Chemical diversification of polyprenyl quinones for mechanistic studies on menaquinone-binding peptide antibiotics

Eilidh J. Matheson, Roy A. M. van Beekveld, Paolo Innocenti, Nathaniel I. Martin, Markus Weingarth and Stephen A. Cochrane

Chem. Sci., 2025, 16, 13629
DOI: 10.1039/D5SC03363B

Synthesis and structure–activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine

Ross D. Ballantine, Karol Al Ayed, Samantha J. Bann, Michael Hoekstra, Nathaniel I. Martin and Stephen A. Cochrane

RSC Med. Chem., 2022, 13, 1640
DOI: 10.1039/D2MD00281G

A novel approach for the synthesis of the cyclic lipopeptide globomycin

Samantha J. Bann and Stephen A. Cochrane

RSC Med. Chem., 2025, 16, 373
DOI: 10.1039/D4MD00685B

Factors influencing on-resin depsipeptide bond formation: case studies on daptomycin- and brevicidine-derived sequences

Dennise Palpal-latoc, Margaret A. Brimble, Paul W. R. Harris and Aimee J. Horsfall

Org. Biomol. Chem., 2023, 21, 4052
DOI: 10.1039/D3OB00360D

Macrocyclization strategies for the total synthesis of cyclic depsipeptides

André R. Paquette and Christopher N. Boddy

Org. Biomol. Chem., 2023, 21, 8043
DOI: 10.1039/D3OB01229H

Studies on daptomycin lactam‐based analogues

Hoi Yee Chow, Kathy Hiu Laam Po, Sheng Chen and Xuechen Li

Journal of Peptide Science, 2022, 28
DOI: 10.1002/psc.3430

Allenamides as a Powerful Tool to Incorporate Diversity: Thia‐Michael Lipidation of Semisynthetic Peptides and Access to β‐Keto Amides

Tae‐Ung Na, Veronika Sander, Alan J. Davidson, Rolland Lin, Yann O. Hermant, Madeleine T. Hardie Boys, Daniel Pletzer, Georgia Campbell, Scott A. Ferguson, Gregory M. Cook, Jane R. Allison, Margaret A. Brimble, Brian H. Northrop and Alan J. Cameron

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202407764

Exploring Structure–Activity Relationships and Modes of Action of Laterocidine

Varsha J. Thombare, James D. Swarbrick, Mohammad A. K. Azad, Yan Zhu, Jing Lu, Heidi Y. Yu, Hasini Wickremasinghe, Xiaoji He, Mahimna Bandiatmakur, Rong Li, Phillip J. Bergen, Tony Velkov, Jiping Wang, Kade D. Roberts, Jian Li and Nitin A. Patil

ACS Cent. Sci., 2024, 10, 1703
DOI: 10.1021/acscentsci.4c00776

Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine

Xinghong Zhao, Xinyi Zhong, Shinong Yang, Kai Deng, Lu Liu, Xu Song, Yuanfeng Zou, Lixia Li, Xun Zhou, Renyong Jia, Juchun Lin, Huaqiao Tang, Gang Ye, Jianqing Yang, Shan Zhao, Yifei Lang, Hongping Wan, Zhongqiong Yin and Oscar P. Kuipers

Antimicrob Agents Chemother, 2023, 67
DOI: 10.1128/aac.00010-23

Biosynthesis of a novel antimicrobial brevicidine as potential food biopreservative from Brevibacillus laterosporus 811 and its anti-infection effect against Escherichia coli and Salmonella

Yonghang Ma, Sheng Huang, Guangxin Yang, Siyi Peng, Renli Qi, Bing Dong, Shiyan Qiao, Xiangfang Zeng and Haitao Yu

Food Bioscience, 2025, 69, 106937
DOI: 10.1016/j.fbio.2025.106937

Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability

Karol Al Ayed, Denise Zamarbide Losada, Nataliia V. Machushynets, Barbara Terlouw, Somayah S. Elsayed, Julian Schill, Vincent Trebosc, Michel Pieren, Marnix H. Medema, Gilles P. van Wezel and Nathaniel I. Martin

ACS Infect. Dis., 2023, 9, 739
DOI: 10.1021/acsinfecdis.3c00043

Towards further understanding the applications of endophytes: enriched source of bioactive compounds and bio factories for nanoparticles

Nisha Choudhary, Naveen Dhingra, Amel Gacem, Virendra Kumar Yadav, Rakesh Kumar Verma, Mahima Choudhary, Uma Bhardwaj, Rajendra Singh Chundawat, Mohammed S. Alqahtani, Rajarshi Kumar Gaur, Lienda Bashier Eltayeb, Waleed Al Abdulmonem and Byong-Hun Jeon

Front. Plant Sci., 2023, 14
DOI: 10.3389/fpls.2023.1193573

In-vitro evaluation of cationic Lipopeptides as adjuvant candidate for DNA plasmid vaccine

