Study of the interaction of folic acid-modified gold nanorods and fibrinogen through microfluidics: implications for protein adsorption, incorporation and viability of cancer cells

Nacaroha Orellana, Sujey Palma, Estefania Torres, María Luisa Cordero, Valentina Vio, Juan M. Ruso, Josué Juárez, Antonio Topete, Eyleen Araya, Rodrigo Vasquez-Contreras, Marcelo J. Kogan and Natalia Hassan

Nanoscale, 2021, 13, 17807
DOI: 10.1039/D1NR03179A

Nanoparticle-protein corona enhances accuracy of Ca-19.9-based pancreatic cancer classification

Luca Digiacomo, Damiano Caputo, Roberto Cammarata, Vincenzo La Vaccara, Roberto Coppola, Erica Quagliarini, Manuela Iacobini, Serena Renzi, Francesca Giulimondi, Daniela Pozzi, Giulio Caracciolo and Heinz Amenitsch

Nanoscale, 2025, 17, 7066
DOI: 10.1039/D4NR02435D

The role of coating layers in gold nanorods' radioenhancement: a Monte Carlo analysis

Taheri A., Khandaker M. U., Rabus H., Moradi F. and Bradley D. A.

Nanoscale Adv., 2025, 7, 3293
DOI: 10.1039/D5NA00220F

The protein corona reduces the anticancer effect of graphene oxide in HER-2-positive cancer cells

Lishan Cui, Erica Quagliarini, Siyao Xiao, Francesca Giulimondi, Serena Renzi, Luca Digiacomo, Giulio Caracciolo, Junbiao Wang, Augusto Amici, Cristina Marchini and Daniela Pozzi

Nanoscale Adv., 2022, 4, 4009
DOI: 10.1039/D2NA00308B

Converting the personalized biomolecular corona of graphene oxide nanoflakes into a high-throughput diagnostic test for early cancer detection

Massimiliano Papi, Valentina Palmieri, Luca Digiacomo, Francesca Giulimondi, Sara Palchetti, Gabriele Ciasca, Giordano Perini, Damiano Caputo, Maria Cristina Cartillone, Chiara Cascone, Roberto Coppola, Anna Laura Capriotti, Aldo Laganà, Daniela Pozzi and Giulio Caracciolo

Nanoscale, 2019, 11, 15339
DOI: 10.1039/C9NR01413F

Nanoparticle protein corona evolution: from biological impact to biomarker discovery

Nazila Kamaly, Omid C. Farokhzad and Claudia Corbo

Nanoscale, 2022, 14, 1606
DOI: 10.1039/D1NR06580G

Tuning the immune system by nanoparticle–biomolecular corona

Valentina Palmieri and Giulio Caracciolo

Nanoscale Adv., 2022, 4, 3300
DOI: 10.1039/D2NA00290F

Significance and implications of nanoparticle–biological corona fingerprints in diagnosis, prognosis, and therapeutics for diverse disorders

Jiayu Ren, Shupin Zhang and Sijin Liu

Nanoscale, 2023, 15, 11422
DOI: 10.1039/D3NR01768K

In vitroandex vivonano-enabled immunomodulation by the protein corona

Francesca Giulimondi, Luca Digiacomo, Elisabetta Vulpis, Luisa Loconte, Gianmarco Ferri, Francesco Cardarelli, Daniela Pozzi, Alessandra Zingoni and Giulio Caracciolo

Nanoscale, 2022, 14, 10531
DOI: 10.1039/D2NR01878K

Optimal centrifugal isolating of liposome–protein complexes from human plasma

Luca Digiacomo, Francesca Giulimondi, Anna Laura Capriotti, Susy Piovesana, Carmela Maria Montone, Riccardo Zenezini Chiozzi, Aldo Laganà, Morteza Mahmoudi, Daniela Pozzi and Giulio Caracciolo

Nanoscale Adv., 2021, 3, 3824
DOI: 10.1039/D1NA00211B

Personalized Graphene Oxide-Protein Corona in the Human Plasma of Pancreatic Cancer Patients

