Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
Herein, we report a t-BuONa-promoted method for the site-selective silylation of 2H-indazoles.
A [3 + 2] cycloaddition reaction utilizing cyclic diaryl λ3-bromanes and α-diazo esters to deliver either N–H or N-Me indazoles in a controllable manner is reported. DFT calculations explain the regioselectivity and the mechanism.
A general and authoritative literature overview on Pd-catalyzed cross-dehydrogenative coupling reactions of (hetero)arenes from the origins to 2023, where not only the synthetic aspects were described but also the most relevant mechanistic features.
3-Carboxamide indazoles have been developed using the amide coupling process. Density function theory (DFT) computations, and the assessment of binding energy using Auto Dock, illustrate the pharmaceutical effectiveness.