Issue 16, 2021

Graphdiyne–hemin-mediated catalytic system for wound disinfection and accelerated wound healing

Abstract

Surgical site infections are the most common and serious concern in health care settings. Currently, systemic administration of prophylactic antibiotics or local disinfection treatment is prescribed after surgical procedures. However, prolonged use of antibiotics may pose adverse side effects, bacterial resistance and hospitalization costs. Recently, the use of nanomaterials with peroxidase enzyme-mimic activity has drawn higher consideration due to their high antibacterial potential and minimum biotoxicity. Hemin is a highly active molecule and also the active source of many biological enzymes, such as peroxidase, which could efficiently catalyze various biochemical reactions. However, the insolubility of hemin makes it easy for it to aggregate and lose its catalytic ability. Here, we designed a well-dispersed hemin/graphdiyne (GDY) nanocomposite (GDY–hemin) with high peroxidase activity. GDY–hemin can decompose hydrogen peroxide (H2O2) to generate highly-toxic hydroxyl radicals that impair bacterial cell membranes, ultimately leading to bacterial death in both in vitro and in vivo experiments. The results reveal that GDY–hemin has good biocompatibility and is suitable for wound infection treatment in vivo.

Graphical abstract: Graphdiyne–hemin-mediated catalytic system for wound disinfection and accelerated wound healing

Supplementary files

Article information

Article type
Research Article
Submitted
28 mar 2021
Accepted
08 jún 2021
First published
09 jún 2021

Mater. Chem. Front., 2021,5, 6041-6051

Graphdiyne–hemin-mediated catalytic system for wound disinfection and accelerated wound healing

A. Ali, J. Liu, H. Zhou, T. Liu, M. Ovais, H. Liu, Y. Rui and C. Chen, Mater. Chem. Front., 2021, 5, 6041 DOI: 10.1039/D1QM00490E

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