Isothiourea catalysed enantioselective generation of point and axially chiral iminothia- and iminoselenazinanones

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Chem. Sci., 2025, 16, 10494
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Organocatalytic asymmetric synthesis of benzothiazolopyrimidines via a [4 + 2] cycloaddition of azlactones with 2-benzothiazolimines

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Rice straw ash extract/glycerol: an efficient sustainable approach for Knoevenagel condensation

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New J. Chem., 2022, 46, 4570
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Isothiourea-catalyzed formal enantioselective conjugate addition of benzophenone imines to β-fluorinated α,β-unsaturated esters

Jerson E. Lapetaje, Claire M. Young, Chang Shu and Andrew D. Smith

Chem. Commun., 2022, 58, 6886
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Isothiourea-catalysed enantioselective radical conjugate addition under batch and flow conditions

Roberto del Río-Rodríguez, Matthew T. Westwood, Marina Sicignano, Martin Juhl, Jose A. Fernández-Salas, José Alemán and Andrew D. Smith

Chem. Commun., 2022, 58, 7277
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Enantiopure isothiourea@carbon-based support: stacking interactions for recycling a lewis base in asymmetric catalysis

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Understanding divergent substrate stereoselectivity in the isothiourea-catalysed conjugate addition of cyclic α-substituted β-ketoesters to α,β-unsaturated aryl esters

Ding Yuan, Alister S. Goodfellow, Kevin Kasten, Zhuan Duan, Tengfei Kang, David B. Cordes, Aidan P. McKay, Michael Bühl, Gregory R. Boyce and Andrew D. Smith

Chem. Sci., 2023, 14, 14146
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Asymmetric isochalcogenourea-catalysed (4 + 2)-cycloadditions of ortho-quinone methides and allenoates

Anna Scheucher, Christoph Gross, Magdalena Piringer, Johanna Novacek, Armin R. Ofial and Mario Waser

Org. Biomol. Chem., 2025, 23, 827
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De-epimerizing DyKAT of β-lactones generated by isothiourea-catalysed enantioselective [2 + 2] cycloaddition

Aífe Conboy, Alister S. Goodfellow, Kevin Kasten, Joanne Dunne, David B. Cordes, Michael Bühl and Andrew D. Smith

Chem. Sci., 2024, 15, 8896
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Cooperative catalysis of carbenes and Lewis acids for the highly enantioselective synthesis of dihydroquinolones via in situ generation of aza-ortho-quinone methide and enolate intermediates

Zhiying Li, Zhenhong Wu, Huan Gong, Xinyi Xu, Jianfeng Xu and Xingkuan Chen

Org. Chem. Front., 2024, 11, 1713
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Multicomponent Enantioselective Synthesis of Tetrahydropyridazinones Employing Chiral α,β-Unsaturated Acylammonium Salts

Sigrid A. Kiledal, Roxane Jourdain, Sreekumar Vellalath and Daniel Romo

Org. Lett., 2021, 23, 6622
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Modular Access to Fluorinated Quaternary Stereocenters via Palladium/Lewis Base Synergistic Catalysis

Rixin Liu, Qinglong Zhang, Zitong Lin, Thomas N. Snaddon and Weiwei Zi

Angewandte Chemie, 2025, 137
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Organocatalytic Asymmetric (3+3) Cycloaddition of 4‐Hydroxycoumarins with α,β‐Unsaturated Aryl Esters

Hao Chen, Shuang Yang, Ning‐Yi Wang, Ya‐Ping Tian, Yu‐Chen Zhang and Feng Shi

ChemCatChem, 2025, 17
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Stereoselective Michael Additions of Arylacetic Acid Derivatives by Asymmetric Organocatalysis

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Synlett, 2022, 33, 609
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Lewis Base‐Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones

Will C. Hartley, Florian Schiel, Elena Ermini and Paolo Melchiorre

Angewandte Chemie, 2022, 134
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Isochalcogenourea-catalyzed asymmetric (4 + 2)-heterocycloadditions of allenoates

Mario Waser

Chemistry Letters, 2024, 53
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Cooperative Chiral Lewis Base/Palladium‐Catalyzed Asymmetric Syntheses of Methylene‐Containing δ‐Lactams

