Themed collection Biomaterials Science Recent HOT Articles
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Wireless control of nerve growth using bipolar electrodes: a new paradigm in electrostimulation
Wired electrodes for nervous system stimulation have inherent limitations. Electrostimulation using unwired bipolar electrodes offers a new paradigm to drive growth and repair of nervous tissue. It also opens a wide field for innovation of electrode materials and protocols.
Biomater. Sci., 2024,12, 2180-2202
https://doi.org/10.1039/D3BM01946B
Tumor-derived microvesicles for cancer therapy
Extracellular vesicles (EVs) are vesicles with lipid bilayer structures shed from the plasma membrane of cells.
Biomater. Sci., 2024,12, 1131-1150
https://doi.org/10.1039/D3BM01980B
The foreign body response: emerging cell types and considerations for targeted therapeutics
The emerging role of T cells, stromal cells, and senescent cells and their interactions with other cell types in the FBR are discussed in this review. Additionally, factors that modulate the phenotype of these cells are briefly considered.
Biomater. Sci., 2023,11, 7730-7747
https://doi.org/10.1039/D3BM00629H
Synthetic nanoparticles for the delivery of CRISPR/Cas9 gene editing system: classification and biomedical applications
The CRISPR/Cas9 systems contain three modes: I. plasmid DNA encoding both Cas9 and sgRNA; II. Cas9 mRNA and sgRNA; III. Cas9 protein and sgRNA. We summarized the application of the synthesized nanomaterials for delivery the CRISPR/Cas9 systems.
Biomater. Sci., 2023,11, 5361-5389
https://doi.org/10.1039/D3BM00788J
Biomaterial-assisted targeted and controlled delivery of CRISPR/Cas9 for precise gene editing
Development of a novel biomaterial-based CRISPR-Cas9 system for the precise control of genome editing.
Biomater. Sci., 2023,11, 3762-3783
https://doi.org/10.1039/D2BM01636B
Nanoparticle based medicines: approaches for evading and manipulating the mononuclear phagocyte system and potential for clinical translation
Nanomedicine recognition and clearance by the mononuclear phagocyte system (MPS) impedes optimal clinical impacts for this class of materials. We present an overview of factors involved in MPS interactions and approaches to overcome this barrier.
Biomater. Sci., 2022,10, 3029-3053
https://doi.org/10.1039/D2BM00181K
ABCD of IA: A multi-scale agent-based model of T cell activation in inflammatory arthritis
The study develops a computational framework to model factors that lead to the evolution of autoreactive T cells in inflammatory arthritis. The results provide a tool for planning immunomodulatory strategies focused on new disease-modifying agents.
Biomater. Sci., 2024,12, 2041-2056
https://doi.org/10.1039/D3BM01674A
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Gelatine–collagen photo-crosslinkable 3D matrixes for skin regeneration
Immediate care of skin wounds and burns is essential to repair this mechanical and chemical barrier to infections.
Biomater. Sci., 2024,12, 1738-1749
https://doi.org/10.1039/D3BM01849K
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Comparative analysis of supercritical fluid-based and chemical-based decellularization techniques for nerve tissue regeneration
The supercritical (SC) fluid-based method were utilized for nerve tissue decellualrization. In vitro, vivo assessments underscore its potential for advanced tissue engineering and regenerative applications.
Biomater. Sci., 2024,12, 1847-1863
https://doi.org/10.1039/D3BM02072J
A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications
This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.
Biomater. Sci., 2024,12, 1707-1715
https://doi.org/10.1039/D3BM01765F
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Injectable, shear-thinning, photocrosslinkable, and tissue-adhesive hydrogels composed of diazirine-modified hyaluronan and dendritic polyethyleneimine
In the present study, we report the first synthesis of diazirine-modified hyaluronic acid (HA–DAZ).
