Issue 59, 2022

Nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis

Abstract

Herein, nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis was developed in an undivided cell. This protocol features good functional group tolerance, and is chemical redox agent- and sacrificial electrode-free. Mechanistic studies indicated that the base was crucial for the decarboxylation step and a NiI/NiIII catalytic cycle was involved in this transformation.

Graphical abstract: Nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis

Supplementary files

Article information

Article type
Communication
Submitted
10 máj 2022
Accepted
23 jún 2022
First published
23 jún 2022

Chem. Commun., 2022,58, 8202-8205

Nickel-catalyzed decarboxylative cross-coupling of indole-3-acetic acids with aryl bromides by convergent paired electrolysis

Z. Wang, L. Wei, K. Jiao, C. Ma and T. Mei, Chem. Commun., 2022, 58, 8202 DOI: 10.1039/D2CC02641D

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