Themed collection CrystEngComm up-and-coming articles

MOF/COF hybrids combine the outstanding features of MOF and COF structures, such as high crystallinities, large surface areas, high porosities, and improved chemical and mechanical stabilities.

This work highlights recent advances in the diagnosis, prevention, and control of impurity incorporation during solution crystallization.

This highlight presents an overview of pharmaceutical cocrystal production and its potential in reviving problematic properties of drugs in different dosage forms. The challenges and future outlook of its translational development are discussed.

The heavier chalcogen atoms S, Se, and Te can each participate in a range of different noncovalent interactions. They can serve as both proton donor and acceptor in H-bonds. Each atom can also act as electron acceptor in a chalcogen bond.

Flexible molecular crystals have attracted much attention to unique optoelectronic applications and stimuli-responsive chemistry, resulting in various functional molecular crystals for controlling photons, phonons, electrons, and magnons.

Crystal adaptronics has undergone tremendous developments that have been utilized to rationalize dynamics in crystals. This highlight discusses about the role of intermolecular interactions in rationalizing mechanical responses in crystals.

This highlight presents an overview of the current advances in the preparation of halogen bonded metal–organic multi-component solids, including salts and cocrystals comprising neutral and ionic constituents.

This study outlines a systematic approach to control the polymorphism of carbamazepine (CBZ) and isolate the metastable polymorph CBZ form IV as a function of droplet size using spray drying as a continuous method of manufacture.

A method for routine molecular crystal structure determination on very small (typically <0.1 mg) amounts of crystalline material using powder X-ray diffraction data from a laboratory-based single-crystal diffractometer is reported.

We present the use of artificial intelligence to predict the morphology of crystallizing active pharmaceutical ingredients, first using publicly available data, and then using our own screening efforts to address the limitations we identified.

Three cocrystals were obtained by naproxen and acridines, optimizing the yield to more than 99% with LAG. The two structures by solution show a host-guest structure, while that by LAG a layered one, with no interconversion between parent structures.

Crystallization mechanisms were proposed to investigate hydrogen bond and aromatic donor–acceptor interactions in a series of phenyl–perfluorophenyl amides. The modulation of NH⋯OC bonds and aryl complementarity drove a new cocrystal growth.

For the first time mercaptopyridine co-crystals are reported as a result of the cross-crystallization of two mercaptopyridines with thiourea and trithiocyanuric acid. In one case, the co-crystal was needed to be obtained under dark room conditions.

Series novel 3D Ln-MOFs containing both carboxyphenyl and pyridinyl moieties have been constructed. Tb-MOF fluorescence turn-on sensor of levofloxacin solution with highly sensitive and excellent selective was achieved through d-PET approach.

We demonstrate here using a disulfide system the first example of reversible, selective, and quantitative transformation between three crystalline polymorphs by ball mill grinding.

The oxygen atom of the MOF ether-bridging group acts as a Lewis base site, improving the connection and allowing the detection of 10 antibiotics through the fluorescence quenching effect.

A 3D pillar-layered cobalt(II) CP with a 3D (4,6)-connected {4⁴·6¹⁰·8}{4⁴·6²} fsc net was designed and it showed great potential as an electrocatalyst in the overall water splitting and as a chemosensor for Cr(VI) anion detection.

A benzothiadiazole-based Zn^II MOF (JXUST-3) has been synthesized, which is a good multifunctional chemosensor for the detection of Al³⁺, Cr³⁺ and Fe³⁺.

Four Zn-MOFs with different topological types were synthesized and characterized, MOFs 1–4 have excellent sensitivity, selectivity, recyclability and structural stabilities for detecting acac/Fe³⁺ in the naked eye range.

Four Zn(II)/Co(II) CPs act as bifunctional materials in the detection of Fe(III) cation, Cr(VI) anion, and nitrofuran antibiotics and removal of methylene blue in aqueous media.

Both the MOFs proved to be good candidates for the photocatalytic degradation of methyl violet. The mechanism of these photocatalytic degradations is discussed.