Biomater. Sci., 2024,12, 1454-1464
https://doi.org/10.1039/D3BM01279D
Aggregation-induced emission photosensitizer microneedles for enhanced melanoma photodynamic therapy
The AIE photosensitiser TPE-EPy@CB[7] was prepared by supramolecular self-assembly, which effectively enhanced the type-I ROS generation capacity. MNs facilitated precise drug delivery and enhanced light penetration into deeper layers of the tumor.
Biomater. Sci., 2024,12, 1263-1273
https://doi.org/10.1039/D3BM01819A
Engineering surgical face masks with photothermal and photodynamic plasmonic nanostructures for enhancing filtration and on-demand pathogen eradication
Development of a light-responsive face mask with enhanced filtration properties and on-demand photodynamic and photothermal-driven pathogen eradication.
Biomater. Sci., 2024,12, 949-963
https://doi.org/10.1039/D3BM01125A
Controlling placental spheroid growth and phenotype using engineered synthetic hydrogel matrices
The human placenta is a complex organ comprised of multiple trophoblast subtypes, and inadequate models to study the human placenta in vitro limit the current understanding of human placental behavior and development.
Biomater. Sci., 2024,12, 933-948
https://doi.org/10.1039/D3BM01393F
Egg microneedles for transdermal vaccination of inactivated influenza virus
The use of egg microneedles (EMN) is a promising transdermal vaccine delivery technique, effectively preserving the vaccine's activity during its dissolution and delivery directly into the skin upon administration.
Biomater. Sci., 2024,12, 907-918
https://doi.org/10.1039/D3BM01635H
Delivery of gefitinib loaded nanoparticles for effectively inhibiting prostate cancer progression
PLGA NPs can serve as an excellent nanoplatform, and GEF@PLGA NPs exhibit tumor-specific responses and high antitumor properties, which may facilitate the use of less toxic GEF in prostate cancer treatment regimens.
Biomater. Sci., 2024,12, 650-659
https://doi.org/10.1039/D3BM01735D
Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery
Alcohol solvents are encapsulated in palm oil-based microcapsules for the effective transdermal delivery of high-content actives.
Biomater. Sci., 2023,11, 7531-7540
https://doi.org/10.1039/D3BM01411H
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Synthetic hyaluronic acid coating preserves the phenotypes of lymphatic endothelial cells
Surface coating with dopamine conjugated hyaluronic acid (HA–DP) can interact with lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) to preserve the phenotypes and functionality of lymphatic endothelial cells (LECs).
Biomater. Sci., 2023,11, 7346-7357
https://doi.org/10.1039/D3BM00873H
Targeted microRNA delivery by lipid nanoparticles and gas vesicle-assisted ultrasound cavitation to treat heart transplant rejection
Despite exquisite immune response modulation, the extensive application of microRNA therapy in treating heart transplant rejection is still impeded by poor stability and low target efficiency.
Biomater. Sci., 2023,11, 6492-6503
https://doi.org/10.1039/D2BM02103J
Vaccine delivery by zwitterionic polysaccharide-based hydrogel microparticles showing enhanced immunogenicity and suppressed foreign body responses
The controlled release of antigens from zwitterionic-modified polysaccharide hydrogel microparticles has been actively pursued to achieve long-lasting immune responses in vaccine development.
Biomater. Sci., 2023,11, 4827-4844
https://doi.org/10.1039/D2BM01960D
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Does non-thermal plasma modify biopolymers in solution? A chemical and mechanistic study for alginate
The mutual interaction between reactive species generated by non-thermal plasma and biopolymers in solution causes oxidative modifications that can have an impact in biomedical applications.
Biomater. Sci., 2023,11, 4845-4858
https://doi.org/10.1039/D3BM00212H
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Structural and mechanical properties of folded protein hydrogels with embedded microbubbles
Globular folded proteins are powerful building blocks to create biomaterials with mechanical robustness and inherent biological functionality.
Biomater. Sci., 2023,11, 2726-2737
https://doi.org/10.1039/D2BM01918C
Development and optimization of an ocular hydrogel adhesive patch using definitive screening design (DSD)
Bioadhesive hydrogel patches based on chemically modified photocrosslinkable polymers with specific physicochemical properties for sealing and repair of ocular injuries.