Riccardo Di Santo, Luca Digiacomo, Erica Quagliarini, Anna Laura Capriotti, Aldo Laganà, Riccardo Zenezini Chiozzi, Damiano Caputo, Chiara Cascone, Roberto Coppola, Daniela Pozzi and Giulio Caracciolo

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00491

Homogeneous Model for the Nanoparticle Growth in Polymer Matrices

Alexander Pikulin and Nikita Bityurin

J. Phys. Chem. C, 2020, 124, 16136
DOI: 10.1021/acs.jpcc.0c01249

The Fate of Nanoparticles In Vivo and the Strategy of Designing Stealth Nanoparticle for Drug Delivery

Jianwei Bao, Qianqian Zhang, Tijie Duan, Rongfeng Hu and Jihui Tang

CDT, 2021, 22, 922
DOI: 10.2174/1389450122666210118105122

Plasma proteins facilitates placental transfer of polystyrene particles

Michael M. Gruber, Birgit Hirschmugl, Natascha Berger, Magdalena Holter, Snježana Radulović, Gerd Leitinger, Laura Liesinger, Andrea Berghold, Eva Roblegg, Ruth Birner-Gruenberger, Vesna Bjelic-Radisic and Christian Wadsack

J Nanobiotechnol, 2020, 18
DOI: 10.1186/s12951-020-00676-5

On‐Chip Electrical Monitoring of Real‐Time “Soft” and “Hard” Protein Corona Formation on Carbon Nanoparticles

Indrajit Srivastava, Muhammad S. Khan, Ketan Dighe, Maha Alafeef, Zhen Wang, Tuseeta Banerjee, Tanmay Ghonge, Lauren M. Grove, Rashid Bashir and Dipanjan Pan

Small Methods, 2020, 4
DOI: 10.1002/smtd.202000099

Formation and biological effects of protein corona for food‐related nanoparticles

Guoxin Cui, Wentao Su and Mingqian Tan

Comp Rev Food Sci Food Safe, 2022, 21, 2002
DOI: 10.1111/1541-4337.12838

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

Rui Vitorino, Sofia Guedes, João Pinto da Costa and Václav Kašička

Nanomaterials, 2021, 11, 1118
DOI: 10.3390/nano11051118

Protein Corona Attenuates the Targeting of Antitumor Sialyl Lewis X-Decorated Liposomes to Vascular Endothelial Cells under Flow Conditions

Natalia R. Onishchenko, Alexey A. Moskovtsev, Maria K. Kobanenko, Daria S. Tretiakova, Anna S. Alekseeva, Dmitry V. Kolesov, Anna A. Mikryukova, Ivan A. Boldyrev, Marina R. Kapkaeva, Olga N. Shcheglovitova, Nicolai V. Bovin, Aslan A. Kubatiev, Olga V. Tikhonova and Elena L. Vodovozova

Pharmaceutics, 2023, 15, 1754
DOI: 10.3390/pharmaceutics15061754

Nanotechnology Meets Oncology: A Perspective on the Role of the Personalized Nanoparticle-Protein Corona in the Development of Technologies for Pancreatic Cancer Detection

Damiano Caputo, Erica Quagliarini, Daniela Pozzi and Giulio Caracciolo

IJMS, 2022, 23, 10591
DOI: 10.3390/ijms231810591

How Corona Formation Impacts Nanomaterials as Drug Carriers

Munishwar Nath Gupta and Ipsita Roy

Mol. Pharmaceutics, 2020, 17, 725
DOI: 10.1021/acs.molpharmaceut.9b01111

Charge-driven corona formation and nanoparticle cellular uptake: A microfluidic study on nanoparticle-protein interactions

Fangyuan Guo, Qinan Lv, Jinhong Zhao, Jing Wang, Jialin Chen, Nan Yu, Weiyong Hong, Yuping Lu and Gensheng Yang

Colloids and Surfaces B: Biointerfaces, 2025, 255, 114969
DOI: 10.1016/j.colsurfb.2025.114969

Protein‐DNA Competition at the Bio‐Nano Interface: Structural and Biological Insights From Graphene Oxide Coronas

Erica Quagliarini, Francesca Giulimondi, Serena Renzi, Andrea Pirrottina, Alessandra Zingoni, Nicholas Carboni, Daniela Pozzi and Giulio Caracciolo

Adv Materials Inter, 2025, 12
DOI: 10.1002/admi.202400560

Does the surface charge of the nanoparticles drive nanoparticle–cell membrane interactions?

