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Chemical approaches to explore ubiquitin-like proteins

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Efficient Chemical Synthesis of Multi-Monoubiquitylated and Diubiquitylated Histones by the α-Halogen Ketone-Mediated Strategy

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Chemical Synthesis of Ubiquitinated Proteins and Ubiquitin Probes for Biochemical and Functional Analysis

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Chemistry A European J, 2026, 32
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Chemical Diversification of Enzymatically Assembled Polyubiquitin Chains to Decipher the Ubiquitin Codes Programmed on the Branch Structure

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J. Am. Chem. Soc., 2024
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Examining the Role of Threonine Phosphorylation in Ubiquitin’s Function Using Chemical Protein Synthesis

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JACS Au, 2025, 5, 2148
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Temporary Structural Supports for Chemical Protein Synthesis

Yanbo Liu, Dongyang Han and Lei Liu

Angewandte Chemie, 2025, 137
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Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

Pauline Franz and Beat Fierz

Journal of Molecular Biology, 2024, 436, 168442
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Thioether-mediated protein ubiquitination in constructing affinity- and activity-based ubiquitinated protein probes

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Research Progress of Proteasome Inhibitor MG132 in Treatment of Gynecologic Malignant Tumors

Xiaoyang Liu, Zizhang Li, Chengguo Zhang, Jun Liang and Nan Zhou

J Biochem & Molecular Tox, 2026, 40
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Genetic Code Expansion Approaches to Decipher the Ubiquitin Code

Vera Wanka, Maximilian Fottner, Marko Cigler and Kathrin Lang

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Convergent Assembly of Homo‐ and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol‐Ene Chemistry

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Angew Chem Int Ed, 2025, 64
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Konvergenter Aufbau Homo‐ und Heterotypischer Ubiquitinketten aus funktionaliserten, exprimierten Monomeren mittels Thiol‐En‐Chemie

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Angewandte Chemie, 2025, 137
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SOD1, A Crucial Protein for Neural Biochemistry: Dysfunction and Risk of Amyotrophic Lateral Sclerosis

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Temporary Structural Supports for Chemical Protein Synthesis

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Histone modification cross-talk: analytical tools and molecular mechanisms

Jennifer Jiang, Sarah DuBois-Coyne, Eunju Nam, Samuel D. Whedon, Kwangwoon Lee and Philip A. Cole

Biochemical Journal, 2026, 483, 713
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Expedient Chemical Synthesis of Ufmylated Histones Using Chemoenzymatic C-Terminal Hydrazinolysis of Ubiquitin-Fold Modifier 1

Xin Liu, Cong Chen, Fang Li, Xiaotong Liu, Chengpiao Lu, Yuanpeng Li, Shuai Peng, Hongrui Xu, Changlin Tian, Guoqiang Xu and Jia-Bin Li

ACS Chem. Biol., 2026, 21, 1146
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Development of Substrate-Directed Activity-Based Probes via Disulfide-Trapping for Site-Specific Interrogation of Nucleosomal Deubiquitination

Zaozhen He, Yuantong Huo, Yanling Zhang, Shixian Tao, Yun Liu, Zhiheng Deng, Xiaolin Tian, Xinyu Lan, Haiteng Deng, Lei Liu, Wei Qin and Huasong Ai

J. Am. Chem. Soc., 2026, 148, 6485
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