An efficient strategy for constructing di/trifluoromethyl bis(1,2,4-triazoline)spiranes and 1,2,4-triazoles via a 1,3-dipolar cycloaddition reaction of nitrilimines and carbodiimides was developed.
A convenient synthesis of fused indolin-3-one derivatives via (3 + 2)-cycloaddition from readily available starting materials has been described.
Recent advances in the preparation of trifluoromethyl-containing heterocyclics via trifluoromethyl building block strategies over the period from 2019 to the present are systematically summarized and discussed.
A new reaction pattern of 5-allenyloxazolidine-2,4-diones was achieved under palladium catalysis.
We disclose a method for silver-enabled formal [4π + 2σ] cycloaddition reactions between bicyclobutanes and nitrile imines (generated from hydrazonyl chlorides) to furnish a diverse array of 2,3-diazo-BCHepes.