Biomater. Sci., 2023,11, 1318-1334
https://doi.org/10.1039/D2BM01013E
Fibroblast-targeting polymeric nanovehicles to enhance topical wound healing through promotion of PAR-2 receptor-mediated endocytosis
A smart skin regeneration platform that can enhance their selective cellular uptake to fibroblasts via PAR-2 receptor mediated endocytosis is proposed.
Biomater. Sci., 2023,11, 450-460
https://doi.org/10.1039/D2BM01357F
Tumor-targeting oxidative stress nanoamplifiers as anticancer nanomedicine with immunostimulating activity
GSH depleting prodrugs and ROS generators self-assemble to generate oxidative stress nanoamplifiers that can preferentially kill cancer cells and exert immunostimulating activity.
Biomater. Sci., 2022,10, 6160-6171
https://doi.org/10.1039/D2BM00601D
Photoclick polysaccharide-based bioinks with an extended biofabrication window for 3D embedded bioprinting
The proposed photoclick HC–HN bioink expands the palette of available polysaccharide-based bioinks and greatly extends the biofabrication window to broaden the application opportunities of 3D bioprinting.
Biomater. Sci., 2022,10, 4479-4491
https://doi.org/10.1039/D2BM00632D
In situ forming injectable γ-poly(glutamic acid)/PEG adhesive hydrogels for hemorrhage control
An injectable adhesive hydrogel based on N-hydroxysuccinimide γ-poly(glutamic acid) and 4-armed poly(ethylene glycol) amine showed rapid gelation time, strong mechanical strength, satisfactory burst pressure and excellent hemostatic performance.
Biomater. Sci., 2022,10, 4218-4227
https://doi.org/10.1039/D2BM00525E
Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases
Flash nanotechnology-produced nanomedicines exhibit potent antioxidant and anti-inflammatory properties and could overcome mucosal barrier for oral delivery, resulting in great efficiency in the prevention and treatment of colitis-associated colorectal cancer.
Biomater. Sci., 2022,10, 4156-4169
https://doi.org/10.1039/D2BM00540A
A component-optimized chemo-dynamic nanoagent for enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model
A component-optimized chemo-dynamic nanoagent achieved an enhanced tumour cell-selective chemo-dynamic therapy with minimal side effects in a glioma mouse model.
Biomater. Sci., 2022,10, 4170-4183
https://doi.org/10.1039/D2BM00615D
Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture
Biodegradable peptide polymers display potent and broad-spectrum antibacterial activity in vitro, as well as strong therapeutic potential in vivo, as a promising alternative to antibiotics in aquaculture.
Biomater. Sci., 2022,10, 4193-4207
https://doi.org/10.1039/D2BM00672C
Functionalized boron nanosheets with near-infrared-triggered photothermal and nitric oxide release activities for efficient antibacterial treatment and wound healing promotion
A multifunctional nanoplatform has been developed based on boron nanosheets loaded quaternized chitosan and NO donor N,N′-di-sec-butyl-N,N′-dinitroso-1,4-phenylenediamine for rapid, and effective treatment of pathogenic bacteria.
Biomater. Sci., 2022,10, 3747-3756
https://doi.org/10.1039/D2BM00519K
Plant-inspired Pluronic–gallol micelles with low critical micelle concentration, high colloidal stability, and protein affinity
Plant-inspired gallol-containing surfactants have been successfully incorporated into typical Pluronic® micelles, allowing low critical micelle concentration, great colloidal stability, and exterior enzyme resistance.
Biomater. Sci., 2022,10, 3739-3746
https://doi.org/10.1039/D2BM00630H
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Enhanced human T cell expansion with inverse opal hydrogels
Lymph node-inspired 3D hydrogels with precisely defined porosity were produced, which improve the state-of-the-art T cell proliferation, a procedure that is especially important for novel cellular immunotherapies.
