Recent advances in mixing-induced nanoprecipitation: from creating complex nanostructures to emerging applications beyond biomedicine

Tianyou Chen, Yan Peng, Meishuang Qiu, Changfeng Yi and Zushun Xu

Nanoscale, 2023, 15, 3594
DOI: 10.1039/D3NR00280B

Formulation, characterization, and In vitro evaluation of lenvatinib-loaded solid lipid nanoparticles functionalized with Twenty-Polyglycerol vitamin E succinate for liver cancer treatment

Yanyan Zhou, Shengnan Luo, Zhe Jiang, Xiang Luo, Zhangsen Yu, Zhixin Wang and Kewu Zhu

Drug Development and Industrial Pharmacy, 2025, 51, 1528
DOI: 10.1080/03639045.2025.2542473

Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance

Yumin Wang, Yongming Chen, Junjing Zhang, Yihui Yang, Joshua S. Fleishman, Yan Wang, Jinhua Wang, Jichao Chen, Yuanfang Li and Hongquan Wang

Drug Resistance Updates, 2024, 72, 101018
DOI: 10.1016/j.drup.2023.101018

Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities

Ziling Pang

Front. Mol. Biosci., 2025, 12
DOI: 10.3389/fmolb.2025.1578693

Photothermal therapy of copper incorporated nanomaterials for biomedicine

Rong Wang, Ziwei Huang, Yunxiao Xiao, Tao Huang and Jie Ming

Biomater Res, 2023, 27
DOI: 10.1186/s40824-023-00461-z

Lenvatinib resistance mechanism and potential ways to conquer

Wentao Bo and Yan Chen

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1153991

A multifunctional nanoplatform based on chlorin e6 for fluorescence imaging-guided sonodynamic and chemodynamic cancer therapy

Qi Xu, Fang He, Zhimin Mo, Han Hu, Qianyuan He, Zushun Xu, Shengli Yang and Xiaojuan Qin

Colloids and Surfaces B: Biointerfaces, 2025, 253, 114718
DOI: 10.1016/j.colsurfb.2025.114718

New insights into the mechanism of resistance to lenvatinib and strategies for lenvatinib sensitization in hepatocellular carcinoma

Fei-Mu Fan, Joshua S. Fleishman, Jin Chen, Zhe-Sheng Chen and Han-Hua Dong

Drug Discovery Today, 2024, 29, 104069
DOI: 10.1016/j.drudis.2024.104069

Lenvatinib and immune-checkpoint inhibitors in hepatocellular carcinoma: mechanistic insights, clinical efficacy, and future perspectives

Yuhang Chen, Suoyi Dai, Chien-shan Cheng and Lianyu Chen

J Hematol Oncol, 2024, 17
DOI: 10.1186/s13045-024-01647-1

Recent advances in copper sulfide nanoparticles for cancer diagnosis and therapy

Guangyao Li, Xiang Li, Zhangrong Lou, Junnan Xu, Yiwen Ma, Xiaorui Li, Qiang Liu and Tao Sun

Materials Today Bio, 2025, 34, 102197
DOI: 10.1016/j.mtbio.2025.102197

A multifunctional nanotheranostic agent based on Lenvatinib for multimodal synergistic hepatocellular carcinoma therapy with remarkably enhanced efficacy

Qi Xu, Han Hu, Zhimin Mo, Tianyou Chen, Qianyuan He and Zushun Xu

Journal of Colloid and Interface Science, 2023, 638, 375
DOI: 10.1016/j.jcis.2023.01.144

Homologous cancer cell membrane-camouflaged nanoparticles target drug delivery and enhance the chemotherapy efficacy of hepatocellular carcinoma

Yahui Wu, Rongtao Zhu, Mengyang Zhou, Jingjing Liu, Kai Dong, Senfeng Zhao, Jiahui Cao, Weijie Wang, Chenguang Sun, Shitao Wu, Fan Wang, Yupeng Shi and Yuling Sun

Cancer Letters, 2023, 558, 216106
DOI: 10.1016/j.canlet.2023.216106

Cuproplasia and cuproptosis in hepatocellular carcinoma: mechanisms, relationship and potential role in tumor microenvironment and treatment

Ruoyu Zhang, Yunfei Tan, Ke Xu, Ning Huang, Jian Wang, Mei Liu and Liming Wang

Cancer Cell Int, 2025, 25
DOI: 10.1186/s12935-025-03683-4

Nanocarrier-Based Delivery of Arsenic Trioxide for Hepatocellular Carcinoma Therapy

Jiang Sun, Mengying Cheng, Tingxian Ye, Bin Li, Yinghui Wei, Hangsheng Zheng, Hongyue Zheng, Meiqi Zhou, Ji-Gang Piao and Fanzhu Li

Nanomedicine (Lond.), 2022, 17, 2037
DOI: 10.2217/nnm-2022-0250

Chitosan-based nanoscale delivery systems in hepatocellular carcinoma: Versatile bio-platform with theranostic application

Kimia Karimi, Sarah Mojtabavi, Pooya M. Tehrany, Melina Maghsodlou Nejad, Aryan Rezaee, Shahab Mohtashamian, Erfan Hamedi, Farnaz Yousefi, Farshid Salmani, Mohammad Arad Zandieh, Noushin Nabavi, Navid Rabiee, Yavuz Nuri Ertas, Shokooh Salimimoghadam, Mohsen Rashidi, Parham Rahmanian, Kiavash Hushmandi and Wei Yu

International Journal of Biological Macromolecules, 2023, 242, 124935
DOI: 10.1016/j.ijbiomac.2023.124935

Strategies and Recent Advances on Improving Efficient Antitumor of Lenvatinib Based on Nanoparticle Delivery System

Haiqing Wang, Wentao Bo, Xielin Feng, Jinliang Zhang, Ge Li and Yan Chen

IJN, 2024, Volume 19, 5581
DOI: 10.2147/IJN.S460844

BSA-coated β-FeOOH nanoparticles efficiently deliver the photosensitizer chlorin e6 for synergistic anticancer PDT/CDT

Han Hu, Ruiqi Li, Piao Huang, Zhimin Mo, Qi Xu, Tao Hu, Shijie Yao, Xiaofang Dai and Zushun Xu

Colloids and Surfaces B: Biointerfaces, 2023, 222, 113117
DOI: 10.1016/j.colsurfb.2022.113117

Insights into lenvatinib resistance: mechanisms, potential biomarkers, and strategies to enhance sensitivity

Qiang You, Rong Li, Jia Yao, Ying-Cai Zhang, Xin Sui, Cui-Cui Xiao, Jie-Bin Zhang, Jia-Qi Xiao, Hai-Tian Chen, Hua Li, Jian Zhang, Jun Zheng and Yang Yang

Med Oncol, 2024, 41
DOI: 10.1007/s12032-023-02295-0

Dual-responsive magnetic vortex nanorings co-deliver lenvatinib and localized heat for synergistic activation of antitumor immunity

Zirui Ye, Bin Yan, Hugang Li, Qianqian Tang, Kexin Yuan, Jingjing Hou, Lexuan Xu, Jianlan Yuan, Siyao Wang, Wangbo Jiao, Haiming Fan, Yi Lyu, Bo Wang and Xiaoli Liu

Acta Biomaterialia, 2025, 198, 389
DOI: 10.1016/j.actbio.2025.04.014