-Bpin group.

MoPt alloy in Mo–Pt/SiO₂ catalyst was effective for the hydrogenation of n-octanoic acid to 1-octanol at a low reaction temperature of 373 K under neat reaction conditions.

A concise total synthesis of racemic mersicarpine is achieved featuring an application of a 6-exo-trig radical cyclization of a 2-indolyl radical.

A new protocol for the fluorination of various α-diazo carbonyl compounds is reported employing HF·pyr (Olah reagent). The method can be performed open-flask, is metal-free, and shows a broad scope.

In this manuscript, we report a new strategy to access α-(hetero)arylnitriles from malononitrile, a commodity chemical. The reaction proceeds through a one-pot decyanation (via transnitrilation) and subsequent nucleophilic aromatic substitution.

Sydnonimine fluorogenic probes with a high turn-on ratio were designed and synthesized, releasing near-infrared fluorescence via a strain-promoted “click-and-release” reaction.

We developed a novel copper-catalyzed benzolactone synthesis via 1,5-HAT of amidyl radicals from 2-alkylbenzamides under O₂ atmosphere.

The total synthesis of (±)-vinoxine was achieved featuring the assembly of a substituted tetrahydropyrido[1,2-a]indole skeleton through the Tf₂O-mediated Bischler–Napieralski reaction.

A visible-light-mediated oxidative C–S bond cleavage of benzyl thiols through an in situ activation strategy was developed.

Using synthetic oligosaccharides, we examined how deoxyfluorination (site and pattern) impact the solubility and aggregation of cellulose and chitin oligomers.

The first cellular application of cationic styrylthiazolium photopharmaceuticals highlights powerful photochemistry, and subcellular phototargeting of inhibition.

Fluorogenic ATRP from initiator-modified protein enables visual, real-time detection of polymer formation in bioorthogonal fashion by removal of monomer α,β-unsaturation.

A two-component reductive amination protocol enables the macrocyclisation of unprotected peptide diamines with functionalised pyridinedialdehyde linkers.

A late-stage α-C–H functionalization reaction of resin-bound, electron-rich N-aryl peptides with boronic acid nucleophiles under mild conditions is reported.

Herein we report our study on the development of a catalytic one-pot process, showing the challenges and advantages encountered all over the way.

The synthesis and evaluation of a new ATP-independent bioluminescent probe for H₂O₂ detection is described and applied toward intra- and extracellular detection in a breast cancer cell model.

Heterochiral Phe–Val self-assembles into water-channels and forms a cell-biocompatible hydrogel biomaterial.

Computational structural investigation (CSI) points to a new primary suspect as the general base in pistol ribozyme catalysis.

We investigated the photochemistry of ternary complexes of a cucurbit[8]uril host and donor–acceptor stilbene guests. We found that slow back electron transfer rates allow [2 + 2] photocycloadditions to proceed after photoinitiated charge transfer.

We present a general strategy for activation of N–C(S) thioamide bonds by ground-state-destabilization in the context of a full study on transamidation of thioamides with nucleophilic amines.

Studies of two organocatalyzed 1,3-dipolar cycloadditions are provided, with investigation of the elementary steps, intermediates, and transition states in terms of DFT calculations, supported by ¹H NMR monitoring, along with DIAS analysis.

Multivariate logistic regression models can be developed and utilized as a strategy to streamline the reaction optimization process.

Sulfonated rhodamine dyes allow SNAP- and Halo-tag labelling of cell surface protein fusions. A far-red version can be used for STED nanoscopy.

Assembling methods using 2-azidoacrylamides having an amino group are disclosed, and they were used to synthesize 2-azidoacrylamides having a fluorosulfonyl group. We achieved consecutive click reactions using the new trivalent platform.

A microplate reader assay to enable the characterisation of amphiphile self-assembly processes and derivation of the critical micelle concentration (CMC).

Azoarene photoswitches are versatile molecules that interconvert from their E-isomer to their Z-isomer with light.

Various small molecules containing boronic acid and urea functionalities are shown to bind selectively to the bacterial lipid PG (phosphatidylglycerol) and exert antibacterial activity through a membrane-related mechanism.