Biomater. Sci., 2022,10, 3730-3738
https://doi.org/10.1039/D2BM00486K
The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid
The polymer dual drug conjugate synthesized by coupling docetaxel (DTX) and docosahexaenoic acid (DHA) with bifunctionalized dextran is selectively accumulated in tumor and nearly eradicates all MCF-7 tumors bearing in nude mice.
Biomater. Sci., 2022,10, 3454-3465
https://doi.org/10.1039/D2BM00337F
Fatty acid-based polymeric micelles to ameliorate amyloidogenic disorders
Fatty acid-tethered polymers were synthesized via RAFT method to explore their potential role in preventing insulin aggregation process. The results endowed fatty acid-tethered polymers with properties to act as novel anti-amyloidogenic agents.
Biomater. Sci., 2022,10, 3466-3479
https://doi.org/10.1039/D2BM00359G
Tailored therapeutic release from polycaprolactone-silica hybrids for the treatment of osteomyelitis: antibiotic rifampicin and osteogenic silicates
Polycaprolactone/silica hybrids offer a dual therapeutic effect: the promotion of bone regeneration thanks to silicate ions and strong antibacterial properties against the risk of osteomyelitis.
Biomater. Sci., 2022,10, 1936-1951
https://doi.org/10.1039/D1BM02015C
Near-infrared aggregation-induced emission nanodots for early diagnosis of tongue squamous cell carcinoma and sentinel lymph node mapping
By developing DPA-TPE-DCM with intense near-infrared fluorescence emission in the aggregation state, AIE materials were used for the first time in the early diagnosis of orthotopic TSCC and SLN mapping in an orthotopic TSCC-bearing mouse model.
Biomater. Sci., 2022,10, 1929-1935
https://doi.org/10.1039/D1BM01976G
Development of anticancer peptides with low hemolysis, high penetrating membrane activity, certain analgesic activity and the synergistic anticancer effect
Amphiphilic cationic anticancer lipopeptide P10 self-assembles into spherical aggregates, which are used as drug carriers to play a synergistic anticancer role, and its anticancer mechanism is presented.
Biomater. Sci., 2022,10, 1724-1741
https://doi.org/10.1039/D1BM02024B
Bionic biphasic composite scaffolds with osteochondrogenic factors for regeneration of full-thickness osteochondral defects
A bionic biphasic composite scaffold with on-demand osteochondrogenic factors facilitated the regeneration of osteochondral defects.
Biomater. Sci., 2022,10, 1713-1723
https://doi.org/10.1039/D2BM00103A
Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis
The local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration via synergistic immunomodulation of osteogenesis and osteoclastogenesis by macrophages.
Biomater. Sci., 2022,10, 1697-1712
https://doi.org/10.1039/D1BM01842F
Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization
In this work, capillary tubes with different diameters were chosen to mimic a confined environment and the effect of space on the self-assembly behavior of short peptides with different oil-water partition coefficients (log P) was investigated.
Biomater. Sci., 2022,10, 1470-1475
https://doi.org/10.1039/D2BM00041E
A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin
We have designed a dual-function microneedle patch that integrates treatment and diagnosis.
Biomater. Sci., 2022,10, 1209-1216
https://doi.org/10.1039/D1BM01834E
Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers
Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.
Biomater. Sci., 2022,10, 947-959
https://doi.org/10.1039/D1BM01846A
Medical gloves modified by a one-minute spraying process with blood-repellent, antibacterial and wound-healing abilities
A kind of blood-repellent mist spray (MS) was proposed to prevent blood adhesion during surgery and played an important role in antibacterial and wound-healing, which could be widely used in the surface modification of various medical gloves.
Biomater. Sci., 2022,10, 939-946
https://doi.org/10.1039/D1BM01212F
About this collection
Welcome to our online rolling collection of the hottest work published in Biomaterials Science. Here we feature recent Biomaterials Science articles highlighted as HOT by the handling editor or our referees.
Congratulations to all the authors whose articles are featured.