Syahrul Febrian Hasbullah, Ace Tatang Hidayat, Tarwadi, Adinda Nurhidayatul Fajri, Nurlelasari, Desi Harneti, Kindi Farabi, Unang Supratman and Rani Maharani

Bioorganic & Medicinal Chemistry Letters, 2025, 122, 130183
DOI: 10.1016/j.bmcl.2025.130183

Total Synthesis, Structure Elucidation, and Bioactivity Evaluation of the Cyclic Lipopeptide Natural Product Paenilipoheptin A

Vladyslav Lysenko, Nataliia V. Machushynets, Jisca L. van Dam, Fabienne A. C. Sterk, Alexander Speer, Arthur F. J. Ram, Cornelis J. Slingerland, Gilles P. Van Wezel and Nathaniel I. Martin

Org. Lett., 2025, 27, 2826
DOI: 10.1021/acs.orglett.5c00232

Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial Activity

Ross D. Ballantine, Karol Al Ayed, Samantha J. Bann, Michael Hoekstra, Nathaniel I. Martin and Stephen A. Cochrane

J. Med. Chem., 2023, 66, 6002
DOI: 10.1021/acs.jmedchem.3c00308

Characterization of a Novel Bacillus glycinifermentans Strain MGMM1 Based on Full Genome Analysis and Phenotypic Properties for Biotechnological Applications

Daniel Mawuena Afordoanyi, Roderic Gilles Claret Diabankana, Ernest Nailevich Komissarov, Evgenii Sergeyevich Kuchaev and Shamil Zavdatovich Validov

Microorganisms, 2023, 11, 1410
DOI: 10.3390/microorganisms11061410

Lipopeptides development in cosmetics and pharmaceutical applications: A comprehensive review

Melania Pilz, Philipp Cavelius, Farah Qoura, Dania Awad and Thomas Brück

Biotechnology Advances, 2023, 67, 108210
DOI: 10.1016/j.biotechadv.2023.108210

Allenamides as a Powerful Tool to Incorporate Diversity: Thia‐Michael Lipidation of Semisynthetic Peptides and Access to β‐Keto Amides

Tae‐Ung Na, Veronika Sander, Alan J. Davidson, Rolland Lin, Yann O. Hermant, Madeleine T. Hardie Boys, Daniel Pletzer, Georgia Campbell, Scott A. Ferguson, Gregory M. Cook, Jane R. Allison, Margaret A. Brimble, Brian H. Northrop and Alan J. Cameron

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202407764

Design and Production of Geranylated Cyclic Peptides by the RiPP Enzymes SyncM and PirF

Yanli Xu, Fleur Ruijne, Manel Garcia Diez, Jorrit Jilles Stada and Oscar P. Kuipers

Biomacromolecules, 2025, 26, 3186
DOI: 10.1021/acs.biomac.5c00260

Synthesis, Structure–Activity Relationship Study, Bioactivity, and Nephrotoxicity Evaluation of the Proposed Structure of the Cyclic Lipodepsipeptide Brevicidine B

Dennise Palpal-latoc, Aimee J. Horsfall, Alan J. Cameron, Georgia Campbell, Scott A. Ferguson, Gregory M. Cook, Veronika Sander, Alan J. Davidson, Paul W. R. Harris and Margaret A. Brimble

J. Nat. Prod., 2024, 87, 764
DOI: 10.1021/acs.jnatprod.3c00876

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao and Simone Kosol

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202414325

Semiautomated Total Synthesis of the Cyclic Lipodepsipeptide Anikasin

Yuko Bando, Martin Klapper, Rosa Herbst, Anna Sachse, Pierre Stallforth and Hans-Dieter Arndt

Org. Lett., 2025, 27, 2559
DOI: 10.1021/acs.orglett.5c00111

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao and Simone Kosol

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202414325

Polymyxin Stereochemistry and Its Role in Antibacterial Activity and Outer Membrane Disruption

Cornelis J. Slingerland, Ioli Kotsogianni, Charlotte M. J. Wesseling and Nathaniel I. Martin

ACS Infect. Dis., 2022, 8, 2396
DOI: 10.1021/acsinfecdis.2c00307

The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry

Søren Lau Borcher Møller, Michelle H. Rasmussen, Jun Li, Esben B. Svenningsen, Gustav J. Wørmer, Thomas Tørring and Thomas B. Poulsen

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400013

Total Synthesis and Structural Reassignment of the Antitubercular Natural Product Evybactin

Vladyslav Lysenko, Sangkeun Son, Monique E. Theriault, Cornelis J. Slingerland, Glenn Hauk, Laurence Cleenewerk, Alexander Speer, James M. Berger, Kim Lewis and Nathaniel I. Martin

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202403767