Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (−)-curcumol

X. X. Zhang; R. Y. Y. Ko; X. Q. Xie; W. P. Qi; P. C. Li; P. Chiu

doi:10.1039/C7QO01150D

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Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (−)-curcumol†

X. X. Zhang,*^a R. Y. Y. Ko,^b X. Q. Xie,^a W. P. Qi,^a P. C. Li^a and P. Chiu

*^b

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* Corresponding authors

^a College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, P. R. China
E-mail: zhangxx@zjut.edu.cn

^b Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
E-mail: pchiu@hku.hk

Abstract

A de novo asymmetric total synthesis of (−)-curcumol has been realized, based on a rhodium-catalyzed cyclization–cycloaddition cascade reaction as the key step to construct the tricyclic nucleus.

This article is part of the themed collections: Celebrating Excellence in Research: Women at the Frontiers of Chemistry and Synthetic Approaches to Natural Products via Catalytic Processes

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DOI: https://doi.org/10.1039/C7QO01150D
Article type: Research Article
Submitted: 23 dec 2017
Accepted: 23 jan 2018
First published: 23 jan 2018

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Org. Chem. Front., 2018,5, 1092-1095

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Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (−)-curcumol

X. X. Zhang, R. Y. Y. Ko, X. Q. Xie, W. P. Qi, P. C. Li and P. Chiu, Org. Chem. Front., 2018, 5, 1092 DOI: 10.1039/C7QO01150D

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Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (−)-curcumol†

Abstract

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Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (−)-curcumol

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