Paul Zebrowski, Uwe Monkowius and Mario Waser

Eur J Org Chem, 2023, 26
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Isothiourea‐Catalysed Acylative Kinetic Resolution of Tertiary Pyrazolone Alcohols

Matthew T. Westwood, Abdikani Omar Farah, Henry B. Wise, Mike Sinfield, Camille Robichon, Martha I. Prindl, David B. Cordes, Paul Ha‐Yeong Cheong and Andrew D. Smith

Angewandte Chemie, 2024, 136
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Control Over S(VI) Stereogenicity for the Asymmetric Synthesis of Sulfonimidoyl Derivatives by Isothiourea‐Catalyzed Covalent Activation of Sulfur(VI) Atoms

Benpeng Li, Junyuan Hu, Zhengtao Xu, Minghong Liao, Yonggui Robin Chi and Xingxing Wu

Angew Chem Int Ed, 2025, 64
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Synthesis of Benzo[4,5]Thiazolo[3,2‐a]Pyridine Derivatives via NHC‐Catalyzed [3+3] Annulation of δ‐Acetoxy Allenoates

Yu Zhang, Yuliang Gan, Chenxia Yu, Kai Zhang and Changsheng Yao

ChemistrySelect, 2026, 11
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Chiral Lewis Base‐Catalysed Asymmetric Syntheses of Benzo‐fused ϵ‐Lactones

Lotte Stockhammer, Maximilian Radetzky, Syeda Sadia Khatoon, Matthias Bechmann and Mario Waser

Eur J Org Chem, 2023, 26
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Enantioselective Syntheses of 3,4‐Dihydropyrans Employing Isochalcogenourea‐Catalyzed Formal (4+2)‐Cycloadditions of Allenoates

Magdalena Piringer, Mario Hofer, Lukas S. Vogl, Peter Mayer and Mario Waser

Adv Synth Catal, 2024, 366, 2115
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Enantioselective Synthesis in Continuous Flow: Polymer-Supported Isothiourea-Catalyzed Enantioselective Michael Addition–Cyclization with α-Azol-2-ylacetophenones

Zhanyu Zhou, Kevin Kasten, Tengfei Kang, David B. Cordes and Andrew D. Smith

Org. Process Res. Dev., 2024, 28, 2041
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Isothiourea‐Catalyzed Enantioselective Functionalisation of Glycine Schiff Base Aryl Esters via 1,6‐ and 1,4‐Additions

Lotte Stockhammer, Rebecca Craik, Uwe Monkowius, David B. Cordes, Andrew D. Smith and Mario Waser

ChemistryEurope, 2023, 1
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Synthesis of Tetra‐Substituted 3‐Hydroxyphthalide Esters by Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution

Shubham K. Agrawal, Pankaj K. Majhi, Alister S. Goodfellow, Raj K. Tak, David B. Cordes, Aidan P. McKay, Kevin Kasten, Michael Bühl and Andrew D. Smith

Angewandte Chemie, 2024, 136
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Asymmetric Organocatalyzed Intermolecular Functionalization of Cyclohexanone‐Derived Dienones

Corinne Coutant, Paul De Bonfils, Pierrick Nun and Vincent Coeffard

The Chemical Record, 2023, 23
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Base-Promoted Aminoamidation of Cinnamoyl Chlorides with Aryl Amines: Access to β-Amino Amides

Yongpeng Zheng, Jianxiao Li, Chaorong Qi, Wanqing Wu and Huanfeng Jiang

J. Org. Chem., 2024, 89, 15289
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Organocatalytic Enantio‐ and Diastereoselective Diels‐Alder Reaction between 2,4‐Dienals and α,β‐Unsaturated Esters

Byungjun Kim, Sukwoo Lee and Sarah Yunmi Lee

Adv Synth Catal, 2023, 365, 3887
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Achiral Cp*Rh(III)/Chiral Lewis Base Cooperative Catalysis for Enantioselective Cyclization via C–H Activation

Takumaru Kurihara, Masahiro Kojima, Tatsuhiko Yoshino and Shigeki Matsunaga

J. Am. Chem. Soc., 2022, 144, 7058
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Chiral Isochalcogenourea‐Catalysed Enantioselective (4+2) Cycloadditions of Allenoates

Lukas S. Vogl, Peter Mayer, Raphaël Robiette and Mario Waser

Angew Chem Int Ed, 2024, 63
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Isoselenourea‐Catalyzed Enantioselective Pyrazolo‐Heterocycle Synthesis Enabled by Self‐Correcting Amide and Ester Acylation

Martha I. Prindl, Matthew T. Westwood, Alister S. Goodfellow, Aidan P. McKay, David B. Cordes, Michael Bühl and Andrew D. Smith

Angewandte Chemie, 2025, 137
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From Oxygen to Tellurium: The Impact of the Chalcogen on Nucleophilicities and Basicities of Isochalcogenourea Catalysts

Lotte Stockhammer, Kevin Kasten, Andreas Eitzinger, Lukas S. Vogl, Magdalena Piringer, David Weinzierl, Armin R. Ofial, Andrew D. Smith and Mario Waser

Angew Chem Int Ed, 2025, 64
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Mechanistic studies on an isothiourea-catalyzed reaction of an aromatic ester with an imine

Meng-Qing Yang and Yang Wang

Molecular Catalysis, 2024, 567, 114445
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Cooperative Palladium/Isothiourea Catalyzed Enantioselective Formal (3+2) Cycloaddition of Vinylcyclopropanes and α,β‐Unsaturated Esters

Jacqueline Bitai, Alastair J. Nimmo, Alexandra M. Z. Slawin and Andrew D. Smith

Angewandte Chemie, 2022, 134
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Chiral Isochalcogenourea‐Catalysed Enantioselective (4+2) Cycloadditions of Allenoates

Lukas S. Vogl, Peter Mayer, Raphaël Robiette and Mario Waser

Angewandte Chemie, 2024, 136
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Organocatalyzed Asymmetric Synthesis of Thiacycles

Anup Biswas

Asian J Org Chem, 2025, 14
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Organophosphites: An Addition to the Arsenal of Organocatalysts

Nilofar Baral, Soniya Rani, Pinku Saikia and Pradip Maity

Eur J Org Chem, 2023, 26
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Synthesis of Tetra‐Substituted 3‐Hydroxyphthalide Esters by Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution

Shubham K. Agrawal, Pankaj K. Majhi, Alister S. Goodfellow, Raj K. Tak, David B. Cordes, Aidan P. McKay, Kevin Kasten, Michael Bühl and Andrew D. Smith

Angew Chem Int Ed, 2024, 63
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Isothiourea-Catalyzed Enantioselective Michael Addition of Malonates to α,β-Unsaturated Aryl Esters

Jiufeng Wu, Claire M. Young, Amy A. Watts, Alexandra M. Z. Slawin, Gregory R. Boyce, Michael Bühl and Andrew D. Smith

Org. Lett., 2022, 24, 4040
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Isothiourea-Catalyzed Enantioselective Synthesis of trans-3,4-Dihydrothiopyranones: Harnessing Thiochalcones as Original Michael Acceptors

Damien Bouchet, Elsa Van Elslande and Géraldine Masson

Org. Lett., 2023, 25, 5395
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Isothiourea‐Catalysed Acylative Kinetic Resolution of Tertiary Pyrazolone Alcohols

Matthew T. Westwood, Abdikani Omar Farah, Henry B. Wise, Mike Sinfield, Camille Robichon, Martha I. Prindl, David B. Cordes, Paul Ha‐Yeong Cheong and Andrew D. Smith

Angew Chem Int Ed, 2024, 63
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Lewis Base‐Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones

Will C. Hartley, Florian Schiel, Elena Ermini and Paolo Melchiorre

Angew Chem Int Ed, 2022, 61
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Determination of the pKaH of Established Isothiourea Catalysts

Lukas S. Vogl, Matthias Bechmann and Mario Waser

Eur J Org Chem, 2025, 28
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Modular Access to Fluorinated Quaternary Stereocenters via Palladium/Lewis Base Synergistic Catalysis

Rixin Liu, Qinglong Zhang, Zitong Lin, Thomas N. Snaddon and Weiwei Zi

Angew Chem Int Ed, 2025, 64
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Control Over S(VI) Stereogenicity for the Asymmetric Synthesis of Sulfonimidoyl Derivatives by Isothiourea‐Catalyzed Covalent Activation of Sulfur(VI) Atoms

Benpeng Li, Junyuan Hu, Zhengtao Xu, Minghong Liao, Yonggui Robin Chi and Xingxing Wu

Angewandte Chemie, 2025, 137
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Catalyst‐free Synthesis of Benzothiazolopyrimidines via Visible‐Light‐Induced Wolff Rearrangement/[4+2] Cycloaddition Process

Jiao‐Mei Wang, Yang‐Xu Chen, Chang‐Sheng Yao and Kai Zhang

Asian J Org Chem, 2022, 11
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Enantioselective α-heterofunctionalization reactions of catalytically generated C1-Lewis base enolates

Magdalena Piringer, Lotte Stockhammer, Lukas Vogl, David Weinzierl, Paul Zebrowski and Mario Waser

Tetrahedron Chem, 2024, 9, 100063
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Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution of Tetra‐substituted Morpholinone and Benzoxazinone Lactols

Haoxiang Zhu, Alejandro Manchado, Abdikani Omar Farah, Aidan P. McKay, David B. Cordes, Paul Ha‐Yeon Cheong, Kevin Kasten and Andrew D. Smith

Angewandte Chemie, 2024, 136
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Rhodium and Isothiourea Dual Catalysis: Enantiodivergent Transformation of Terminal Alkynes

Tao Fan, Zhipeng Shi, Qian-Wei Gong, Jin Song and Liu-Zhu Gong

Org. Lett., 2024, 26, 1421
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Isothiourea‐Catalysed Acylative Dynamic Kinetic Resolution of Tetra‐substituted Morpholinone and Benzoxazinone Lactols

Haoxiang Zhu, Alejandro Manchado, Abdikani Omar Farah, Aidan P. McKay, David B. Cordes, Paul Ha‐Yeon Cheong, Kevin Kasten and Andrew D. Smith

Angew Chem Int Ed, 2024, 63
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Isoselenourea‐Catalyzed Enantioselective Pyrazolo‐Heterocycle Synthesis Enabled by Self‐Correcting Amide and Ester Acylation

Martha I. Prindl, Matthew T. Westwood, Alister S. Goodfellow, Aidan P. McKay, David B. Cordes, Michael Bühl and Andrew D. Smith

Angew Chem Int Ed, 2025, 64
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Cooperative Palladium/Isothiourea Catalyzed Enantioselective Formal (3+2) Cycloaddition of Vinylcyclopropanes and α,β‐Unsaturated Esters

Jacqueline Bitai, Alastair J. Nimmo, Alexandra M. Z. Slawin and Andrew D. Smith

Angew Chem Int Ed, 2022, 61
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Radical Reactions with Chiral Acylammonium Salts: Synthesis of Functionalized δ-Lactams through Giese-Initiated Organocascades

Patrick J. Sutter, Ben Walker, Kristiana Kasper, Volga Kojasoy, Dean J. Tantillo and Daniel Romo

J. Org. Chem., 2024, 89, 14209
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Enantioselective isothiourea-catalysed α-fluorination of C1-ammonium enolates generated from arylesters

Nicole Stanek, Lotte Stockhammer, Anja Moser and Mario Waser

Journal of Fluorine Chemistry, 2025, 283-284, 110434
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Von Sauerstoff zu Tellur: Der Einfluss des Chalkogenatoms auf die Nucleophilie und Basizität von Isochalkogenharnstoff‐basierten Katalysatoren

Lotte Stockhammer, Kevin Kasten, Andreas Eitzinger, Lukas S. Vogl, Magdalena Piringer, David Weinzierl, Armin R. Ofial, Andrew D. Smith and Mario Waser

Angewandte Chemie, 2025, 137
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Introducing TeHyperBTM as an Organocatalyst for (4 + 2)‐Cycloadditions of Michael Acceptors with Allenoates, But‐2‐ynoates or Allenylphosphonates

Magdalena Piringer, Anna Scheucher, Mario Hofer, Matthias Bechmann, Armin R. Ofial, Lotte Stockhammer and Mario Waser

ChemistryEurope, 2026, 4
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