Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO2SCF2H or PhSO2SCF3

Bin Xu; Decai Wang; Yonghong Hu; Qilong Shen

doi:10.1039/C8QO00115D

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Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO₂SCF₂H or PhSO₂SCF₃†

Bin Xu,^a Decai Wang,^a Yonghong Hu*^a and Qilong Shen

*^b

Author affiliations

* Corresponding authors

^a Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu Province, P. R. China
E-mail: hyh@njtech.edu.cn

^b Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China
E-mail: shenql@mail.sioc.ac.cn

Abstract

A silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols including cyclopropanols, cyclobutanols, cyclopentanols, cyclohexanols and cycloheptanols was described. A variety of common functional groups such as fluoride, chloride, bromide, iodide, trifluoromethyl, cyano and ester groups were compatible.

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Article information

DOI: https://doi.org/10.1039/C8QO00115D
Article type: Research Article
Submitted: 01 feb 2018
Accepted: 05 mar 2018
First published: 06 mar 2018

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Org. Chem. Front., 2018,5, 1462-1465

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Silver-catalyzed ring-opening difluoromethylthiolation/trifluoromethylthiolation of cycloalkanols with PhSO₂SCF₂H or PhSO₂SCF₃

B. Xu, D. Wang, Y. Hu and Q. Shen, Org. Chem. Front., 2018, 5, 1462 DOI: 10.1039/C8QO00115D

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