Sandor Balog, Mauro Sousa de Almeida, Patricia Taladriz-Blanco, Barbara Rothen-Rutishauser and Alke Petri-Fink

Current Opinion in Biotechnology, 2024, 87, 103128
DOI: 10.1016/j.copbio.2024.103128

Synergistic Analysis of Protein Corona and Haemoglobin Levels Detects Pancreatic Cancer

Damiano Caputo, Luca Digiacomo, Chiara Cascone, Daniela Pozzi, Sara Palchetti, Riccardo Di Santo, Erica Quagliarini, Roberto Coppola, Morteza Mahmoudi and Giulio Caracciolo

Cancers, 2020, 13, 93
DOI: 10.3390/cancers13010093

Impact of the protein corona on nanomaterial immune response and targeting ability

Luca Digiacomo, Daniela Pozzi, Sara Palchetti, Alessandra Zingoni and Giulio Caracciolo

WIREs Nanomed Nanobiotechnol, 2020, 12
DOI: 10.1002/wnan.1615

Microfluidic synthesis as a new route to produce novel functional materials

Xinying Xie, Yisu Wang, Sin-Yung Siu, Chiu-Wing Chan, Yujiao Zhu, Xuming Zhang, Jun Ge and Kangning Ren

Biomicrofluidics, 2022, 16
DOI: 10.1063/5.0100206

Metered reagent injection into microfluidic continuous flow sampling for conductimetric ocean dissolved inorganic carbon sensing

Mark Tweedie, Antonin Macquart, Joao Almeida, Brian Ward and Paul Maguire

Meas. Sci. Technol., 2020, 31, 065104
DOI: 10.1088/1361-6501/ab7405

The influence of protein corona on liposomal delivery systems: A comprehensive review

Solmaz Mojarad-Jabali, Yousef Fatahi and Rassoul Dinarvand

European Journal of Pharmaceutical Sciences, 2025, 212, 107166
DOI: 10.1016/j.ejps.2025.107166

Splenic B cell-targeting lipid nanoparticles for safe and effective mRNA vaccine delivery

Yuichi Suzuki, Mai Yakuwa, Mina Sato, Eleni Samaridou, Moritz Beck-Broichsitter, Masatoshi Maeki, Manabu Tokeshi, Yuma Yamada, Hideyoshi Harashima and Yusuke Sato

Journal of Controlled Release, 2025, 382, 113687
DOI: 10.1016/j.jconrel.2025.113687

Scratching the Surface of the Protein Corona: Challenging Measurements and Controversies

Pierre-Luc Latreille, Marine Le Goas, Sina Salimi, Jordan Robert, Gregory De Crescenzo, Daria C. Boffito, Vincent A. Martinez, Patrice Hildgen and Xavier Banquy

ACS Nano, 2022, 16, 1689
DOI: 10.1021/acsnano.1c05901

(In)stability of ligands at the surface of inorganic nanoparticles: A forgotten question in nanomedicine?

