Issue 5, 2015

Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

Abstract

The initial step of a Pd-catalysed phosphine-free direct arylation reaction was investigated to provide mechanistic insight, leading to optimisation of the catalytic reaction. On the basis of our observations, the amount of the Pd(OAc)2 catalyst was reduced to 1 mol%, affording a good yield of the desired product in combination with a reduction in the amount of by-products.

Graphical abstract: Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

Supplementary files

Article information

Article type
Research Article
Submitted
28 dec 2014
Accepted
10 mar 2015
First published
18 mar 2015

Org. Chem. Front., 2015,2, 520-525

Mechanistic studies and optimisation of a Pd-catalysed direct arylation reaction using phosphine-free systems

J. Kuwabara, M. Sakai, Q. Zhang and T. Kanbara, Org. Chem. Front., 2015, 2, 520 DOI: 10.1039/C4QO00351A

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