Issue 11, 2018

Synthetic, small-molecule photoantimicrobials – a realistic approach

Abstract

The search for suitable, low-molecular weight photoantimicrobials for use in infection control has strong foundations in conventional antiseptic research from the early-mid 20th Century. Many examples of dyes exist having conventional antimicrobial activity among the azine, acridine and triphenylmethane families which have since also been found to exhibit photosensitising capabilities. The prior employment of these examples in human antisepsis provides a practical basis in terms of low host toxicity, while extant structure–activity relationships for conventional antimicrobial activity can support the development of similar relationships for photoactivated cell killing. The range of chromophores covered allows progress to be made both in topical and deeper, fluid-involved infections.

Graphical abstract: Synthetic, small-molecule photoantimicrobials – a realistic approach

Article information

Article type
Paper
Submitted
06 apr 2018
Accepted
08 jún 2018
First published
11 jún 2018

Photochem. Photobiol. Sci., 2018,17, 1767-1779

Synthetic, small-molecule photoantimicrobials – a realistic approach

M. Wainwright, Photochem. Photobiol. Sci., 2018, 17, 1767 DOI: 10.1039/C8PP00145F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements