Issue 15, 2018

Phosphinoyl-functionalization of unactivated alkenes through phosphinoyl radical-triggered distal functional group migration

Abstract

Disclosed herein is a novel and practical protocol for the radical-mediated phosphinoyl-functionalization of unactivated alkenes. The P-centered radicals are generated in the presence of TBHP under mild reaction conditions, which trigger the subsequent distal functional group migration. Both phosphine oxides and phosphonates are suitable precursors for the delivery of phosphinoyl radicals. As a result, phosphinoyl radicals along with another functional group such as heteroaryl, cyano, or imino are incorporated to alkenes concurrently. A wide range of synthetically valuable alkylphosphorus compounds are furnished in good yields.

Graphical abstract: Phosphinoyl-functionalization of unactivated alkenes through phosphinoyl radical-triggered distal functional group migration

Supplementary files

Article information

Article type
Research Article
Submitted
06 jún 2018
Accepted
27 jún 2018
First published
28 jún 2018

Org. Chem. Front., 2018,5, 2370-2374

Phosphinoyl-functionalization of unactivated alkenes through phosphinoyl radical-triggered distal functional group migration

D. Chen, Z. Wu, Y. Yao and C. Zhu, Org. Chem. Front., 2018, 5, 2370 DOI: 10.1039/C8QO00558C

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