Two novel series of pyridazin-3-ones, designed as potential vasodilators, demonstrated superior aortic vasorelaxant activity, eNOS mRNA expression and nitric oxide up-levelling.
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
The current study reports the synthesis and photophysical characteristics of novel folded organic molecules connected by a four-atom spacer.
This study focused on design and synthesis of novel pyrazole-pyrrolinone and pyridazinone derivatives and evaluation of their antimicrobial, antibiofilm, and mechanistic properties to identify promising lead compounds.
Elaboration of an established ‘address system’ leads to a new series of small-molecule imaging probes specifically targeted to formyl peptide receptors (FPRs), to achieve direct cellular localisation and visualisation of receptor functions.