Themed collection 2022 CRSI Medal Winners Collection
Recent advances in transition metal-mediated trifluoromethylation reactions
This review provides a complete demonstration of amalgamating significant pieces of work in the metal-mediated trifluoromethylation genre of recent past years.
Chem. Commun., 2022,58, 10442-10468
https://doi.org/10.1039/D2CC04082D
Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance
We describe design and syntheses of a new generation of exceptionally highly potent non-peptidic HIV-1 protease inhibitors.
Chem. Commun., 2022,58, 11762-11782
https://doi.org/10.1039/D2CC04541A
Unraveling the origin of the cooperative adsorption of carbon monoxide in an Fe(II) metal–organic framework
Using periodic DFT calculations, we unveil the mechanism of cooperative CO adsorption in an Fe(II) bistriazolate MOF, where both structural distortion and electronic effects are found to play an active role.
Chem. Commun., 2023,59, 10315-10318
https://doi.org/10.1039/D3CC01185B
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
A new class of 5′-morpholino modified nucleoside building blocks was synthesized. Among them, Mo2 exhibited better off-target mitigation for RNAi compared to other analogues Pip and Mo3 and the previously reported morpholino derivative Mo1.
Chem. Commun., 2023,59, 6347-6350
https://doi.org/10.1039/D3CC01143G
Palladium-catalyzed remote meta-C–H olefination of cinnamates
Palladium-catalyzed novel remote meta-C–H olefination of geometrically challenging cinnamates using nitrile directing group derived from 2-cyanobenzoic acid has been described. A variety of bioactive molecules tethered acrylates have been coupled.
Chem. Commun., 2023,59, 5249-5252
https://doi.org/10.1039/D3CC00289F
Palladium-catalyzed intramolecular oxypalladation-initiated cascade: solvent-dependent chemodivergent approach to functionalized benzazepines and tetrahydroquinolines
A palladium-catalyzed, solvent-dependent, intramolecular oxypalladation-initiated chemodivergent approach was established for the synthesis of functionalized benzazepines and tetrahydroquinolines.
Chem. Commun., 2023,59, 5233-5236
https://doi.org/10.1039/D3CC01370G
Visualization of domain structure and piezoelectric energy harvesting in a ferroelectric metal–ligand cage
A metal–organic cage exhibits ferro- and piezoelectric properties as visualized by its domain structure using PFM and utility in piezoelectric energy harvesting properties. This is a rare observation in supramolecular metal–organic cages.
Chem. Commun., 2023,59, 2919-2922
https://doi.org/10.1039/D3CC00098B
Comparing the reactivity of an oxoiron(IV) cation radical and its oxoiron(V) tautomer towards C–H bonds
An oxoiron(IV) cation radical is generated upon two-electron oxidation of an iron(III) complex bearing an electron-rich methoxy substituted bTAML framework and characterized via multiple spectroscopic techniques and density functional theory (DFT).
Chem. Commun., 2023,59, 2755-2758
https://doi.org/10.1039/D2CC07005G
Temperature driven charge transfer process in quantum confined two-dimensional Mn-doped CsPbBr3 perovskite nanoplatelets
Understanding of the energy/charge transfer processes in Mn–CsPbBr3 NPLs is achieved using temperature-dependent femtosecond TA spectroscopy. Charge transfer process which is efficient at 300 K is seen to be inhibited at 5 K.
Chem. Commun., 2022,58, 13899-13902
https://doi.org/10.1039/D2CC05142G
Pd(II)-catalyzed annulation of terminal alkynes with 2-pyridinyl-substituted p-quinone methides: direct access to indolizines
A Pd-catalysed 100% atom-economical method has been developed for the synthesis of 1,3-disubstituted indolizine derivatives in good yields through a regiospecific formal [3 + 2]-annulation from 2-pyridinyl-substituted p-quinone methides and terminal alkynes.
Chem. Commun., 2022,58, 13238-13241
https://doi.org/10.1039/D2CC04395E
Residue-specific N-terminal glycine to aldehyde transformation renders analytically pure single-site labeled proteins
Here, we demonstrate the residue-specific transformation of N-Gly into N-Gly-glyoxamide. The aldehyde introduction opens the residue-specific synthetic flexibility for the N-Gly proteome.
Chem. Commun., 2022,58, 12451-12454
https://doi.org/10.1039/D2CC04196K
A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones
Herein, we report a Pd(0)-catalyzed cascade reaction with multifunction of isocyanide as a nucleophile promoter for rearrangement and a hydride source.
Chem. Commun., 2022,58, 11827-11830
https://doi.org/10.1039/D2CC04273H
Configurational ligand isomerism in conjoined-cages
Isomeric coordination complexes of different configurations (hour-glass and double-decker) but prepared from regioisomeric tridentate ligands are described.
Chem. Commun., 2022,58, 8480-8483
https://doi.org/10.1039/D2CC02837A
Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes
The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described.
Chem. Commun., 2022,58, 8424-8427
https://doi.org/10.1039/D2CC02781J
About this collection
This special collection showcases research carried out by some of the 2022 Chemical Research Society of India (CRSI) medal winners. These medals seek to recognise Indian researchers who have contributed significantly at various levels in Chemistry. Please join us in celebrating their success!