TPZ, a bright centrosymmetric two-photon scaffold for bioimaging

Zuhai Lei; Ping Yue; Xueli Wang; Xinran Li; Yi Li; Haihong He; Xiao Luo; Xiangming Meng; Jinquan Chen; Xuhong Qian; Youjun Yang

doi:10.1039/C7CC06031A

TPZ, a bright centrosymmetric two-photon scaffold for bioimaging†‡

Zuhai Lei,§^a Ping Yue,§^b Xueli Wang,^c Xinran Li,^a Yi Li,^a Haihong He,^a Xiao Luo,^a Xiangming Meng,

*^b Jinquan Chen,

*^c Xuhong Qian^ad and Youjun Yang

*^ad

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* Corresponding authors

^a Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, China
E-mail: youjunyang@ecust.edu.cn, xhqian@ecust.edu.cn

^b Department of Chemistry, Anhui University, Hefei, China
E-mail: mengxm@ahu.edu.cn

^c State Key Laboratory of Precision Spectroscopy, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China
E-mail: jqchen@lps.ecnu.edu.cn

^d State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, China

Abstract

The development of biocompatible two-photon fluorophores with a large absorption cross-section is challenging, despite the presence of theoretical guidelines. By rendering asymmetric PRODAN dye centrosymmetric, we designed and synthesized a novel class of two-photon fluorophores (TPZ). Their photophysical properties were investigated and their imaging potentials in cells, tissues and zebrafish were showcased.

This article is part of the themed collection: Chemosensors and Molecular Logic

Chemical Communications

TPZ, a bright centrosymmetric two-photon scaffold for bioimaging†‡

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TPZ, a bright centrosymmetric two-photon scaffold for bioimaging

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