Reversible redox-responsive 1H/19F MRI molecular probes

Hongming Chen; Xiaoxue Tang; Xuanqing Gong; Dongxia Chen; Ao Li; Chengjie Sun; Hongyu Lin; Jinhao Gao

doi:10.1039/D0CC00778A

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Reversible redox-responsive ¹H/¹⁹F MRI molecular probes†

Hongming Chen,‡^a Xiaoxue Tang,‡^a Xuanqing Gong,^a Dongxia Chen,^a Ao Li,

^a Chengjie Sun,^a Hongyu Lin*^a and Jinhao Gao

*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
E-mail: hylin007@xmu.edu.cn, jhgao@xmu.edu.cn

^b Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China

Abstract

Herein we report a pair of redox-responsive manganese complexes Mn(III)/(II)-N,N′-bis(2-hydroxy-4-trifluoromethylbenzyl)ethylenediamine-N,N′-diacetate (HTFBED, L1), which are water soluble and biologically interconvertible, as reversible redox-responsive probes in ¹H/¹⁹F MRI for detecting and imaging biological redox species, offering a means to access valuable redox information associated with various diseases.

This article is part of the themed collection: Celebrating a Century of Excellency in Chemistry at Xiamen University

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Article information

DOI: https://doi.org/10.1039/D0CC00778A
Article type: Communication
Submitted: 30 jan 2020
Accepted: 03 mar 2020
First published: 04 mar 2020

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Chem. Commun., 2020,56, 4106-4109

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Reversible redox-responsive ¹H/¹⁹F MRI molecular probes

H. Chen, X. Tang, X. Gong, D. Chen, A. Li, C. Sun, H. Lin and J. Gao, Chem. Commun., 2020, 56, 4106 DOI: 10.1039/D0CC00778A

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Chemical Communications