Issue 41, 2019

Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells

Abstract

The aim of this work was to develop and test the in vitro biological activity of nanocapsules loaded with a doxorubicin (DOX) free base dissolved in a core of castor oil shelled by poly(methyl vinyl ether-co-maleic anhydride) conjugated to n-octadecylamine residues. This system was stable and monodisperse, with a hydrodynamic diameter of about 300 nm. These nanocapsules changed the intracellular distribution of DOX, from the nuclei to the cytoplasm, and exhibited higher toxicity towards cancer cells – 4T1 and MCF-7 – and significantly lower toxicity towards normal cells – NIH-3T3 and MCF-10A – in vitro. In conclusion, these nanocapsules are suitable DOX carriers, which remain to be studied in in vivo tumor models.

Graphical abstract: Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells

Article information

Article type
Paper
Submitted
25 mar 2019
Accepted
02 máj 2019
First published
02 máj 2019

J. Mater. Chem. B, 2019,7, 6390-6398

Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells

J. M. Coelho, N. S. Camargo, R. Ganassin, M. C. O. Rocha, C. Merker, J. Böttner, I. Estrela-Lopis, K. R. Py-Daniel, K. V. Jardim, M. H. Sousa, A. S. Ombredane, G. A. Joanitti, R. C. Silva, R. B. Azevedo, J. P. F. Longo and L. A. Muehlmann, J. Mater. Chem. B, 2019, 7, 6390 DOI: 10.1039/C9TB00587K

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