Issue 10, 2015

Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

Abstract

Enzyme inhibitory peptides with a loop structure stabilized using an antiparallel β-sheet scaffold (β-loop peptide) were obtained from a designed peptide phage library. Human dihydrofolate reductase (hDHFR) was used as the target enzyme. The obtained β-loop peptides were competitive inhibitors of hDHFR with micromolar inhibition constants and dissociation constants.

Graphical abstract: Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

Supplementary files

Article information

Article type
Communication
Submitted
06 máj 2015
Accepted
17 jún 2015
First published
29 jún 2015

Mol. BioSyst., 2015,11, 2713-2716

Author version available

Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage

H. Tsutsumi, K. Nakano and H. Mihara, Mol. BioSyst., 2015, 11, 2713 DOI: 10.1039/C5MB00316D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements