Issue 4, 2016
From the journal:

Organic Chemistry Frontiers

Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion†

Yuan Pan,a   Gui-Wei Chen,b   Cang-Hai Shen,b   Weimin He*a  and  Long-Wu Ye*bc  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

b State Key Laboratory of Physical Chemistry of Solid Surfaces & The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen 361005, China
E-mail: longwuye@xmu.edu.cn

c State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

A novel gold-catalyzed tandem alkyne amination/intramolecular O–H insertion has been developed. A variety of [1,4]oxazino[3,2-c]isoquinolines are readily accessed under mild reaction conditions by utilizing this strategy, thereby providing an efficient and practical route for the construction of synthetically useful fused isoquinolines.

Graphical abstract: Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

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Article information

DOI
https://doi.org/10.1039/C6QO00033A
Article type
Research Article
Submitted
20 jan 2016
Accepted
12 feb 2016
First published
12 feb 2016

Org. Chem. Front., 2016,3, 491-495

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Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

Y. Pan, G. Chen, C. Shen, W. He and L. Ye, Org. Chem. Front., 2016, 3, 491 DOI: 10.1039/C6QO00033A

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