Marine Le Goas, Justine Saber, Sara González Bolívar, Jean-Michel Rabanel, Jean-Marc Awogni, Daria C. Boffito and Xavier Banquy

Nano Today, 2022, 45, 101516
DOI: 10.1016/j.nantod.2022.101516

Stratifying Risk for Pancreatic Cancer by Multiplexed Blood Test

Luca Digiacomo, Erica Quagliarini, Daniela Pozzi, Roberto Coppola, Giulio Caracciolo and Damiano Caputo

Cancers, 2023, 15, 2983
DOI: 10.3390/cancers15112983

Versatile Microfluidic Mixing Platform for High- and Low-Viscosity Liquids via Acoustic and Chemical Microbubbles

Yanfang Guan and Baichuan Sun

Micromachines, 2019, 10, 854
DOI: 10.3390/mi10120854

Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration

Abbas Mokhtari‐Farsani, Masoud Hasany, Iseult Lynch and Mehdi Mehrali

Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202105649

Gold Nanoparticles Contact with Cancer Cell: A Brief Update

Nora Bloise, Silvia Strada, Giacomo Dacarro and Livia Visai

IJMS, 2022, 23, 7683
DOI: 10.3390/ijms23147683

Essential protocols for decoding the composition and the functional effects of the nanoparticle protein corona

Maria Morbidelli, Emanuele Papini and Regina Tavano

Front. Nanotechnol., 2024, 6
DOI: 10.3389/fnano.2024.1500567

Protein corona: Dr. Jekyll and Mr. Hyde of nanomedicine

Elisa Fasoli

Biotechnology and Applied Biochemistry, 2020
DOI: 10.1002/bab.2035

Biomolecular Corona of Gold Nanoparticles: The Urgent Need for Strong Roots to Grow Strong Branches

Luca Boselli, Valentina Castagnola, Andrea Armirotti, Fabio Benfenati and Pier Paolo Pompa

Small, 2024, 20
DOI: 10.1002/smll.202306474

How to effectively prepare a sample for bottom-up proteomic analysis of nanoparticle protein corona? A critical review

Joanna Kruszewska, Joanna Zajda and Magdalena Matczuk

Talanta, 2021, 226, 122153
DOI: 10.1016/j.talanta.2021.122153

Reproducibility of Biomolecular Corona Experiments: A Primer for Reliable Results

Francesca Giulimondi, Erica Quagliarini, Luca Digiacomo, Serena Renzi, Valentina Palmieri, Massimiliano Papi, Daniela Pozzi and Giulio Caracciolo

Part & Part Syst Charact, 2023, 40
DOI: 10.1002/ppsc.202200169

Opto-microfluidic assisted synthesis of photo-protoporphyrin (pPP) conjugated to hollow gold-albumin hybrid nanoshells to enhance the efficiency of photodynamic therapy of triple negative breast cancer cells

Armin Imanparast, Seyed Ali Mousavi Shaegh, Neda Attaran, Amir Reza Ameri and Ameneh Sazgarnia

Photodiagnosis and Photodynamic Therapy, 2023, 43, 103632
DOI: 10.1016/j.pdpdt.2023.103632

Effects of Surface Protein Adsorption on the Distribution and Retention of Intratumorally Administered Gold Nanoparticles

Rossana Terracciano, Aobo Zhang, E. Brian Butler, Danilo Demarchi, Jason H. Hafner, Alessandro Grattoni and Carly S. Filgueira

Pharmaceutics, 2021, 13, 216
DOI: 10.3390/pharmaceutics13020216

The effects of protein corona on in vivo fate of nanocarriers

Qingqing Xiao, Makhloufi Zoulikha, Min Qiu, Chao Teng, Chenshi Lin, Xiaotong Li, Marwa A. Sallam, Qiaobing Xu and Wei He

Advanced Drug Delivery Reviews, 2022, 186, 114356
DOI: 10.1016/j.addr.2022.114356

The Transformative Potential of Lipid Nanoparticle–Protein Corona for Next-Generation Vaccines and Therapeutics

Augusto Amici, Daniela Pozzi, Cristina Marchini and Giulio Caracciolo

Mol. Pharmaceutics, 2023, 20, 5247
DOI: 10.1021/acs.molpharmaceut.3c00479

Efficient pancreatic cancer detection through personalized protein corona of gold nanoparticles

Luca Digiacomo, Damiano Caputo, Roberto Coppola, Chiara Cascone, Francesca Giulimondi, Sara Palchetti, Daniela Pozzi and Giulio Caracciolo

Biointerphases, 2021, 16
DOI: 10.1116/6.0000540